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Article: Functional appliance therapy accelerates and enhances condylar growth

TitleFunctional appliance therapy accelerates and enhances condylar growth
Authors
Issue Date2003
PublisherMosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/ajodo
Citation
American Journal Of Orthodontics And Dentofacial Orthopedics, 2003, v. 123 n. 1, p. 40-48 How to Cite?
AbstractThe present study was designed to quantitatively assess the temporal pattern of expression of Sox 9, the regulator of chondrocyte differentiation and type II collagen, the major component of the cartilage matrix during forward mandibular positioning, and compare it with the expression during natural growth. Female Sprague-Dawley rats, 5 weeks old, were used. Results showed that the expression of Sox 9 and type II collagen are accelerated and enhanced when the mandible is positioned forward. Furthermore, we monitored the amount of new bone formation during mandibular advancement and after the removal of bite-jumping appliances. A substantial increase was observed in the amount of newly formed bone when the mandible was positioned forward. No significant difference in new bone formation could be found after the appliance was removed when compared with natural growth. Thus, functional appliance therapy accelerates and enhances condylar growth by accelerating the differentiation of mesenchymal cells into chondrocytes, leading to an earlier formation and increase in amount of cartilage matrix. This enhancement of growth did not result in a subsequent pattern of subnormal growth for most of the growth period; this indicates that functional appliance therapy can truly enhance condylar growth.
Persistent Identifierhttp://hdl.handle.net/10722/154225
ISSN
2015 Impact Factor: 1.69
2015 SCImago Journal Rankings: 1.249
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorRabie, ABMen_HK
dc.contributor.authorShe, TTen_HK
dc.contributor.authorHägg, Uen_HK
dc.date.accessioned2012-08-08T08:24:03Z-
dc.date.available2012-08-08T08:24:03Z-
dc.date.issued2003en_HK
dc.identifier.citationAmerican Journal Of Orthodontics And Dentofacial Orthopedics, 2003, v. 123 n. 1, p. 40-48en_HK
dc.identifier.issn0889-5406en_HK
dc.identifier.urihttp://hdl.handle.net/10722/154225-
dc.description.abstractThe present study was designed to quantitatively assess the temporal pattern of expression of Sox 9, the regulator of chondrocyte differentiation and type II collagen, the major component of the cartilage matrix during forward mandibular positioning, and compare it with the expression during natural growth. Female Sprague-Dawley rats, 5 weeks old, were used. Results showed that the expression of Sox 9 and type II collagen are accelerated and enhanced when the mandible is positioned forward. Furthermore, we monitored the amount of new bone formation during mandibular advancement and after the removal of bite-jumping appliances. A substantial increase was observed in the amount of newly formed bone when the mandible was positioned forward. No significant difference in new bone formation could be found after the appliance was removed when compared with natural growth. Thus, functional appliance therapy accelerates and enhances condylar growth by accelerating the differentiation of mesenchymal cells into chondrocytes, leading to an earlier formation and increase in amount of cartilage matrix. This enhancement of growth did not result in a subsequent pattern of subnormal growth for most of the growth period; this indicates that functional appliance therapy can truly enhance condylar growth.en_HK
dc.languageengen_US
dc.publisherMosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/ajodoen_HK
dc.relation.ispartofAmerican Journal of Orthodontics and Dentofacial Orthopedicsen_HK
dc.subject.meshActivator Appliancesen_US
dc.subject.meshAnalysis Of Varianceen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCell Differentiationen_US
dc.subject.meshChondrocytesen_US
dc.subject.meshChondrogenesis - Geneticsen_US
dc.subject.meshCollagen Type Ii - Biosynthesis - Geneticsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHigh Mobility Group Proteins - Biosynthesis - Geneticsen_US
dc.subject.meshMandibular Advancement - Instrumentationen_US
dc.subject.meshMandibular Condyle - Growth & Developmenten_US
dc.subject.meshMaxillofacial Development - Geneticsen_US
dc.subject.meshOsteogenesis - Geneticsen_US
dc.subject.meshRandom Allocationen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshSox9 Transcription Factoren_US
dc.subject.meshTranscription Factors - Biosynthesis - Geneticsen_US
dc.titleFunctional appliance therapy accelerates and enhances condylar growthen_HK
dc.typeArticleen_HK
dc.identifier.emailRabie, ABM: rabie@hku.hken_HK
dc.identifier.emailHägg, U: euohagg@hkusua.hku.hken_HK
dc.identifier.authorityRabie, ABM=rp00029en_HK
dc.identifier.authorityHägg, U=rp00020en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1067/mod.2003.45en_HK
dc.identifier.pmid12532062-
dc.identifier.scopuseid_2-s2.0-0037263945en_HK
dc.identifier.hkuros76152-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037263945&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume123en_HK
dc.identifier.issue1en_HK
dc.identifier.spage40en_HK
dc.identifier.epage48en_HK
dc.identifier.isiWOS:000180709000009-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridRabie, ABM=7007172734en_HK
dc.identifier.scopusauthoridShe, TT=6602115149en_HK
dc.identifier.scopusauthoridHägg, U=7006790279en_HK

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