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Article: Treatment of peri-implantitis by local delivery of tetracycline: Clinical, microbiological and radiological results

TitleTreatment of peri-implantitis by local delivery of tetracycline: Clinical, microbiological and radiological results
Authors
Issue Date2001
PublisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CLR
Citation
Clinical Oral Implants Research, 2001, v. 12 n. 4, p. 287-294 How to Cite?
AbstractThe purpose of this study was to investigate the clinical, microbiological and radiological effects of peri-implantitis therapy by local delivery of tetracycline. In 25 partially edentulous patients, 30 implants with radiographic evidence of circumferential bone loss, and peri-implant probing depths ≥5 mm were treated with polymeric tetracycline HCl-containing fibers. Clinical and microbial parameters were recorded at baseline, and 1, 3, 6, and 12 months (M) after treatment. Standardized radiographs were obtained at baseline, M3, and one year after treatment. Two patients were discontinued from the study after 180 days because of persisting active peri-implantitis with pus formation. The remaining subjects showed a significant decrease of mean peri-implant probing depth from 6.0 to 4.1 mm (M1, P<0.001), which was maintained over 12 months. In comparison to baseline, the bleeding tendency was significantly reduced after one month, and thereafter (P<0.001). No significant recession of the mucosal margin was noted. The radiologically determined distance from the shoulder of the implant to the bottom of the bony defect decreased slightly, but not significantly, from 5.2 to 4.9 mm. At M1, M3 and M6, mean total anaerobic cultivable bacterial counts were significantly lower than at baseline (P<0.001). A significant decrease in frequency of detection was noted for Prevotella intermedia/nigrescens, Fusobacterium sp., Bacteroides forsythus, and Campylobacter rectus (P<0.01). Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, and Eikenella corrodens had very low baseline frequencies that could not be significantly suppressed further. In conclusion, therapy of peri-implantitis by local delivery of tetracycline had a positive effect on clinical and microbiological parameters. Copyright © Munksgaard 2001.
Persistent Identifierhttp://hdl.handle.net/10722/154163
ISSN
2015 Impact Factor: 3.464
2015 SCImago Journal Rankings: 1.427
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMombelli, Aen_US
dc.contributor.authorFeloutzis, Aen_US
dc.contributor.authorBrägger, Uen_US
dc.contributor.authorLang, NPen_US
dc.date.accessioned2012-08-08T08:23:37Z-
dc.date.available2012-08-08T08:23:37Z-
dc.date.issued2001en_US
dc.identifier.citationClinical Oral Implants Research, 2001, v. 12 n. 4, p. 287-294en_US
dc.identifier.issn0905-7161en_US
dc.identifier.urihttp://hdl.handle.net/10722/154163-
dc.description.abstractThe purpose of this study was to investigate the clinical, microbiological and radiological effects of peri-implantitis therapy by local delivery of tetracycline. In 25 partially edentulous patients, 30 implants with radiographic evidence of circumferential bone loss, and peri-implant probing depths ≥5 mm were treated with polymeric tetracycline HCl-containing fibers. Clinical and microbial parameters were recorded at baseline, and 1, 3, 6, and 12 months (M) after treatment. Standardized radiographs were obtained at baseline, M3, and one year after treatment. Two patients were discontinued from the study after 180 days because of persisting active peri-implantitis with pus formation. The remaining subjects showed a significant decrease of mean peri-implant probing depth from 6.0 to 4.1 mm (M1, P<0.001), which was maintained over 12 months. In comparison to baseline, the bleeding tendency was significantly reduced after one month, and thereafter (P<0.001). No significant recession of the mucosal margin was noted. The radiologically determined distance from the shoulder of the implant to the bottom of the bony defect decreased slightly, but not significantly, from 5.2 to 4.9 mm. At M1, M3 and M6, mean total anaerobic cultivable bacterial counts were significantly lower than at baseline (P<0.001). A significant decrease in frequency of detection was noted for Prevotella intermedia/nigrescens, Fusobacterium sp., Bacteroides forsythus, and Campylobacter rectus (P<0.01). Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, and Eikenella corrodens had very low baseline frequencies that could not be significantly suppressed further. In conclusion, therapy of peri-implantitis by local delivery of tetracycline had a positive effect on clinical and microbiological parameters. Copyright © Munksgaard 2001.en_US
dc.languageengen_US
dc.publisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CLRen_US
dc.relation.ispartofClinical Oral Implants Researchen_US
dc.subject.meshAdministration, Topicalen_US
dc.subject.meshAlveolar Bone Loss - Etiology - Radiographyen_US
dc.subject.meshAnti-Bacterial Agents - Administration & Dosageen_US
dc.subject.meshBacteria, Anaerobic - Drug Effectsen_US
dc.subject.meshBiocompatible Materials - Administration & Dosageen_US
dc.subject.meshCellulose - Administration & Dosageen_US
dc.subject.meshColony Count, Microbialen_US
dc.subject.meshDental Implants - Adverse Effects - Microbiologyen_US
dc.subject.meshDrug Delivery Systemsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGram-Negative Bacteria - Drug Effectsen_US
dc.subject.meshHumansen_US
dc.subject.meshLinear Modelsen_US
dc.subject.meshMaleen_US
dc.subject.meshPeriodontitis - Drug Therapy - Etiology - Microbiologyen_US
dc.subject.meshProsthesis-Related Infections - Drug Therapyen_US
dc.subject.meshStatistics, Nonparametricen_US
dc.subject.meshTetracycline - Administration & Dosageen_US
dc.titleTreatment of peri-implantitis by local delivery of tetracycline: Clinical, microbiological and radiological resultsen_US
dc.typeArticleen_US
dc.identifier.emailLang, NP:nplang@hkucc.hku.hken_US
dc.identifier.authorityLang, NP=rp00031en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid11488856en_US
dc.identifier.scopuseid_2-s2.0-0035434744en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035434744&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume12en_US
dc.identifier.issue4en_US
dc.identifier.spage287en_US
dc.identifier.epage294en_US
dc.identifier.isiWOS:000169973200001-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridMombelli, A=7006180872en_US
dc.identifier.scopusauthoridFeloutzis, A=6508158601en_US
dc.identifier.scopusauthoridBrägger, U=7005538598en_US
dc.identifier.scopusauthoridLang, NP=7201577367en_US

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