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Article: Healing of Maxillary Alveolus in Transport Distraction Osteogenesis for Partial Maxillectomy

TitleHealing of Maxillary Alveolus in Transport Distraction Osteogenesis for Partial Maxillectomy
Authors
Issue Date2004
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/joms
Citation
Journal Of Oral And Maxillofacial Surgery, 2004, v. 62 n. 1, p. 66-72 How to Cite?
AbstractPurpose: This study aims to evaluate histologic healing of the new bone and soft tissue in the distraction gap of maxillary alveolus after transport distraction at different consolidation intervals. Materials and Methods: In a monkey model, dentoalveolar segment was distracted backward to a surgical defect in the posterior maxilla with an internal distractor at a rate of 1 mm/day for 2 weeks. The distracted dentoalveolar processes were harvested at 1, 2, and 3 months of consolidation after the completion of distraction. Histologic examination included the new bone, gingiva of the distraction gap, and teeth carrying the transport segments. Tartrate-resistant acid phosphatase was used to assess the presence of osteoclasts in the new bone. The collagen type and expression of bone morphogenetic proteins (BMPs) in the new bone were assessed by immunohistochemistry. Results: The histology confirmed new bone bridging the distraction gap at 1 month of consolidation. Woven bone was progressively replaced by mature lamellar bone at the second and third months. The gingiva covering the distraction gap was of normal appearance. There were no pathologic pulpal changes noted in the transport segment. Tartrate-resistant acid phosphatase-positive osteoclasts were minimal in the new bone. The mode of ossification was confirmed as intramembranous, and the fibrous stroma consisted mainly of collagen type I. At 1 month of consolidation, the BMPs were expressed profusely in the fibrous matrix and also inside the fibroblasts and osteoblasts. At 2 and 3 months of consolidation, the BMP expression intensity was reduced significantly in the fibrous stroma. Conclusions: The study confirmed that the bone regenerate in maxillary transport distraction was formed by intramembranous ossification and teeth in the transport segment remain viable after maxillary transport distraction osteogenesis. © 2004 American Association of Oral and Maxillofacial Surgeons.
Persistent Identifierhttp://hdl.handle.net/10722/154268
ISSN
2015 Impact Factor: 1.631
2015 SCImago Journal Rankings: 0.824
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, LKen_US
dc.contributor.authorZhang, Qen_US
dc.date.accessioned2012-08-08T08:24:19Z-
dc.date.available2012-08-08T08:24:19Z-
dc.date.issued2004en_US
dc.identifier.citationJournal Of Oral And Maxillofacial Surgery, 2004, v. 62 n. 1, p. 66-72en_US
dc.identifier.issn0278-2391en_US
dc.identifier.urihttp://hdl.handle.net/10722/154268-
dc.description.abstractPurpose: This study aims to evaluate histologic healing of the new bone and soft tissue in the distraction gap of maxillary alveolus after transport distraction at different consolidation intervals. Materials and Methods: In a monkey model, dentoalveolar segment was distracted backward to a surgical defect in the posterior maxilla with an internal distractor at a rate of 1 mm/day for 2 weeks. The distracted dentoalveolar processes were harvested at 1, 2, and 3 months of consolidation after the completion of distraction. Histologic examination included the new bone, gingiva of the distraction gap, and teeth carrying the transport segments. Tartrate-resistant acid phosphatase was used to assess the presence of osteoclasts in the new bone. The collagen type and expression of bone morphogenetic proteins (BMPs) in the new bone were assessed by immunohistochemistry. Results: The histology confirmed new bone bridging the distraction gap at 1 month of consolidation. Woven bone was progressively replaced by mature lamellar bone at the second and third months. The gingiva covering the distraction gap was of normal appearance. There were no pathologic pulpal changes noted in the transport segment. Tartrate-resistant acid phosphatase-positive osteoclasts were minimal in the new bone. The mode of ossification was confirmed as intramembranous, and the fibrous stroma consisted mainly of collagen type I. At 1 month of consolidation, the BMPs were expressed profusely in the fibrous matrix and also inside the fibroblasts and osteoblasts. At 2 and 3 months of consolidation, the BMP expression intensity was reduced significantly in the fibrous stroma. Conclusions: The study confirmed that the bone regenerate in maxillary transport distraction was formed by intramembranous ossification and teeth in the transport segment remain viable after maxillary transport distraction osteogenesis. © 2004 American Association of Oral and Maxillofacial Surgeons.en_US
dc.languageengen_US
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/jomsen_US
dc.relation.ispartofJournal of Oral and Maxillofacial Surgeryen_US
dc.subject.meshAlveolar Process - Physiology - Surgeryen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBone Morphogenetic Proteins - Analysis - Biosynthesisen_US
dc.subject.meshBone Regeneration - Physiologyen_US
dc.subject.meshCollagen Type I - Biosynthesisen_US
dc.subject.meshCollagen Type Ii - Biosynthesisen_US
dc.subject.meshGingiva - Physiologyen_US
dc.subject.meshImmunoenzyme Techniquesen_US
dc.subject.meshMacaca Mulattaen_US
dc.subject.meshMaleen_US
dc.subject.meshMaxilla - Surgeryen_US
dc.subject.meshOsteoblasts - Metabolismen_US
dc.subject.meshOsteoclastsen_US
dc.subject.meshOsteogenesis, Distractionen_US
dc.titleHealing of Maxillary Alveolus in Transport Distraction Osteogenesis for Partial Maxillectomyen_US
dc.typeArticleen_US
dc.identifier.emailCheung, LK:lkcheung@hkucc.hku.hken_US
dc.identifier.authorityCheung, LK=rp00013en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.joms.2003.04.005en_US
dc.identifier.pmid14699552-
dc.identifier.scopuseid_2-s2.0-0347595354en_US
dc.identifier.hkuros93991-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0347595354&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume62en_US
dc.identifier.issue1en_US
dc.identifier.spage66en_US
dc.identifier.epage72en_US
dc.identifier.isiWOS:000187884900014-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridCheung, LK=7102302747en_US
dc.identifier.scopusauthoridZhang, Q=7407964515en_US

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