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Article: Efficacy of preoperative oral rofecoxib in pain control for third molar surgery

TitleEfficacy of preoperative oral rofecoxib in pain control for third molar surgery
Authors
Issue Date2005
PublisherMosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/tripleo
Citation
Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology And Endodontology, 2005, v. 99 n. 6, p. e47-e53 How to Cite?
AbstractObjective. The study compared the analgesic efficacy of preoperative 50 mg oral rofecoxib, 400 mg ibuprofen, and placebo in the control of postoperative pain after third molar surgery. Study design. This was a clinical randomized, double-blind, cross-over, placebo- and active-comparator-controlled study. The surgeries were randomized into 3 groups, in which patients were given a single dose of 50 mg rofecoxib, 400 mg ibuprofen, or placebo 30-60 minutes before the surgery. The patients were asked to quantify their pain intensity basing on a visual analog scale postoperatively. A rescue medication, 500 mg acetaminophen, was prescribed to the patients. The quantity and time of consumption of the rescue tablets were recorded by the patients. Results. A total of 49 patients completed the study. Of the 98 lower third molar extractions 33 were with rofecoxib, 33 ibuprofen, and 32 placebo. The pain scores within the first 6 hours postoperatively in the rofecoxib group were significantly lower than the placebo (P <. 05). The ibuprofen group did not have significantly lower pain scores than the placebo group. Regarding the postoperative requirement of rescue medication, the rofecoxib group required significantly less rescue medication than both ibuprofen and placebo groups in the first twelve hours after the surgery. Conclusions. The preoperative oral intake of 50 mg rofecoxib provides a significantly better analgesic benefit than the placebo for postoperative pain relief in the first 6 hours after third molar surgery. This regimen also reduced the requirement of postoperative analgesic when compared with ibuprofen and placebo in the first 12 postoperative hours. © 2005 Mosby, Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/154331
ISSN
2011 Impact Factor: 1.457
References

 

DC FieldValueLanguage
dc.contributor.authorChiu, WKen_US
dc.contributor.authorCheung, LKen_US
dc.date.accessioned2012-08-08T08:24:39Z-
dc.date.available2012-08-08T08:24:39Z-
dc.date.issued2005en_US
dc.identifier.citationOral Surgery, Oral Medicine, Oral Pathology, Oral Radiology And Endodontology, 2005, v. 99 n. 6, p. e47-e53en_US
dc.identifier.issn1079-2104en_US
dc.identifier.urihttp://hdl.handle.net/10722/154331-
dc.description.abstractObjective. The study compared the analgesic efficacy of preoperative 50 mg oral rofecoxib, 400 mg ibuprofen, and placebo in the control of postoperative pain after third molar surgery. Study design. This was a clinical randomized, double-blind, cross-over, placebo- and active-comparator-controlled study. The surgeries were randomized into 3 groups, in which patients were given a single dose of 50 mg rofecoxib, 400 mg ibuprofen, or placebo 30-60 minutes before the surgery. The patients were asked to quantify their pain intensity basing on a visual analog scale postoperatively. A rescue medication, 500 mg acetaminophen, was prescribed to the patients. The quantity and time of consumption of the rescue tablets were recorded by the patients. Results. A total of 49 patients completed the study. Of the 98 lower third molar extractions 33 were with rofecoxib, 33 ibuprofen, and 32 placebo. The pain scores within the first 6 hours postoperatively in the rofecoxib group were significantly lower than the placebo (P <. 05). The ibuprofen group did not have significantly lower pain scores than the placebo group. Regarding the postoperative requirement of rescue medication, the rofecoxib group required significantly less rescue medication than both ibuprofen and placebo groups in the first twelve hours after the surgery. Conclusions. The preoperative oral intake of 50 mg rofecoxib provides a significantly better analgesic benefit than the placebo for postoperative pain relief in the first 6 hours after third molar surgery. This regimen also reduced the requirement of postoperative analgesic when compared with ibuprofen and placebo in the first 12 postoperative hours. © 2005 Mosby, Inc. All rights reserved.en_US
dc.languageengen_US
dc.publisherMosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/tripleoen_US
dc.relation.ispartofOral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontologyen_US
dc.rightsOral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology. Copyright © Mosby, Inc.-
dc.subject.meshAdministration, Oralen_US
dc.subject.meshAdulten_US
dc.subject.meshAnalysis Of Varianceen_US
dc.subject.meshAnti-Inflammatory Agents, Non-Steroidal - Administration & Dosageen_US
dc.subject.meshCross-Over Studiesen_US
dc.subject.meshCyclooxygenase 2 Inhibitors - Administration & Dosageen_US
dc.subject.meshDouble-Blind Methoden_US
dc.subject.meshFacial Pain - Prevention & Controlen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshIbuprofen - Administration & Dosageen_US
dc.subject.meshLactones - Administration & Dosageen_US
dc.subject.meshMaleen_US
dc.subject.meshMolar, Third - Surgeryen_US
dc.subject.meshPain Measurementen_US
dc.subject.meshPain, Postoperative - Prevention & Controlen_US
dc.subject.meshPreoperative Careen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshStatistics, Nonparametricen_US
dc.subject.meshSulfones - Administration & Dosageen_US
dc.subject.meshTooth Extractionen_US
dc.titleEfficacy of preoperative oral rofecoxib in pain control for third molar surgeryen_US
dc.typeArticleen_US
dc.identifier.emailCheung, LK:lkcheung@hkucc.hku.hken_US
dc.identifier.authorityCheung, LK=rp00013en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.tripleo.2005.02.075en_US
dc.identifier.pmid15897845-
dc.identifier.scopuseid_2-s2.0-19344363993en_US
dc.identifier.hkuros100409-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-19344363993&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume99en_US
dc.identifier.issue6en_US
dc.identifier.spagee47en_US
dc.identifier.epagee53en_US
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridChiu, WK=36177164400en_US
dc.identifier.scopusauthoridCheung, LK=7102302747en_US

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