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Article: Surface characteristics of implants influence their bone integration after simultaneous placement of implant and GBR membrane

TitleSurface characteristics of implants influence their bone integration after simultaneous placement of implant and GBR membrane
Authors
Issue Date2003
PublisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CLR
Citation
Clinical Oral Implants Research, 2003, v. 14 n. 6, p. 669-679 How to Cite?
AbstractThe purpose of this study was to evaluate the influence of titanium surface characteristics on bone integration of implants, and to describe the pattern of peri-implant tissue healing after simultaneous implant placement and guided bone regeneration. In four healthy mongrel dogs mandibular premolars were extracted. Two weeks following full mouth prophylaxis and 4 months after extractions, simultaneous membrane and implant surgeries were performed. Efforts were made to produce bony defects with dimensions of 7 x 7 x 7 mm. Into these, 24 standard ITI® implants (Ø = 4.1 mm; length = 8 mm) with either a titanium plasma-sprayed (TPS) or a machined surface (MS) were placed. Although implants were inserted 4 mm into cancellous bone, difficulties in achieving optimal primary stability were encountered. All dogs were maintained on a soft diet. Chlorhexidine rinses were performed three times a week. Full mouth prophylaxis was performed every 2 weeks. In the case of membrane exposure, the membranes were removed prematurely (4-6 or 14-15 weeks after surgery). Two dogs were sacrificed at 16 weeks and two at 24 weeks after surgery. Nondecalcified histologic sections were processed and histometric analyses were carried out. When membranes were removed after 4-6 weeks, a vertical bone growth (VB) of 45-61% of the original defect was noted. After membrane removal at 14-15 weeks, similar VB was observed. However, if membranes were left in situ for 24 weeks, VB was between 79% and 96%. In this group of sites, the VB was 66% at 16 weeks and 86% at 24 weeks. Osseointegration in the regenerated bone area ranged from 12% to 32% for the TPS and from 0.0% to 3.6% for the MS implants at 16 and 24 weeks combined. Osseointegration in the pristine host bone area ranged from 16% to 35% for the TPS and from 0.0% to 11% for the MS sites at 16 and 24 weeks. In conclusion, the fraction of implant-bone integration was much higher in the pristine bone compared to that in the regenerated bone. TPS surfaces positively influenced the fraction of osseointegration in comparison to MS surfaces for both regenerated and pristine bone. Furthermore, early membrane removal negatively affected the fraction of bone defect fill.
Persistent Identifierhttp://hdl.handle.net/10722/154265
ISSN
2015 Impact Factor: 3.464
2015 SCImago Journal Rankings: 1.427
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLima, LAen_US
dc.contributor.authorFuchsWehrle, AMen_US
dc.contributor.authorLang, NPen_US
dc.contributor.authorHämmerle, CHFen_US
dc.contributor.authorLiberti, Een_US
dc.contributor.authorPompeu, Een_US
dc.contributor.authorTodescan, JHen_US
dc.date.accessioned2012-08-08T08:24:18Z-
dc.date.available2012-08-08T08:24:18Z-
dc.date.issued2003en_US
dc.identifier.citationClinical Oral Implants Research, 2003, v. 14 n. 6, p. 669-679en_US
dc.identifier.issn0905-7161en_US
dc.identifier.urihttp://hdl.handle.net/10722/154265-
dc.description.abstractThe purpose of this study was to evaluate the influence of titanium surface characteristics on bone integration of implants, and to describe the pattern of peri-implant tissue healing after simultaneous implant placement and guided bone regeneration. In four healthy mongrel dogs mandibular premolars were extracted. Two weeks following full mouth prophylaxis and 4 months after extractions, simultaneous membrane and implant surgeries were performed. Efforts were made to produce bony defects with dimensions of 7 x 7 x 7 mm. Into these, 24 standard ITI® implants (Ø = 4.1 mm; length = 8 mm) with either a titanium plasma-sprayed (TPS) or a machined surface (MS) were placed. Although implants were inserted 4 mm into cancellous bone, difficulties in achieving optimal primary stability were encountered. All dogs were maintained on a soft diet. Chlorhexidine rinses were performed three times a week. Full mouth prophylaxis was performed every 2 weeks. In the case of membrane exposure, the membranes were removed prematurely (4-6 or 14-15 weeks after surgery). Two dogs were sacrificed at 16 weeks and two at 24 weeks after surgery. Nondecalcified histologic sections were processed and histometric analyses were carried out. When membranes were removed after 4-6 weeks, a vertical bone growth (VB) of 45-61% of the original defect was noted. After membrane removal at 14-15 weeks, similar VB was observed. However, if membranes were left in situ for 24 weeks, VB was between 79% and 96%. In this group of sites, the VB was 66% at 16 weeks and 86% at 24 weeks. Osseointegration in the regenerated bone area ranged from 12% to 32% for the TPS and from 0.0% to 3.6% for the MS implants at 16 and 24 weeks combined. Osseointegration in the pristine host bone area ranged from 16% to 35% for the TPS and from 0.0% to 11% for the MS sites at 16 and 24 weeks. In conclusion, the fraction of implant-bone integration was much higher in the pristine bone compared to that in the regenerated bone. TPS surfaces positively influenced the fraction of osseointegration in comparison to MS surfaces for both regenerated and pristine bone. Furthermore, early membrane removal negatively affected the fraction of bone defect fill.en_US
dc.languageengen_US
dc.publisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CLRen_US
dc.relation.ispartofClinical Oral Implants Researchen_US
dc.subject.meshAlveolar Process - Pathology - Surgeryen_US
dc.subject.meshAlveolectomyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBicuspiden_US
dc.subject.meshBone Regeneration - Physiologyen_US
dc.subject.meshCoated Materials, Biocompatible - Chemistryen_US
dc.subject.meshDental Implantation, Endosseous - Instrumentation - Methodsen_US
dc.subject.meshDental Implantsen_US
dc.subject.meshDental Prosthesis Designen_US
dc.subject.meshDental Prosthesis Retentionen_US
dc.subject.meshDogsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGuided Tissue Regeneration, Periodontal - Methodsen_US
dc.subject.meshImplants, Experimentalen_US
dc.subject.meshMandible - Pathology - Surgeryen_US
dc.subject.meshMembranes, Artificialen_US
dc.subject.meshOsseointegration - Physiologyen_US
dc.subject.meshPolytetrafluoroethyleneen_US
dc.subject.meshSurface Propertiesen_US
dc.subject.meshTitanium - Chemistryen_US
dc.subject.meshTooth Extractionen_US
dc.subject.meshWound Healingen_US
dc.titleSurface characteristics of implants influence their bone integration after simultaneous placement of implant and GBR membraneen_US
dc.typeArticleen_US
dc.identifier.emailLang, NP:nplang@hkucc.hku.hken_US
dc.identifier.authorityLang, NP=rp00031en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1046/j.0905-7161.2003.00962.xen_US
dc.identifier.pmid15015941-
dc.identifier.scopuseid_2-s2.0-0347481279en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0347481279&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume14en_US
dc.identifier.issue6en_US
dc.identifier.spage669en_US
dc.identifier.epage679en_US
dc.identifier.isiWOS:000187107700001-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLima, LA=7102364941en_US
dc.identifier.scopusauthoridFuchsWehrle, AM=6507920166en_US
dc.identifier.scopusauthoridLang, NP=7201577367en_US
dc.identifier.scopusauthoridHämmerle, CHF=7005331848en_US
dc.identifier.scopusauthoridLiberti, E=35589037300en_US
dc.identifier.scopusauthoridPompeu, E=6508370487en_US
dc.identifier.scopusauthoridTodescan, JH=6603251398en_US

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