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Article: Correlation between the expression of cyclin A protein and p53 activity in oral squamous cell carcinomas

TitleCorrelation between the expression of cyclin A protein and p53 activity in oral squamous cell carcinomas
Authors
Issue Date2001
PublisherUniversity of Cambridge, Faculty Press.
Citation
Cytobios, 2001, v. 106 n. 412, p. 87-99 How to Cite?
AbstractCyclins and wild-type p53 protein are prime cell cycle regulators and may be involved in tumorigenesis. Cyclin A is a late S cyclin and its abnormalities have been reported in several cancers, including oral squamous cell carcinomas. To explore whether aberrant G1/S in p53 mutant tumours leads to increased cyclin A protein in oral squamous cell carcinomas (OSCC), a total of 39 samples were evaluated for the expression of cyclin A and p53 protein by an immunohistochemical method using a labelled polymer assay. These samples comprised two hyperkeratotic and three oral premalignant lesions (two moderate and one severe dysplastic lesions), and 27 OSCC, together with seven healthy controls. The results demonstrated that the cyclin A protein was localized and highly expressed in the nuclei of the tumour cells. Although there was no correlation between cyclin A detection and the local lymph node involvement, a positive correlation was noted between the positivity of cyclin A and p53 protein (p <0.05). The results suggested that cyclin A may contribute to the progression of oral cancer and correlated to some degree with that of the p53 gene activity.
Persistent Identifierhttp://hdl.handle.net/10722/154149
ISSN
2003 Impact Factor: 0.486
2004 SCImago Journal Rankings: 0.175
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChen, Qen_US
dc.contributor.authorZhou, Hen_US
dc.contributor.authorGuo, Wen_US
dc.contributor.authorSamaranayake, LPen_US
dc.contributor.authorZhou, Men_US
dc.contributor.authorLi, Ben_US
dc.date.accessioned2012-08-08T08:23:32Z-
dc.date.available2012-08-08T08:23:32Z-
dc.date.issued2001en_US
dc.identifier.citationCytobios, 2001, v. 106 n. 412, p. 87-99en_US
dc.identifier.issn0011-4529en_US
dc.identifier.urihttp://hdl.handle.net/10722/154149-
dc.description.abstractCyclins and wild-type p53 protein are prime cell cycle regulators and may be involved in tumorigenesis. Cyclin A is a late S cyclin and its abnormalities have been reported in several cancers, including oral squamous cell carcinomas. To explore whether aberrant G1/S in p53 mutant tumours leads to increased cyclin A protein in oral squamous cell carcinomas (OSCC), a total of 39 samples were evaluated for the expression of cyclin A and p53 protein by an immunohistochemical method using a labelled polymer assay. These samples comprised two hyperkeratotic and three oral premalignant lesions (two moderate and one severe dysplastic lesions), and 27 OSCC, together with seven healthy controls. The results demonstrated that the cyclin A protein was localized and highly expressed in the nuclei of the tumour cells. Although there was no correlation between cyclin A detection and the local lymph node involvement, a positive correlation was noted between the positivity of cyclin A and p53 protein (p <0.05). The results suggested that cyclin A may contribute to the progression of oral cancer and correlated to some degree with that of the p53 gene activity.en_US
dc.languageengen_US
dc.publisherUniversity of Cambridge, Faculty Press.-
dc.relation.ispartofCytobiosen_US
dc.subject.meshCarcinoma, Squamous Cell - Metabolism - Pathologyen_US
dc.subject.meshCyclin A - Metabolismen_US
dc.subject.meshG1 Phase - Physiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshLymph Nodes - Physiopathologyen_US
dc.subject.meshMouth Neoplasms - Metabolism - Pathologyen_US
dc.subject.meshMutation - Geneticsen_US
dc.subject.meshPilot Projectsen_US
dc.subject.meshS Phase - Physiologyen_US
dc.subject.meshTumor Suppressor Protein P53 - Genetics - Metabolismen_US
dc.titleCorrelation between the expression of cyclin A protein and p53 activity in oral squamous cell carcinomasen_US
dc.typeArticleen_US
dc.identifier.emailSamaranayake, LP:lakshman@hku.hken_US
dc.identifier.authoritySamaranayake, LP=rp00023en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid11503976en_US
dc.identifier.scopuseid_2-s2.0-0035237931en_US
dc.identifier.hkuros64909-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035237931&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume106en_US
dc.identifier.issue412en_US
dc.identifier.spage87en_US
dc.identifier.epage99en_US
dc.identifier.isiWOS:000170774900002-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridChen, Q=16244214800en_US
dc.identifier.scopusauthoridZhou, H=38062651500en_US
dc.identifier.scopusauthoridGuo, W=34769867800en_US
dc.identifier.scopusauthoridSamaranayake, LP=7102761002en_US
dc.identifier.scopusauthoridZhou, M=23476310200en_US
dc.identifier.scopusauthoridLi, B=7410080736en_US

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