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Article: The junctional epithelium: From health to disease

TitleThe junctional epithelium: From health to disease
Authors
Issue Date2005
PublisherSage Publications, Inc.. The Journal's web site is located at http://www.sagepub.com/journalsProdDesc.nav?prodId=Journal201925
Citation
Journal Of Dental Research, 2005, v. 84 n. 1, p. 9-20 How to Cite?
AbstractThe junctional epithelium is located at a strategically important interface between the gingival sulcus, populated with bacteria, and the periodontal soft and mineralized connective tissues that need protection from becoming exposed to bacteria and their products. Its unique structural and functional adaptation enables the junctional epithelium to control the constant microbiological challenge. The antimicrobial defense mechanisms of the junctional epithelium, however, do not preclude the development of gingival and periodontal lesions. The conversion of the junctional to pocket epithelium, which is regarded as a hallmark in disease initiation, has been the focus of intense research in recent years. Research has shown that the junctional epithelial cells may play a much more active role in the innate defense mechanisms than previously assumed. They synthesize a variety of molecules directly involved in the combat against bacteria and their products. In addition, they express molecules that mediate the migration of polymorphonuclear leukocytes toward the bottom of the gingival sulcus. Periodontopathogens-such as Actinobacillus actinomycetemcomitans or, in particular, Porphyromonas gingivalis-have developed sophisticated methods to perturb the structural and functional integrity of the junctional epithelium. Research has focused on the direct effects of gingipains, cysteine proteinases produced by Porphyromonas gingivalis, on junctional epithelial cells. These virulence factors may specifically degrade components of the cell-to-cell contacts. This review will focus on the unique structural organization of the junctional epithelium, on the nature and functions of the various molecules expressed by its cells, and on how gingipains may attenuate the junctional epithelium's structural and functional integrity.
Persistent Identifierhttp://hdl.handle.net/10722/154309
ISSN
2015 Impact Factor: 4.602
2015 SCImago Journal Rankings: 1.714
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorBosshardt, DDen_US
dc.contributor.authorLang, NPen_US
dc.date.accessioned2012-08-08T08:24:32Z-
dc.date.available2012-08-08T08:24:32Z-
dc.date.issued2005en_US
dc.identifier.citationJournal Of Dental Research, 2005, v. 84 n. 1, p. 9-20en_US
dc.identifier.issn0022-0345en_US
dc.identifier.urihttp://hdl.handle.net/10722/154309-
dc.description.abstractThe junctional epithelium is located at a strategically important interface between the gingival sulcus, populated with bacteria, and the periodontal soft and mineralized connective tissues that need protection from becoming exposed to bacteria and their products. Its unique structural and functional adaptation enables the junctional epithelium to control the constant microbiological challenge. The antimicrobial defense mechanisms of the junctional epithelium, however, do not preclude the development of gingival and periodontal lesions. The conversion of the junctional to pocket epithelium, which is regarded as a hallmark in disease initiation, has been the focus of intense research in recent years. Research has shown that the junctional epithelial cells may play a much more active role in the innate defense mechanisms than previously assumed. They synthesize a variety of molecules directly involved in the combat against bacteria and their products. In addition, they express molecules that mediate the migration of polymorphonuclear leukocytes toward the bottom of the gingival sulcus. Periodontopathogens-such as Actinobacillus actinomycetemcomitans or, in particular, Porphyromonas gingivalis-have developed sophisticated methods to perturb the structural and functional integrity of the junctional epithelium. Research has focused on the direct effects of gingipains, cysteine proteinases produced by Porphyromonas gingivalis, on junctional epithelial cells. These virulence factors may specifically degrade components of the cell-to-cell contacts. This review will focus on the unique structural organization of the junctional epithelium, on the nature and functions of the various molecules expressed by its cells, and on how gingipains may attenuate the junctional epithelium's structural and functional integrity.en_US
dc.languageengen_US
dc.publisherSage Publications, Inc.. The Journal's web site is located at http://www.sagepub.com/journalsProdDesc.nav?prodId=Journal201925en_US
dc.relation.ispartofJournal of Dental Researchen_US
dc.subject.meshAdhesins, Bacterial - Biosynthesisen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCell Adhesion Molecules - Biosynthesisen_US
dc.subject.meshCell Communicationen_US
dc.subject.meshCysteine Endopeptidases - Biosynthesisen_US
dc.subject.meshCytokines - Biosynthesisen_US
dc.subject.meshEpithelial Attachment - Anatomy & Histology - Metabolism - Microbiologyen_US
dc.subject.meshHemagglutinins - Biosynthesisen_US
dc.subject.meshHumansen_US
dc.subject.meshPeriodontal Pocket - Microbiologyen_US
dc.subject.meshPorphyromonas Gingivalis - Metabolism - Pathogenicityen_US
dc.titleThe junctional epithelium: From health to diseaseen_US
dc.typeArticleen_US
dc.identifier.emailLang, NP:nplang@hkucc.hku.hken_US
dc.identifier.authorityLang, NP=rp00031en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1177/154405910508400102en_US
dc.identifier.pmid15615869-
dc.identifier.scopuseid_2-s2.0-16644396846en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-16644396846&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume84en_US
dc.identifier.issue1en_US
dc.identifier.spage9en_US
dc.identifier.epage20en_US
dc.identifier.isiWOS:000226834000002-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridBosshardt, DD=6603806230en_US
dc.identifier.scopusauthoridLang, NP=7201577367en_US

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