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Article: Homozygous deletion of the PTEN tumor-suppressor gene is not a feature in oral squamous cell carcinoma

TitleHomozygous deletion of the PTEN tumor-suppressor gene is not a feature in oral squamous cell carcinoma
Authors
Issue Date2000
PublisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/oraloncology
Citation
Oral Oncology, 2000, v. 36 n. 1, p. 95-99 How to Cite?
AbstractA recently identified putative tumor-suppressor gene, PTEN, at 10q23 has been described as mutated or homozygously deleted in many different human tumors. To determine the role of the homozygous deletion of this PTEN gene in oral squamous cell carcinoma (OSCC), we screened two cell lines derived from the latter tissue and 28 tumor samples from patients with OSCC, using a differential display polymerase chain reaction (PCR) system and, direct DNA sequencing methods. All of the nine exons of the PTEN could be successfully amplified using DNA from tumor tissues and the cell lines using this system. DNA sequencing confirmed the accuracy of the PCR procedures. However, none of the samples, either from the cancer tissues or from the cell lines, showed homozygous deletion of PTEN. These data suggest that homozygous deletion of the PTEN gene is unlikely to be a feature of OSCCs. Copyright (C) 2000 Elsevier Science Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/154090
ISSN
2015 Impact Factor: 4.286
2015 SCImago Journal Rankings: 1.764
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChen, Qen_US
dc.contributor.authorSamaranayake, LPen_US
dc.contributor.authorZhou, Hen_US
dc.contributor.authorXiao, Len_US
dc.date.accessioned2012-08-08T08:23:13Z-
dc.date.available2012-08-08T08:23:13Z-
dc.date.issued2000en_US
dc.identifier.citationOral Oncology, 2000, v. 36 n. 1, p. 95-99en_US
dc.identifier.issn1368-8375en_US
dc.identifier.urihttp://hdl.handle.net/10722/154090-
dc.description.abstractA recently identified putative tumor-suppressor gene, PTEN, at 10q23 has been described as mutated or homozygously deleted in many different human tumors. To determine the role of the homozygous deletion of this PTEN gene in oral squamous cell carcinoma (OSCC), we screened two cell lines derived from the latter tissue and 28 tumor samples from patients with OSCC, using a differential display polymerase chain reaction (PCR) system and, direct DNA sequencing methods. All of the nine exons of the PTEN could be successfully amplified using DNA from tumor tissues and the cell lines using this system. DNA sequencing confirmed the accuracy of the PCR procedures. However, none of the samples, either from the cancer tissues or from the cell lines, showed homozygous deletion of PTEN. These data suggest that homozygous deletion of the PTEN gene is unlikely to be a feature of OSCCs. Copyright (C) 2000 Elsevier Science Ltd.en_US
dc.languageengen_US
dc.publisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/oraloncologyen_US
dc.relation.ispartofOral Oncologyen_US
dc.subject.meshAgeden_US
dc.subject.meshCarcinoma, Squamous Cell - Geneticsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGene Deletionen_US
dc.subject.meshGenes, Tumor Suppressor - Geneticsen_US
dc.subject.meshHomozygoteen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMouth Neoplasms - Geneticsen_US
dc.subject.meshMutation - Geneticsen_US
dc.subject.meshPten Phosphohydrolaseen_US
dc.subject.meshPhosphoric Monoester Hydrolases - Genetics - Metabolismen_US
dc.subject.meshTumor Suppressor Proteinsen_US
dc.titleHomozygous deletion of the PTEN tumor-suppressor gene is not a feature in oral squamous cell carcinomaen_US
dc.typeArticleen_US
dc.identifier.emailSamaranayake, LP:lakshman@hku.hken_US
dc.identifier.authoritySamaranayake, LP=rp00023en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S1368-8375(99)00068-8en_US
dc.identifier.pmid10889927-
dc.identifier.scopuseid_2-s2.0-0033991192en_US
dc.identifier.hkuros47865-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033991192&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume36en_US
dc.identifier.issue1en_US
dc.identifier.spage95en_US
dc.identifier.epage99en_US
dc.identifier.isiWOS:000084796400017-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridChen, Q=16244214800en_US
dc.identifier.scopusauthoridSamaranayake, LP=7102761002en_US
dc.identifier.scopusauthoridZhou, H=7404742966en_US
dc.identifier.scopusauthoridXiao, L=55244431500en_US

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