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Article: A longitudinal study of interleukin-1 gene polymorphisms and periodontal disease in a general adult population

TitleA longitudinal study of interleukin-1 gene polymorphisms and periodontal disease in a general adult population
Authors
Issue Date2001
PublisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CPE
Citation
Journal Of Clinical Periodontology, 2001, v. 28 n. 12, p. 1137-1144 How to Cite?
AbstractBackground: Cross-sectional studies have demonstrated that a specific polymorphism (allele 2 of both IL-1A +4845 and IL-1B +3954) in the IL-1 gene cluster has been associated with an increased susceptibility to severe periodontal disease and to an increased bleeding tendency during periodontal maintenance. The aim of the present study was to investigate the relationship between IL-1 genotype and periodontitis in a prospective longitudinal study in an adult population of essentially European heritage. Methods: From an ongoing study of the Oral Care Research Programme of The University of Queensland, 295 subjects consented to genotyping for IL-1 allele 2 polymorphisms. Probing depths and relative attachment levels were recorded at baseline, 6, 12, 24, 36, 48 and 60 months using the Florida probe. Periodontitis progression at a given site was defined as attachment loss ≥2 mm at any observation period during the 5 years of the study and the extent of disease progression determined by the number of sites showing attachment loss. Porphyromonas gingivalis, Actinobacillus actinomycetemcomitans and Prevotella intermedia were detected using ELISA. Results: 38.9% of the subjects were positive for the composite IL-1 genotype. A relationship between the IL-1 positive genotype and increased mean probing pocket depth in non-smokers greater than 50 years of age was found. Further, IL-1 genotype positive smokers and genotype positive subjects with P. gingivalis in their plaque had an increase in the number of probing depths ≥3.5 mm. There was a consistent trend for IL-1 genotype positive subjects to experience attachment loss when compared with IL-1 genotype negative subjects. Conclusion: The results of this study have shown an interaction of the IL-1 positive genotype with age, smoking and P. gingivalis which suggests that IL-1 genotype is a contributory but non-essential risk factor for periodontal disease progression in this population. © Munksgaard, 2001.
Persistent Identifierhttp://hdl.handle.net/10722/154171
ISSN
2015 Impact Factor: 3.915
2015 SCImago Journal Rankings: 1.848
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCullinan, MPen_US
dc.contributor.authorWesterman, Ben_US
dc.contributor.authorHamlet, SMen_US
dc.contributor.authorPalmer, JEen_US
dc.contributor.authorFaddy, MJen_US
dc.contributor.authorLang, NPen_US
dc.contributor.authorSeymour, GJen_US
dc.date.accessioned2012-08-08T08:23:40Z-
dc.date.available2012-08-08T08:23:40Z-
dc.date.issued2001en_US
dc.identifier.citationJournal Of Clinical Periodontology, 2001, v. 28 n. 12, p. 1137-1144en_US
dc.identifier.issn0303-6979en_US
dc.identifier.urihttp://hdl.handle.net/10722/154171-
dc.description.abstractBackground: Cross-sectional studies have demonstrated that a specific polymorphism (allele 2 of both IL-1A +4845 and IL-1B +3954) in the IL-1 gene cluster has been associated with an increased susceptibility to severe periodontal disease and to an increased bleeding tendency during periodontal maintenance. The aim of the present study was to investigate the relationship between IL-1 genotype and periodontitis in a prospective longitudinal study in an adult population of essentially European heritage. Methods: From an ongoing study of the Oral Care Research Programme of The University of Queensland, 295 subjects consented to genotyping for IL-1 allele 2 polymorphisms. Probing depths and relative attachment levels were recorded at baseline, 6, 12, 24, 36, 48 and 60 months using the Florida probe. Periodontitis progression at a given site was defined as attachment loss ≥2 mm at any observation period during the 5 years of the study and the extent of disease progression determined by the number of sites showing attachment loss. Porphyromonas gingivalis, Actinobacillus actinomycetemcomitans and Prevotella intermedia were detected using ELISA. Results: 38.9% of the subjects were positive for the composite IL-1 genotype. A relationship between the IL-1 positive genotype and increased mean probing pocket depth in non-smokers greater than 50 years of age was found. Further, IL-1 genotype positive smokers and genotype positive subjects with P. gingivalis in their plaque had an increase in the number of probing depths ≥3.5 mm. There was a consistent trend for IL-1 genotype positive subjects to experience attachment loss when compared with IL-1 genotype negative subjects. Conclusion: The results of this study have shown an interaction of the IL-1 positive genotype with age, smoking and P. gingivalis which suggests that IL-1 genotype is a contributory but non-essential risk factor for periodontal disease progression in this population. © Munksgaard, 2001.en_US
dc.languageengen_US
dc.publisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CPEen_US
dc.relation.ispartofJournal of Clinical Periodontologyen_US
dc.subject.meshActinobacillus Actinomycetemcomitans - Isolation & Purificationen_US
dc.subject.meshAdulten_US
dc.subject.meshAge Factorsen_US
dc.subject.meshAustraliaen_US
dc.subject.meshDental Plaque - Microbiologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenetic Predisposition To Diseaseen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHumansen_US
dc.subject.meshInterleukin-1 - Geneticsen_US
dc.subject.meshLinear Modelsen_US
dc.subject.meshMaleen_US
dc.subject.meshPeriodontal Attachment Loss - Geneticsen_US
dc.subject.meshPeriodontitis - Geneticsen_US
dc.subject.meshPolymorphism, Geneticen_US
dc.subject.meshPorphyromonas Gingivalis - Isolation & Purificationen_US
dc.subject.meshPrevotella Intermedia - Isolation & Purificationen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshSmokingen_US
dc.titleA longitudinal study of interleukin-1 gene polymorphisms and periodontal disease in a general adult populationen_US
dc.typeArticleen_US
dc.identifier.emailLang, NP:nplang@hkucc.hku.hken_US
dc.identifier.authorityLang, NP=rp00031en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid11737511en_US
dc.identifier.scopuseid_2-s2.0-0035654518en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035654518&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume28en_US
dc.identifier.issue12en_US
dc.identifier.spage1137en_US
dc.identifier.epage1144en_US
dc.identifier.isiWOS:000172318200008-
dc.publisher.placeDenmarken_US
dc.identifier.scopusauthoridCullinan, MP=7004069335en_US
dc.identifier.scopusauthoridWesterman, B=7003398636en_US
dc.identifier.scopusauthoridHamlet, SM=7006308569en_US
dc.identifier.scopusauthoridPalmer, JE=9633078800en_US
dc.identifier.scopusauthoridFaddy, MJ=7003927846en_US
dc.identifier.scopusauthoridLang, NP=7201577367en_US
dc.identifier.scopusauthoridSeymour, GJ=7102909412en_US

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