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Article: Enamel matrix proteins in the regenerative therapy of deep intrabony defects: A multicentre randomized controlled clinical trial

TitleEnamel matrix proteins in the regenerative therapy of deep intrabony defects: A multicentre randomized controlled clinical trial
Authors
KeywordsDifferentiation Factors
Intrabony Defects
Periodontal Regeneration
Periodontal Surgery
Randomized Controlled Clinical Trial
Issue Date2002
PublisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CPE
Citation
Journal Of Clinical Periodontology, 2002, v. 29 n. 4, p. 317-325 How to Cite?
AbstractAim: This prospective multicentre randomized controlled clinical trial was designed to compare the clinical outcomes of papilla preservation flap surgery with or without the application of enamel matrix proteins (EMD). Material and methods: 172 patients with advanced chronic periodontitis were recruited in 12 centers in 7 countries. All patients had at least one intrabony defect of ≥3mm. Heavy smokers (≥20 cigarettes/day) were excluded. The surgical procedures included access for root instrumentation using either the simplified or the modified papilla preservation flap in order to obtain optimal tissue adaptation and primary closure. After debridement, roots were conditioned for 2 min with a gel containing 24% EDTA. EMD was applied in the test subjects, and omitted in the controls. Postsurgically, a strict plaque control protocol was followed. At baseline and 1 year following the interventions, clinical attachment levels (CAL), pocket probing depths (PPD), recession (REC), full-mouth plaque scores and full-mouth bleeding scores were assessed. A total of 166 patients were available for the 1-year follow-up. Results: At baseline, 86 test and 86 control patients presented with similar subject and defect characteristics. On average, the test defects gained 3.1 ± 1.5 mm of CAL, while the control defects yielded a significantly lower CAL gain of 2.5 ± 1.5 mm. Pocket reduction was also significantly higher in the test group (3.9 ± 1.7 mm) when compared to the controls (3.3 ± 1.7 mm). A multivariate analysis indicated that the treatment, the clinical centers, cigarette smoking, baseline PPD, and defect corticalisation significantly influenced CAL gains. A frequency distribution analysis of the studied outcomes indicated that EMD increased the predictability of clinically significant results (CAL gains ≥4 mm) and decreased the probability of obtaining negligible or no gains in CAL (CAL gains <2 mm). Conclusions: The results of this trial indicated that regenerative periodontal surgery with EMD offers an additional benefit in terms of CAL gains, PPD reductions and predictability of outcomes with respect to papilla preservation flaps alone. © Blackwell Munksgaard, 2002.
Persistent Identifierhttp://hdl.handle.net/10722/154312
ISSN
2015 Impact Factor: 3.915
2015 SCImago Journal Rankings: 1.848
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTonetti, MSen_US
dc.contributor.authorLang, NPen_US
dc.contributor.authorCortellini, Pen_US
dc.contributor.authorSuvan, JEen_US
dc.contributor.authorAdriaens, Pen_US
dc.contributor.authorDubravec, Den_US
dc.contributor.authorFonzar, Aen_US
dc.contributor.authorFourmousis, Ien_US
dc.contributor.authorMayfield, Len_US
dc.contributor.authorRossi, Ren_US
dc.contributor.authorSilvestri, Men_US
dc.contributor.authorTiedemann, Cen_US
dc.contributor.authorTopoll, Hen_US
dc.contributor.authorVangsted, Ten_US
dc.contributor.authorWallkamm, Ben_US
dc.date.accessioned2012-08-08T08:24:33Z-
dc.date.available2012-08-08T08:24:33Z-
dc.date.issued2002en_US
dc.identifier.citationJournal Of Clinical Periodontology, 2002, v. 29 n. 4, p. 317-325en_US
dc.identifier.issn0303-6979en_US
dc.identifier.urihttp://hdl.handle.net/10722/154312-
dc.description.abstractAim: This prospective multicentre randomized controlled clinical trial was designed to compare the clinical outcomes of papilla preservation flap surgery with or without the application of enamel matrix proteins (EMD). Material and methods: 172 patients with advanced chronic periodontitis were recruited in 12 centers in 7 countries. All patients had at least one intrabony defect of ≥3mm. Heavy smokers (≥20 cigarettes/day) were excluded. The surgical procedures included access for root instrumentation using either the simplified or the modified papilla preservation flap in order to obtain optimal tissue adaptation and primary closure. After debridement, roots were conditioned for 2 min with a gel containing 24% EDTA. EMD was applied in the test subjects, and omitted in the controls. Postsurgically, a strict plaque control protocol was followed. At baseline and 1 year following the interventions, clinical attachment levels (CAL), pocket probing depths (PPD), recession (REC), full-mouth plaque scores and full-mouth bleeding scores were assessed. A total of 166 patients were available for the 1-year follow-up. Results: At baseline, 86 test and 86 control patients presented with similar subject and defect characteristics. On average, the test defects gained 3.1 ± 1.5 mm of CAL, while the control defects yielded a significantly lower CAL gain of 2.5 ± 1.5 mm. Pocket reduction was also significantly higher in the test group (3.9 ± 1.7 mm) when compared to the controls (3.3 ± 1.7 mm). A multivariate analysis indicated that the treatment, the clinical centers, cigarette smoking, baseline PPD, and defect corticalisation significantly influenced CAL gains. A frequency distribution analysis of the studied outcomes indicated that EMD increased the predictability of clinically significant results (CAL gains ≥4 mm) and decreased the probability of obtaining negligible or no gains in CAL (CAL gains <2 mm). Conclusions: The results of this trial indicated that regenerative periodontal surgery with EMD offers an additional benefit in terms of CAL gains, PPD reductions and predictability of outcomes with respect to papilla preservation flaps alone. © Blackwell Munksgaard, 2002.en_US
dc.languageengen_US
dc.publisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CPEen_US
dc.relation.ispartofJournal of Clinical Periodontologyen_US
dc.subjectDifferentiation Factorsen_US
dc.subjectIntrabony Defectsen_US
dc.subjectPeriodontal Regenerationen_US
dc.subjectPeriodontal Surgeryen_US
dc.subjectRandomized Controlled Clinical Trialen_US
dc.titleEnamel matrix proteins in the regenerative therapy of deep intrabony defects: A multicentre randomized controlled clinical trialen_US
dc.typeArticleen_US
dc.identifier.emailLang, NP:nplang@hkucc.hku.hken_US
dc.identifier.authorityLang, NP=rp00031en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1034/j.1600-051X.2002.290407.xen_US
dc.identifier.pmid11966929-
dc.identifier.scopuseid_2-s2.0-17444441197en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-17444441197&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume29en_US
dc.identifier.issue4en_US
dc.identifier.spage317en_US
dc.identifier.epage325en_US
dc.identifier.isiWOS:000174670900007-
dc.publisher.placeDenmarken_US
dc.identifier.scopusauthoridTonetti, MS=35602248900en_US
dc.identifier.scopusauthoridLang, NP=7201577367en_US
dc.identifier.scopusauthoridCortellini, P=7004422576en_US
dc.identifier.scopusauthoridSuvan, JE=19637686000en_US
dc.identifier.scopusauthoridAdriaens, P=7007006026en_US
dc.identifier.scopusauthoridDubravec, D=36963026500en_US
dc.identifier.scopusauthoridFonzar, A=6506961336en_US
dc.identifier.scopusauthoridFourmousis, I=6602718088en_US
dc.identifier.scopusauthoridMayfield, L=7004160753en_US
dc.identifier.scopusauthoridRossi, R=8061093400en_US
dc.identifier.scopusauthoridSilvestri, M=7006617344en_US
dc.identifier.scopusauthoridTiedemann, C=6603143268en_US
dc.identifier.scopusauthoridTopoll, H=7004437263en_US
dc.identifier.scopusauthoridVangsted, T=6508378968en_US
dc.identifier.scopusauthoridWallkamm, B=6603265034en_US

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