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Article: Effects of mechanical stretching force on osteoblast-like function of human periodontal ligament cells in vitro

TitleEffects of mechanical stretching force on osteoblast-like function of human periodontal ligament cells in vitro
Authors
Issue Date2002
PublisherChinese Medical Association (中華醫學會). The Journal's web site is located at http://zhkqyx.periodicals.net.cn/default.html
Citation
Zhonghua Kou Qiang Yi Xue Za Zhi = Zhonghua Kouqiang Yixue Zazhi = Chinese Journal Of Stomatology, 2002, v. 37 n. 2, p. 135-138 How to Cite?
AbstractOBJECTIVE: To investigate the osteoblast-like functional characteristics exhibited by human periodontal ligament cells (hPDLCs) under mechanical force. METHODS: Human PDLCs cultured in vitro were stretched by mechanical force. Radioimmunoassay (RIA) was used to measure the expression of secreting alkaline phosphotase (ALP) and osteocalcin (OCN). The non-secreting ALP, OCN and osteopontin (OPN) in cells were determined by immunohistochemistry. RESULTS: It exhibited increasing of ALP secreted into conditional media, and in the 24 hour period there were two peaks which appeared at the 2nd and 4th hour and the 24th hour (P < 0.01). While in the late of the 24 hours, expression of OCN in conditional media increased (P < 0.05). CONCLUSION: Mechanical force induces hPDLCs to differentiate into functional osteoblast-like cells and plays a role in bone remodeling.
Persistent Identifierhttp://hdl.handle.net/10722/154191
ISSN
2015 SCImago Journal Rankings: 0.121

 

DC FieldValueLanguage
dc.contributor.authorLi, Xen_US
dc.contributor.authorZhang, Den_US
dc.contributor.authorFu, Men_US
dc.contributor.authorYang, Yen_US
dc.date.accessioned2012-08-08T08:23:47Z-
dc.date.available2012-08-08T08:23:47Z-
dc.date.issued2002en_US
dc.identifier.citationZhonghua Kou Qiang Yi Xue Za Zhi = Zhonghua Kouqiang Yixue Zazhi = Chinese Journal Of Stomatology, 2002, v. 37 n. 2, p. 135-138en_US
dc.identifier.issn1002-0098en_US
dc.identifier.urihttp://hdl.handle.net/10722/154191-
dc.description.abstractOBJECTIVE: To investigate the osteoblast-like functional characteristics exhibited by human periodontal ligament cells (hPDLCs) under mechanical force. METHODS: Human PDLCs cultured in vitro were stretched by mechanical force. Radioimmunoassay (RIA) was used to measure the expression of secreting alkaline phosphotase (ALP) and osteocalcin (OCN). The non-secreting ALP, OCN and osteopontin (OPN) in cells were determined by immunohistochemistry. RESULTS: It exhibited increasing of ALP secreted into conditional media, and in the 24 hour period there were two peaks which appeared at the 2nd and 4th hour and the 24th hour (P < 0.01). While in the late of the 24 hours, expression of OCN in conditional media increased (P < 0.05). CONCLUSION: Mechanical force induces hPDLCs to differentiate into functional osteoblast-like cells and plays a role in bone remodeling.en_US
dc.languageengen_US
dc.publisherChinese Medical Association (中華醫學會). The Journal's web site is located at http://zhkqyx.periodicals.net.cn/default.htmlen_US
dc.relation.ispartofZhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatologyen_US
dc.subject.meshAlkaline Phosphatase - Metabolismen_US
dc.subject.meshCells, Cultureden_US
dc.subject.meshHumansen_US
dc.subject.meshOsteocalcin - Analysisen_US
dc.subject.meshOsteoclasts - Physiologyen_US
dc.subject.meshOsteopontinen_US
dc.subject.meshPeriodontal Ligament - Cytologyen_US
dc.subject.meshSialoglycoproteins - Analysisen_US
dc.subject.meshStress, Mechanicalen_US
dc.titleEffects of mechanical stretching force on osteoblast-like function of human periodontal ligament cells in vitroen_US
dc.typeArticleen_US
dc.identifier.emailYang, Y:yangyanq@hkucc.hku.hken_US
dc.identifier.authorityYang, Y=rp00045en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid12475429-
dc.identifier.scopuseid_2-s2.0-0036490318en_US
dc.identifier.volume37en_US
dc.identifier.issue2en_US
dc.identifier.spage135en_US
dc.identifier.epage138en_US
dc.publisher.placeChinaen_US
dc.identifier.scopusauthoridLi, X=7501710811en_US
dc.identifier.scopusauthoridZhang, D=7405356257en_US
dc.identifier.scopusauthoridFu, M=7202031177en_US
dc.identifier.scopusauthoridYang, Y=36623085300en_US

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