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Article: Mechanical strain induces Cbfa1 and type X collagen expression in mandibular condyle

TitleMechanical strain induces Cbfa1 and type X collagen expression in mandibular condyle
Authors
KeywordsCbfa1
Collagen
Mechanical Strain
Type X
Issue Date2005
PublisherFrontiers in Bioscience. The Journal's web site is located at http://www.frontbiosci.org/
Citation
Frontiers In Bioscience, 2005, v. 10 SUPPL. 3, p. 2966-2971 How to Cite?
AbstractCore binding factor a1 (Cbfa1) is a crucial transcriptional factor for chondrocyte maturation and osteoblast differentiation in the mandibular condyle. To quantitatively assess the amount of mRNA expression of Cbfa1 and type X collagen in response to mandibular advancement. 420, 35-day-old female Sprague-Dawley rats, were randomly divided into 20 experimental and 10 control groups corresponding to 10 time points. Experimental animals were advanced in either single or stepwise manner. Condylar cartilage was dissected under microscope and total RNA was extracted, Cbfa1 and type X collagen mRNA was quantified with real-time RT-PCR. Cbfa1 and type X collagen mRNA expression for all groups reached their peak on experimental day 21. During single advancement, Cbfa1 and type X collagen mRNA expression was consistently higher (3-fold and 2.8-fold respectively) than that of stepwise advancement (2-fold). The second advancement in the stepwise group resulted in both Cbfa1 and type X collagen level reaching another peak on day 51. Mandibular advancement promoted chondrocytes maturation and osteoblast differentiation by upregulating Cbfa1 expression. Stepwise advancement produced a higher level of Cbfa1 and type X collagen expression leading to bigger cartilage template onto which bone will form through endochondral ossification.
Persistent Identifierhttp://hdl.handle.net/10722/154335
ISSN
2015 Impact Factor: 2.484
2015 SCImago Journal Rankings: 1.583
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorVan Lam, Sen_HK
dc.contributor.authorRabie, ABMen_HK
dc.date.accessioned2012-08-08T08:24:40Z-
dc.date.available2012-08-08T08:24:40Z-
dc.date.issued2005en_HK
dc.identifier.citationFrontiers In Bioscience, 2005, v. 10 SUPPL. 3, p. 2966-2971en_HK
dc.identifier.issn1093-9946en_HK
dc.identifier.urihttp://hdl.handle.net/10722/154335-
dc.description.abstractCore binding factor a1 (Cbfa1) is a crucial transcriptional factor for chondrocyte maturation and osteoblast differentiation in the mandibular condyle. To quantitatively assess the amount of mRNA expression of Cbfa1 and type X collagen in response to mandibular advancement. 420, 35-day-old female Sprague-Dawley rats, were randomly divided into 20 experimental and 10 control groups corresponding to 10 time points. Experimental animals were advanced in either single or stepwise manner. Condylar cartilage was dissected under microscope and total RNA was extracted, Cbfa1 and type X collagen mRNA was quantified with real-time RT-PCR. Cbfa1 and type X collagen mRNA expression for all groups reached their peak on experimental day 21. During single advancement, Cbfa1 and type X collagen mRNA expression was consistently higher (3-fold and 2.8-fold respectively) than that of stepwise advancement (2-fold). The second advancement in the stepwise group resulted in both Cbfa1 and type X collagen level reaching another peak on day 51. Mandibular advancement promoted chondrocytes maturation and osteoblast differentiation by upregulating Cbfa1 expression. Stepwise advancement produced a higher level of Cbfa1 and type X collagen expression leading to bigger cartilage template onto which bone will form through endochondral ossification.en_HK
dc.languageengen_US
dc.publisherFrontiers in Bioscience. The Journal's web site is located at http://www.frontbiosci.org/en_HK
dc.relation.ispartofFrontiers in Bioscienceen_HK
dc.subjectCbfa1en_HK
dc.subjectCollagenen_HK
dc.subjectMechanical Strainen_HK
dc.subjectType Xen_HK
dc.subject.meshAnimalsen_US
dc.subject.meshCollagen Type X - Genetics - Metabolismen_US
dc.subject.meshCore Binding Factor Alpha 1 Subunit - Genetics - Metabolismen_US
dc.subject.meshFemaleen_US
dc.subject.meshMandibular Condyle - Metabolismen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.titleMechanical strain induces Cbfa1 and type X collagen expression in mandibular condyleen_HK
dc.typeArticleen_HK
dc.identifier.emailRabie, ABM: rabie@hku.hken_HK
dc.identifier.authorityRabie, ABM=rp00029en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid15970550-
dc.identifier.scopuseid_2-s2.0-21344451904en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-21344451904&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume10en_HK
dc.identifier.issueSUPPL. 3en_HK
dc.identifier.spage2966en_HK
dc.identifier.epage2971en_HK
dc.identifier.isiWOS:000232320300079-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridVan Lam, S=8572179300en_HK
dc.identifier.scopusauthoridRabie, ABM=7007172734en_HK

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