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Article: Phenotypic diversity of oral C. albicans isolated on single and sequential visits in an HIV-infected Chinese cohort

TitlePhenotypic diversity of oral C. albicans isolated on single and sequential visits in an HIV-infected Chinese cohort
Authors
Issue Date2003
PublisherWiley-Blackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journals/APMIS
Citation
APMIS, 2003, v. 111 n. 2, p. 329-337 How to Cite?
AbstractHIV-infected individuals maintain multiple oral C. albicans strains over time that are thought to undergo microevolution in terms of both phenotypic and genotypic features. To study this phenomenon, a 12-month prospective study was conducted in a cohort of 16 HIV-infected ethnic Chinese individuals with (A) and without (B) symptoms of oropharyngeal candidiasis to evaluate the phenotype distribution among oral C. albicans isolates during disease progression. Oral rinse samples were obtained and up to five C. albicans colony-forming units were selected per each visit, during the one year period of multiple visits. The isolates were phenotyped using two commercially available biotyping kits, the API 20C system, API ZYM system, and a plate test for resistance to boric acid. A total of 261 C. albicans strains in group A were differentiated into 67 biotypes, while 42 biotypes were seen amongst the 182 isolates from group B. The major biotypes in the two groups were similar and were in decreasing order of prevalence J1R, J1S, J6S, J6R, J2S, K1S, J10R, K1R, and K6R; 48 different biotypes were seen in group A and 24 in group B, with some uniquely represented in each group, leading to a significant association between the prevalence of the biotypes J1S and J2S and symptomatic candidiasis (p<0.05). Taken together this study illustrates the wide phenotypic spectrum of oral C. albicans associated with HIV-infection.
Persistent Identifierhttp://hdl.handle.net/10722/154239
ISSN
2015 Impact Factor: 1.933
2015 SCImago Journal Rankings: 0.855
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSamaranayake, YHen_US
dc.contributor.authorSamaranayake, LPen_US
dc.contributor.authorYau, JYYen_US
dc.contributor.authorDassanayake, RSen_US
dc.contributor.authorLi, TKLen_US
dc.contributor.authorAnil, Sen_US
dc.date.accessioned2012-08-08T08:24:07Z-
dc.date.available2012-08-08T08:24:07Z-
dc.date.issued2003en_US
dc.identifier.citationAPMIS, 2003, v. 111 n. 2, p. 329-337en_US
dc.identifier.issn0903-4641en_US
dc.identifier.urihttp://hdl.handle.net/10722/154239-
dc.description.abstractHIV-infected individuals maintain multiple oral C. albicans strains over time that are thought to undergo microevolution in terms of both phenotypic and genotypic features. To study this phenomenon, a 12-month prospective study was conducted in a cohort of 16 HIV-infected ethnic Chinese individuals with (A) and without (B) symptoms of oropharyngeal candidiasis to evaluate the phenotype distribution among oral C. albicans isolates during disease progression. Oral rinse samples were obtained and up to five C. albicans colony-forming units were selected per each visit, during the one year period of multiple visits. The isolates were phenotyped using two commercially available biotyping kits, the API 20C system, API ZYM system, and a plate test for resistance to boric acid. A total of 261 C. albicans strains in group A were differentiated into 67 biotypes, while 42 biotypes were seen amongst the 182 isolates from group B. The major biotypes in the two groups were similar and were in decreasing order of prevalence J1R, J1S, J6S, J6R, J2S, K1S, J10R, K1R, and K6R; 48 different biotypes were seen in group A and 24 in group B, with some uniquely represented in each group, leading to a significant association between the prevalence of the biotypes J1S and J2S and symptomatic candidiasis (p<0.05). Taken together this study illustrates the wide phenotypic spectrum of oral C. albicans associated with HIV-infection.en_US
dc.languageengen_US
dc.publisherWiley-Blackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journals/APMISen_US
dc.relation.ispartofAPMISen_US
dc.subject.meshAdulten_US
dc.subject.meshCandida Albicans - Classification - Genetics - Isolation & Purificationen_US
dc.subject.meshCandidiasis, Oral - Etiology - Microbiologyen_US
dc.subject.meshCarrier State - Microbiologyen_US
dc.subject.meshChinaen_US
dc.subject.meshCohort Studiesen_US
dc.subject.meshDisease Progressionen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHiv Infections - Complicationsen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshSexualityen_US
dc.titlePhenotypic diversity of oral C. albicans isolated on single and sequential visits in an HIV-infected Chinese cohorten_US
dc.typeArticleen_US
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0903-4641&volume=111&spage=329&epage=337&date=2002&atitle=Phenotypic+Diversity+of+Oral+C.+Ablicans+Isolated+on+Single+and+Sequential+Visits+in+an+HIV-infected+Chinese+Cohort-
dc.identifier.emailSamaranayake, YH: hema@hkucc.hku.hken_US
dc.identifier.emailSamaranayake, LP: lakshman@hku.hken_US
dc.identifier.emailYau, JYY: yaujyy@hkucc.hku.hk-
dc.identifier.emailLi, TKL: thomasli@hku.hk-
dc.identifier.authoritySamaranayake, YH=rp00025en_US
dc.identifier.authoritySamaranayake, LP=rp00023en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1034/j.1600-0463.2003.1110206.xen_US
dc.identifier.pmid12716390-
dc.identifier.scopuseid_2-s2.0-0038218119en_US
dc.identifier.hkuros76412-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0038218119&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume111en_US
dc.identifier.issue2en_US
dc.identifier.spage329en_US
dc.identifier.epage337en_US
dc.identifier.isiWOS:000182548300006-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridSamaranayake, YH=6602677237en_US
dc.identifier.scopusauthoridSamaranayake, LP=7102761002en_US
dc.identifier.scopusauthoridYau, JYY=7102167568en_US
dc.identifier.scopusauthoridDassanayake, RS=6603321318en_US
dc.identifier.scopusauthoridLi, TKL=24352391500en_US
dc.identifier.scopusauthoridAnil, S=7006640037en_US

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