File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Soluble CD14 levels in gingival crevicular fluid of subjects with untreated adult periodontitis

TitleSoluble CD14 levels in gingival crevicular fluid of subjects with untreated adult periodontitis
Authors
Issue Date2001
PublisherAmerican Academy of Periodontology. The Journal's web site is located at http://www.perio.org
Citation
Journal Of Periodontology, 2001, v. 72 n. 5, p. 634-640 How to Cite?
AbstractBackground: This study determined soluble CD14 (sCD14) levels in gingival crevicular fluid (GCF) and their potential relationship to periodontal conditions in adult periodontitis. Methods: QCF was collected from 15 patients with untreated adult periodontitis. sCD14 levels were determined by ELISA and presented as total amount (ng/site) and concentration (μg/ml). The periodontal examination consisted of plaque index (PI), bleeding index (BI), probing depth (PD), and clinical attachment level (CAL). PD and CAL were measured with an electronic probe. Results: sCD14 was detected in all 15 subjects and was found in 59% (62/105) of the sampled sites. The percentage of sites with sCD14 varied greatly, ranging from 14% to 100%. The mean total amount of sCD14 was 1.71 ± 0.40, range 0.03 to 5.41 ng/site; the concentration of sCD14 was 14.04 ± 4.15, range 0.16 to 51.74 (μ/ml. No significant difference in clinical data was found between the sites with and without detectable levels of sCD14. However, on the basis of the individual profile of sCD14 levels, i.e., those individuals with > 50% of the sites containing sCD14 and mean levels of sCD14 >5.0 μg/ml, the 15 subjects were divided into a high sCD14 group (9 subjects) and a low sCD14 group (6 subjects). Compared to the high group, the low group showed greater mean PD and a higher percentage of sites with PD ≥ 5.0 mm (P<0.05). Consistent with this, sCD14 concentrations showed a negative correlation with PD (rs =-0.636, P =0.0174). Conclusions: The present study shows that sCD14 levels in GCF varied greatly among subjects with untreated adult periodontitis. Individuals with higher levels of sCD14 in GCF and more sites containing sCD14 had fewer deep pockets. The negative correlation between GCF sCD14 levels and probing depth implies a crucial role of sCD14 in bacterially induced periodontal destruction. The relationship between GCF sCD14 levels and probing depth warrants further investigations.
Persistent Identifierhttp://hdl.handle.net/10722/154156
ISSN
2015 Impact Factor: 2.844
2015 SCImago Journal Rankings: 1.070
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorJin, Len_US
dc.contributor.authorDarveau, RPen_US
dc.date.accessioned2012-08-08T08:23:35Z-
dc.date.available2012-08-08T08:23:35Z-
dc.date.issued2001en_US
dc.identifier.citationJournal Of Periodontology, 2001, v. 72 n. 5, p. 634-640en_US
dc.identifier.issn0022-3492en_US
dc.identifier.urihttp://hdl.handle.net/10722/154156-
dc.description.abstractBackground: This study determined soluble CD14 (sCD14) levels in gingival crevicular fluid (GCF) and their potential relationship to periodontal conditions in adult periodontitis. Methods: QCF was collected from 15 patients with untreated adult periodontitis. sCD14 levels were determined by ELISA and presented as total amount (ng/site) and concentration (μg/ml). The periodontal examination consisted of plaque index (PI), bleeding index (BI), probing depth (PD), and clinical attachment level (CAL). PD and CAL were measured with an electronic probe. Results: sCD14 was detected in all 15 subjects and was found in 59% (62/105) of the sampled sites. The percentage of sites with sCD14 varied greatly, ranging from 14% to 100%. The mean total amount of sCD14 was 1.71 ± 0.40, range 0.03 to 5.41 ng/site; the concentration of sCD14 was 14.04 ± 4.15, range 0.16 to 51.74 (μ/ml. No significant difference in clinical data was found between the sites with and without detectable levels of sCD14. However, on the basis of the individual profile of sCD14 levels, i.e., those individuals with > 50% of the sites containing sCD14 and mean levels of sCD14 >5.0 μg/ml, the 15 subjects were divided into a high sCD14 group (9 subjects) and a low sCD14 group (6 subjects). Compared to the high group, the low group showed greater mean PD and a higher percentage of sites with PD ≥ 5.0 mm (P<0.05). Consistent with this, sCD14 concentrations showed a negative correlation with PD (rs =-0.636, P =0.0174). Conclusions: The present study shows that sCD14 levels in GCF varied greatly among subjects with untreated adult periodontitis. Individuals with higher levels of sCD14 in GCF and more sites containing sCD14 had fewer deep pockets. The negative correlation between GCF sCD14 levels and probing depth implies a crucial role of sCD14 in bacterially induced periodontal destruction. The relationship between GCF sCD14 levels and probing depth warrants further investigations.en_US
dc.languageengen_US
dc.publisherAmerican Academy of Periodontology. The Journal's web site is located at http://www.perio.orgen_US
dc.relation.ispartofJournal of Periodontologyen_US
dc.subject.meshAdulten_US
dc.subject.meshAlveolar Bone Loss - Classification - Immunologyen_US
dc.subject.meshAnalysis Of Varianceen_US
dc.subject.meshAntibodies, Monoclonal - Diagnostic Useen_US
dc.subject.meshAntigens, Cd14 - Analysisen_US
dc.subject.meshDental Plaque Indexen_US
dc.subject.meshEnzyme-Linked Immunosorbent Assayen_US
dc.subject.meshGingival Crevicular Fluid - Immunologyen_US
dc.subject.meshGingival Hemorrhage - Classification - Immunologyen_US
dc.subject.meshHumansen_US
dc.subject.meshLinear Modelsen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNormal Distributionen_US
dc.subject.meshPeriodontal Attachment Loss - Classification - Immunologyen_US
dc.subject.meshPeriodontal Indexen_US
dc.subject.meshPeriodontal Pocket - Classification - Immunologyen_US
dc.subject.meshPeriodontitis - Immunologyen_US
dc.subject.meshStatistics, Nonparametricen_US
dc.titleSoluble CD14 levels in gingival crevicular fluid of subjects with untreated adult periodontitisen_US
dc.typeArticleen_US
dc.identifier.emailJin, L:ljjin@hkucc.hku.hken_US
dc.identifier.authorityJin, L=rp00028en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1902/jop.2001.72.5.634en_US
dc.identifier.pmid11394399-
dc.identifier.scopuseid_2-s2.0-0035348441en_US
dc.identifier.hkuros58177-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035348441&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume72en_US
dc.identifier.issue5en_US
dc.identifier.spage634en_US
dc.identifier.epage640en_US
dc.identifier.isiWOS:000168908600009-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridJin, L=7403328850en_US
dc.identifier.scopusauthoridDarveau, RP=7006419856en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats