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Article: Effect of bioresorbable fibres (Polyfibre®) and a bioresorbable foam (Polyfoam®) on new bone formation: A short term experimental study on the rabbit skull

TitleEffect of bioresorbable fibres (Polyfibre®) and a bioresorbable foam (Polyfoam®) on new bone formation: A short term experimental study on the rabbit skull
Authors
Issue Date2003
PublisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CLR
Citation
Clinical Oral Implants Research, 2003, v. 14 n. 6, p. 734-742 How to Cite?
AbstractThe aim of the study was to evaluate two bioresorbable polylactic acid (PLA) filler materials in a guided bone regeneration (GBR) model system. The first was Polyfibre®, a fibrous PLA filler material. Polyfoam®, the second material tested, consisted of a spongy PLA filler material. In each group there were eight rabbits. In test rabbits a flap was raised uncovering the calvaria. A hemispherical PLA dome was filled with Polyfibre® or Polyfoam® material and periphereal blood and anchored onto the calvaria. Eight rabbits with the same domes, filled with blood alone, served as controls. The rabbits were sacrificed at 1 or 2 months. Histomorphometric measurements of regenerated total tissue volume, bone height and bone volume were carried out in undecalcified sections under a light microscope. At 1 month the totally filled volume attained 87% (range 82-91) in the fibre group, including 25% (23-27) fibres, 87% (85-95) in the foam group, including 15% (15-16) foam, and 55% (16-100) in the controls. The volume of mineralized bone was 12% (7-15) in the fibre group, 15% (12-18) in the foam group and 6% (1-11) in control domes. Bone height attained 48% (27-79) in the fibre group, 37% (31-58) in the foam group and 45% (14-67) in the control group. At 2 months, tissue volume attained 86% (85-87) including 26% (22-29) fibres, bone volume attained 13% (7-21) and bone height attained 56% (42-78) in the Polyfibre® group. In the Polyfoam® group, they were 83% (55-99) including 18% (15-19) foam, 13% (7-24) and 49% (29-74). In control domes, tissue volume was 82% (35-100), bone volume 20% (9-27) and bone height 86% (60-100). The Polyfibre® and Polyfoam® material was excellently integrated. No adverse reactions were found in the surrounding tissues. Direct bone apposition was observed onto the material. In conclusion, Polyfibre® and Polyfoam® material had a positive effect on initial bone and tissue formation but was a hindrance to increasing tissue volume, bone volume or bone height at 2 months compared to control specimens. The Polyfibre® and Polyfoam® material provoked no adverse reactions in the surrounding tissues and allowed for extensive angiogenesis.
Persistent Identifierhttp://hdl.handle.net/10722/154273
ISSN
2015 Impact Factor: 3.464
2015 SCImago Journal Rankings: 1.427
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWallkamm, Ben_US
dc.contributor.authorSchmid, Jen_US
dc.contributor.authorHämmerle, CHFen_US
dc.contributor.authorGogolewski, Sen_US
dc.contributor.authorLang, NPen_US
dc.date.accessioned2012-08-08T08:24:20Z-
dc.date.available2012-08-08T08:24:20Z-
dc.date.issued2003en_US
dc.identifier.citationClinical Oral Implants Research, 2003, v. 14 n. 6, p. 734-742en_US
dc.identifier.issn0905-7161en_US
dc.identifier.urihttp://hdl.handle.net/10722/154273-
dc.description.abstractThe aim of the study was to evaluate two bioresorbable polylactic acid (PLA) filler materials in a guided bone regeneration (GBR) model system. The first was Polyfibre®, a fibrous PLA filler material. Polyfoam®, the second material tested, consisted of a spongy PLA filler material. In each group there were eight rabbits. In test rabbits a flap was raised uncovering the calvaria. A hemispherical PLA dome was filled with Polyfibre® or Polyfoam® material and periphereal blood and anchored onto the calvaria. Eight rabbits with the same domes, filled with blood alone, served as controls. The rabbits were sacrificed at 1 or 2 months. Histomorphometric measurements of regenerated total tissue volume, bone height and bone volume were carried out in undecalcified sections under a light microscope. At 1 month the totally filled volume attained 87% (range 82-91) in the fibre group, including 25% (23-27) fibres, 87% (85-95) in the foam group, including 15% (15-16) foam, and 55% (16-100) in the controls. The volume of mineralized bone was 12% (7-15) in the fibre group, 15% (12-18) in the foam group and 6% (1-11) in control domes. Bone height attained 48% (27-79) in the fibre group, 37% (31-58) in the foam group and 45% (14-67) in the control group. At 2 months, tissue volume attained 86% (85-87) including 26% (22-29) fibres, bone volume attained 13% (7-21) and bone height attained 56% (42-78) in the Polyfibre® group. In the Polyfoam® group, they were 83% (55-99) including 18% (15-19) foam, 13% (7-24) and 49% (29-74). In control domes, tissue volume was 82% (35-100), bone volume 20% (9-27) and bone height 86% (60-100). The Polyfibre® and Polyfoam® material was excellently integrated. No adverse reactions were found in the surrounding tissues. Direct bone apposition was observed onto the material. In conclusion, Polyfibre® and Polyfoam® material had a positive effect on initial bone and tissue formation but was a hindrance to increasing tissue volume, bone volume or bone height at 2 months compared to control specimens. The Polyfibre® and Polyfoam® material provoked no adverse reactions in the surrounding tissues and allowed for extensive angiogenesis.en_US
dc.languageengen_US
dc.publisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CLRen_US
dc.relation.ispartofClinical Oral Implants Researchen_US
dc.subject.meshAbsorbable Implantsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBiocompatible Materials - Pharmacologyen_US
dc.subject.meshBone Regeneration - Drug Effects - Physiologyen_US
dc.subject.meshBone Substitutes - Pharmacologyen_US
dc.subject.meshLactic Acid - Pharmacologyen_US
dc.subject.meshOsteogenesis - Drug Effects - Physiologyen_US
dc.subject.meshPolymers - Pharmacologyen_US
dc.subject.meshRabbitsen_US
dc.subject.meshSkull - Cytology - Drug Effects - Surgeryen_US
dc.titleEffect of bioresorbable fibres (Polyfibre®) and a bioresorbable foam (Polyfoam®) on new bone formation: A short term experimental study on the rabbit skullen_US
dc.typeArticleen_US
dc.identifier.emailLang, NP:nplang@hkucc.hku.hken_US
dc.identifier.authorityLang, NP=rp00031en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1046/j.0905-7161.2003.00930.xen_US
dc.identifier.pmid15015950-
dc.identifier.scopuseid_2-s2.0-0348111312en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0348111312&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume14en_US
dc.identifier.issue6en_US
dc.identifier.spage734en_US
dc.identifier.epage742en_US
dc.identifier.isiWOS:000187107700010-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridWallkamm, B=6603265034en_US
dc.identifier.scopusauthoridSchmid, J=8419181200en_US
dc.identifier.scopusauthoridHämmerle, CHF=7005331848en_US
dc.identifier.scopusauthoridGogolewski, S=7004684875en_US
dc.identifier.scopusauthoridLang, NP=7201577367en_US

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