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Article: Identification of temporal pattern of mandibular condylar growth: a molecular and biochemical experiment.

TitleIdentification of temporal pattern of mandibular condylar growth: a molecular and biochemical experiment.
Authors
Issue Date2005
PublisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=1601-6335&site=1
Citation
Orthodontics & Craniofacial Research, 2005, v. 8 n. 2, p. 114-122 How to Cite?
AbstractOBJECTIVES: Based on the phenomenon that expression of type X collagen and capillary endothelium correlates with endochondral ossification, the prime aim of this study was to establish the temporal pattern of condylar growth in Sprague-Dawley rats by biochemically identifying the expression of these two factors. DESIGN: Sprague-Dawley rats were divided into five groups representing five different stages during somatic pubertal growth. In situ hybridization and immunoperoxidase were performed to examine expression of type X collagen in hypertrophic zone and capillary endothelium in erosive zone of condylar cartilage. Computer-assisted imaging analyses were conducted to allow for a quantitative assessment of the expression of these two factors, from which the temporal pattern of condylar growth was inferred. RESULTS: (1) Synthesis of type X collagen and emergence of capillary endothelium were critical factors during the transition of condylar cartilage from chondrogenesis into osteogenesis, a biological pathway that leads to endochondral bone formation, the mode through which the condyle grows. (2) Quantitative analyses revealed the temporal pattern of the expression of these two factors, indicating that the thrust of natural growth of the condyle in the rats occurred in concomitance with somatic pubertal growth, featured by an acceleration starting from day 38, a maximum growth rate on day 56, followed by a decrease afterwards. CONCLUSION: It is suggested that the biochemical examination of growth markers, such as type X collagen, might be a new approach to accurately depict temporal pattern of condylar growth which is too delicate to be reflected by gross measurement not only in Sprague-Dawley rats but potentially also in other species.
Persistent Identifierhttp://hdl.handle.net/10722/154344
ISSN
2015 Impact Factor: 1.64
2015 SCImago Journal Rankings: 0.881

 

DC FieldValueLanguage
dc.contributor.authorShen, Gen_HK
dc.contributor.authorHägg, Uen_HK
dc.contributor.authorRabie, ABen_HK
dc.contributor.authorKaluarachchi, Ken_HK
dc.date.accessioned2012-08-08T08:24:44Z-
dc.date.available2012-08-08T08:24:44Z-
dc.date.issued2005en_HK
dc.identifier.citationOrthodontics & Craniofacial Research, 2005, v. 8 n. 2, p. 114-122en_HK
dc.identifier.issn1601-6335en_HK
dc.identifier.urihttp://hdl.handle.net/10722/154344-
dc.description.abstractOBJECTIVES: Based on the phenomenon that expression of type X collagen and capillary endothelium correlates with endochondral ossification, the prime aim of this study was to establish the temporal pattern of condylar growth in Sprague-Dawley rats by biochemically identifying the expression of these two factors. DESIGN: Sprague-Dawley rats were divided into five groups representing five different stages during somatic pubertal growth. In situ hybridization and immunoperoxidase were performed to examine expression of type X collagen in hypertrophic zone and capillary endothelium in erosive zone of condylar cartilage. Computer-assisted imaging analyses were conducted to allow for a quantitative assessment of the expression of these two factors, from which the temporal pattern of condylar growth was inferred. RESULTS: (1) Synthesis of type X collagen and emergence of capillary endothelium were critical factors during the transition of condylar cartilage from chondrogenesis into osteogenesis, a biological pathway that leads to endochondral bone formation, the mode through which the condyle grows. (2) Quantitative analyses revealed the temporal pattern of the expression of these two factors, indicating that the thrust of natural growth of the condyle in the rats occurred in concomitance with somatic pubertal growth, featured by an acceleration starting from day 38, a maximum growth rate on day 56, followed by a decrease afterwards. CONCLUSION: It is suggested that the biochemical examination of growth markers, such as type X collagen, might be a new approach to accurately depict temporal pattern of condylar growth which is too delicate to be reflected by gross measurement not only in Sprague-Dawley rats but potentially also in other species.en_HK
dc.languageengen_US
dc.publisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=1601-6335&site=1en_HK
dc.relation.ispartofOrthodontics & craniofacial researchen_HK
dc.subject.meshAnimalsen_US
dc.subject.meshBiochemical Phenomenaen_US
dc.subject.meshBiochemistryen_US
dc.subject.meshCapillaries - Growth & Developmenten_US
dc.subject.meshChondrocytes - Cytologyen_US
dc.subject.meshChondrogenesis - Physiologyen_US
dc.subject.meshCollagen Type X - Analysis - Geneticsen_US
dc.subject.meshEndothelial Cells - Cytologyen_US
dc.subject.meshEndothelium, Vascular - Growth & Developmenten_US
dc.subject.meshFemaleen_US
dc.subject.meshImage Processing, Computer-Assisted - Methodsen_US
dc.subject.meshImmunoenzyme Techniquesen_US
dc.subject.meshIn Situ Hybridizationen_US
dc.subject.meshMandibular Condyle - Blood Supply - Growth & Developmenten_US
dc.subject.meshMolecular Biologyen_US
dc.subject.meshNeovascularization, Physiologic - Physiologyen_US
dc.subject.meshOsteogenesis - Genetics - Physiologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshSexual Maturation - Physiologyen_US
dc.subject.meshTime Factorsen_US
dc.titleIdentification of temporal pattern of mandibular condylar growth: a molecular and biochemical experiment.en_HK
dc.typeArticleen_HK
dc.identifier.emailHägg, U: euohagg@hkusua.hku.hken_HK
dc.identifier.emailRabie, AB: rabie@hku.hken_HK
dc.identifier.authorityHägg, U=rp00020en_HK
dc.identifier.authorityRabie, AB=rp00029en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid15888124-
dc.identifier.scopuseid_2-s2.0-21744441656en_HK
dc.identifier.volume8en_HK
dc.identifier.issue2en_HK
dc.identifier.spage114en_HK
dc.identifier.epage122en_HK
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridShen, G=7401966958en_HK
dc.identifier.scopusauthoridHägg, U=7006790279en_HK
dc.identifier.scopusauthoridRabie, AB=7007172734en_HK
dc.identifier.scopusauthoridKaluarachchi, K=36905056500en_HK

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