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Article: Vascular endothelial growth factor expression and bone formation in posterior glenoid fossa during stepwise mandibular advancement

TitleVascular endothelial growth factor expression and bone formation in posterior glenoid fossa during stepwise mandibular advancement
Authors
Issue Date2004
PublisherMosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/ajodo
Citation
American Journal Of Orthodontics And Dentofacial Orthopedics, 2004, v. 125 n. 2, p. 185-190 How to Cite?
AbstractThis study assessed the amount of vascular endothelial growth factor (VEGF) expression and related the findings to new bone formation in the posterior glenoid fossa during stepwise mandibular advancement. A total of 250 female Sprague-Dawley rats, 35 days old, were randomly divided into 10 groups, each including 5 control and 20 experimental rats. Within each group, 10 experimental rats were fitted with functional appliances with a 1-step advancement of 3.5 mm. Another 10 were fitted with stepwise appliances with an initial advancement of 2 mm and a subsequent increase to 3.5 mm on day 30. The rats in the experimental groups were killed on days 3, 7, 14, 21, 30, 33, 37, 44, 51, and 60, respectively. The matched controls were killed on the same time points. Sections (7 μm) were cut through the glenoid fossa sagittally and stained with anti-VEGF antibody. VEGF expression in the posterior glenoid fossa was evaluated with a computer-assisted image-analyzing system. Both VEGF expression and new bone formation were greater in the experimental rats than in the controls. During stepwise advancement, initial VEGF expression was less than that of 1-step advancement, but the second advancement elicited another peak on day 44. New bone formation was also less than that of 1-step advancement during early stages of stepwise advancement but then began to increase from day 37 onward. The maximum increase was observed on day 60. Stepwise advancement of the mandible delivers mechanical stimuli that produce a series of tissue responses that lead to increased vascularization and bone formation.
Persistent Identifierhttp://hdl.handle.net/10722/154281
ISSN
2015 Impact Factor: 1.69
2015 SCImago Journal Rankings: 1.249
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorShum, Len_HK
dc.contributor.authorRabie, ABMen_HK
dc.contributor.authorHägg, Uen_HK
dc.date.accessioned2012-08-08T08:24:22Z-
dc.date.available2012-08-08T08:24:22Z-
dc.date.issued2004en_HK
dc.identifier.citationAmerican Journal Of Orthodontics And Dentofacial Orthopedics, 2004, v. 125 n. 2, p. 185-190en_HK
dc.identifier.issn0889-5406en_HK
dc.identifier.urihttp://hdl.handle.net/10722/154281-
dc.description.abstractThis study assessed the amount of vascular endothelial growth factor (VEGF) expression and related the findings to new bone formation in the posterior glenoid fossa during stepwise mandibular advancement. A total of 250 female Sprague-Dawley rats, 35 days old, were randomly divided into 10 groups, each including 5 control and 20 experimental rats. Within each group, 10 experimental rats were fitted with functional appliances with a 1-step advancement of 3.5 mm. Another 10 were fitted with stepwise appliances with an initial advancement of 2 mm and a subsequent increase to 3.5 mm on day 30. The rats in the experimental groups were killed on days 3, 7, 14, 21, 30, 33, 37, 44, 51, and 60, respectively. The matched controls were killed on the same time points. Sections (7 μm) were cut through the glenoid fossa sagittally and stained with anti-VEGF antibody. VEGF expression in the posterior glenoid fossa was evaluated with a computer-assisted image-analyzing system. Both VEGF expression and new bone formation were greater in the experimental rats than in the controls. During stepwise advancement, initial VEGF expression was less than that of 1-step advancement, but the second advancement elicited another peak on day 44. New bone formation was also less than that of 1-step advancement during early stages of stepwise advancement but then began to increase from day 37 onward. The maximum increase was observed on day 60. Stepwise advancement of the mandible delivers mechanical stimuli that produce a series of tissue responses that lead to increased vascularization and bone formation.en_HK
dc.languageengen_US
dc.publisherMosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/ajodoen_HK
dc.relation.ispartofAmerican Journal of Orthodontics and Dentofacial Orthopedicsen_HK
dc.rightsAmerican Journal of Orthodontics and Dentofacial Orthopedics. Copyright © Mosby, Inc.-
dc.subject.meshAnalysis Of Varianceen_US
dc.subject.meshAnimalsen_US
dc.subject.meshColoring Agents - Diagnostic Useen_US
dc.subject.meshFemaleen_US
dc.subject.meshImage Processing, Computer-Assisteden_US
dc.subject.meshMandibular Advancement - Instrumentation - Methodsen_US
dc.subject.meshOrthodontic Appliances, Functionalen_US
dc.subject.meshOsteogenesis - Physiologyen_US
dc.subject.meshRandom Allocationen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshStress, Mechanicalen_US
dc.subject.meshTemporal Bone - Pathology - Physiopathologyen_US
dc.subject.meshTime Factorsen_US
dc.subject.meshVascular Endothelial Growth Factor A - Analysisen_US
dc.titleVascular endothelial growth factor expression and bone formation in posterior glenoid fossa during stepwise mandibular advancementen_HK
dc.typeArticleen_HK
dc.identifier.emailRabie, ABM: rabie@hku.hken_HK
dc.identifier.emailHägg, U: euohagg@hkusua.hku.hken_HK
dc.identifier.authorityRabie, ABM=rp00029en_HK
dc.identifier.authorityHägg, U=rp00020en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.ajodo.2002.12.002en_HK
dc.identifier.pmid14765056-
dc.identifier.scopuseid_2-s2.0-1042289403en_HK
dc.identifier.hkuros95054-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-1042289403&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume125en_HK
dc.identifier.issue2en_HK
dc.identifier.spage185en_HK
dc.identifier.epage190en_HK
dc.identifier.isiWOS:000188968700012-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridShum, L=7003895312en_HK
dc.identifier.scopusauthoridRabie, ABM=7007172734en_HK
dc.identifier.scopusauthoridHägg, U=7006790279en_HK

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