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Article: Forward mandibular positioning up-regulates SOX9 and type II collagen expression in the glenoid fossa

TitleForward mandibular positioning up-regulates SOX9 and type II collagen expression in the glenoid fossa
Authors
Rabie, ABMShe, TTHarley, VR
KeywordsForward mandibular positioning
Glenoid fossa
SOX9
Type II collagen
Issue Date2003
PublisherSage Publications, Inc.. The Journal's web site is located at http://www.sagepub.com/journalsProdDesc.nav?prodId=Journal201925
Citation
Journal Of Dental Research, 2003, v. 82 n. 9, p. 725-730 How to Cite?
DOI: http://dx.doi.org/10.1177/154405910308200913
AbstractRegulatory factors governing the formation of bone in the glenoid fossa in response to functional appliance therapy have not been identified. Therefore, the purpose of this study was to investigate the temporal pattern of expression of two key chondrogenesis markers - SOX9 and its target gene, type II collagen - in the glenoid fossa by immunostaining in a 35-day-old Sprague Dawley rat model during both natural growth and forward mandibular positioning. The expression of both factors was up-regulated when the mandible was positioned forward, indicating an enhancement of chondrocyte differentiation and chondroid matrix formation. Our results indicate that chondroid bone formation in the glenoid fossa in response to forward mandibular positioning is regulated by molecular markers indicative of endochondral ossification.
Persistent Identifierhttp://hdl.handle.net/10722/154253
ISSN
0022-0345
2021 Impact Factor: 8.924
2020 SCImago Journal Rankings: 1.979
ISI Accession Number ID
WOS:000185024500013
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorRabie, ABMen_HK
dc.contributor.authorShe, TTen_HK
dc.contributor.authorHarley, VRen_HK
dc.date.accessioned2012-08-08T08:24:12Z-
dc.date.available2012-08-08T08:24:12Z-
dc.date.issued2003en_HK
dc.identifier.citationJournal Of Dental Research, 2003, v. 82 n. 9, p. 725-730en_HK
dc.identifier.issn0022-0345en_HK
dc.identifier.urihttp://hdl.handle.net/10722/154253-
dc.description.abstractRegulatory factors governing the formation of bone in the glenoid fossa in response to functional appliance therapy have not been identified. Therefore, the purpose of this study was to investigate the temporal pattern of expression of two key chondrogenesis markers - SOX9 and its target gene, type II collagen - in the glenoid fossa by immunostaining in a 35-day-old Sprague Dawley rat model during both natural growth and forward mandibular positioning. The expression of both factors was up-regulated when the mandible was positioned forward, indicating an enhancement of chondrocyte differentiation and chondroid matrix formation. Our results indicate that chondroid bone formation in the glenoid fossa in response to forward mandibular positioning is regulated by molecular markers indicative of endochondral ossification.en_HK
dc.languageengen_US
dc.publisherSage Publications, Inc.. The Journal's web site is located at http://www.sagepub.com/journalsProdDesc.nav?prodId=Journal201925en_HK
dc.relation.ispartofJournal of Dental Researchen_HK
dc.subjectForward mandibular positioningen_HK
dc.subjectGlenoid fossaen_HK
dc.subjectSOX9en_HK
dc.subjectType II collagenen_HK
dc.subject.meshAnalysis Of Varianceen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCell Differentiation - Drug Effectsen_US
dc.subject.meshChondrocytes - Drug Effectsen_US
dc.subject.meshChondrogenesis - Drug Effectsen_US
dc.subject.meshCollagen Type Ii - Analysis - Geneticsen_US
dc.subject.meshExtracellular Matrix - Drug Effectsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHigh Mobility Group Proteins - Analysis - Geneticsen_US
dc.subject.meshMandible - Anatomy & Histology - Growth & Developmenten_US
dc.subject.meshModels, Animalen_US
dc.subject.meshOrthodontic Appliances, Functionalen_US
dc.subject.meshOsteogenesis - Drug Effectsen_US
dc.subject.meshRandom Allocationen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshSox9 Transcription Factoren_US
dc.subject.meshTemporal Bone - Growth & Development - Metabolismen_US
dc.subject.meshTranscription Factors - Analysis - Geneticsen_US
dc.subject.meshUp-Regulation - Geneticsen_US
dc.titleForward mandibular positioning up-regulates SOX9 and type II collagen expression in the glenoid fossaen_HK
dc.typeArticleen_HK
dc.identifier.emailRabie, ABM: rabie@hku.hken_HK
dc.identifier.authorityRabie, ABM=rp00029en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1177/154405910308200913-
dc.identifier.pmid12939358-
dc.identifier.scopuseid_2-s2.0-0141886975en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0141886975&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume82en_HK
dc.identifier.issue9en_HK
dc.identifier.spage725en_HK
dc.identifier.epage730en_HK
dc.identifier.isiWOS:000185024500013-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridRabie, ABM=7007172734en_HK
dc.identifier.scopusauthoridShe, TT=6602115149en_HK
dc.identifier.scopusauthoridHarley, VR=35465302100en_HK
dc.identifier.issnl0022-0345-

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