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Article: Attempts to obtain re-osseointegration following experimental peri-implantitis in dogs

TitleAttempts to obtain re-osseointegration following experimental peri-implantitis in dogs
Authors
Issue Date1999
PublisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CLR
Citation
Clinical Oral Implants Research, 1999, v. 10 n. 2, p. 111-119 How to Cite?
AbstractThe purpose of this study was to examine the healing potential and reosseointegration in peri-implant infection defects adjacent to various implant surfaces. In 7 female Beagle dogs, a total of 41 titanium oral implants (ITI, Straumann, Waldenburg; Switzerland) with a sink depth of 6 mm (diameter 2.8 mm) were placed transmucosally. Four different surface configurations (TPS: titanium plasma sprayed (10); SLA: sand blasted and acid-etched (13); M: machined and smooth (11); TPS furc.: titanium plasma sprayed with coronally placed perforation to mimic a furcation (7) were distributed among the animals and locations. Following a healing period of 3 months, silk ligatures were placed and oral cleaning procedures abolished for 4 months to induce a vertical bone loss of about 40%. Following mechanical and chemical cleansing (chlorhexidine and metronidazole) and disinfection, the lesions were either sham operated (11) or subjected to a GTR procedure using ePTFE (30). After 6 months of healing the animals were killed and the jaws histologically evaluated. Six membranes were lost TPS: (1); SLA: (2); M: (2); TPS furc: (1) and 3 membranes exposed TPS: (1); M: (2) and excluded from further evaluation. Owing to the loss of 1 implant and infection of the membranes in the TPS furc group, this implant configuration was discarded from further analysis. For TPS surfaces, bone fill was 2.6 mm (73% of the distance from the bottom of the defect to the shoulder of the implant) sites with (4 GTR) and 0.33 mm (14%) for sites without membrane (2 controls). Re-osseointegration was 0.5 mm (14%) in the test group and 0.3 mm (14%) in the control. For SLA surfaces bone fill was 2.3 mm (83%) for sites with (7 GTR) and 0.41 mm (15%) for sites without membranes (4 controls). Re-osseointegration was 0.6 mm (20%) and 0.3 mm (11%) respectively. Corresponding values for M surfaces were 2.2 mm (62%) with 4 GTR) and 0.82 mm (31%) without membranes. Re-osseointegration was 0.07 mm (2%) and 0.19 mm (7%) respectively. This study has documented that peri-implant infections defects may heal with bone fill provided that the infection is controlled through effective antibacterial therapy. However, true reosseointegration appears to be difficult to achieve. Copyright © Munksgaard 1999.
Persistent Identifierhttp://hdl.handle.net/10722/154061
ISSN
2015 Impact Factor: 3.464
2015 SCImago Journal Rankings: 1.427
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWetzel, ACen_US
dc.contributor.authorVlassis, Jen_US
dc.contributor.authorCaffesse, RGen_US
dc.contributor.authorHämmerle, CHFen_US
dc.contributor.authorLang, NPen_US
dc.date.accessioned2012-08-08T08:23:04Z-
dc.date.available2012-08-08T08:23:04Z-
dc.date.issued1999en_US
dc.identifier.citationClinical Oral Implants Research, 1999, v. 10 n. 2, p. 111-119en_US
dc.identifier.issn0905-7161en_US
dc.identifier.urihttp://hdl.handle.net/10722/154061-
dc.description.abstractThe purpose of this study was to examine the healing potential and reosseointegration in peri-implant infection defects adjacent to various implant surfaces. In 7 female Beagle dogs, a total of 41 titanium oral implants (ITI, Straumann, Waldenburg; Switzerland) with a sink depth of 6 mm (diameter 2.8 mm) were placed transmucosally. Four different surface configurations (TPS: titanium plasma sprayed (10); SLA: sand blasted and acid-etched (13); M: machined and smooth (11); TPS furc.: titanium plasma sprayed with coronally placed perforation to mimic a furcation (7) were distributed among the animals and locations. Following a healing period of 3 months, silk ligatures were placed and oral cleaning procedures abolished for 4 months to induce a vertical bone loss of about 40%. Following mechanical and chemical cleansing (chlorhexidine and metronidazole) and disinfection, the lesions were either sham operated (11) or subjected to a GTR procedure using ePTFE (30). After 6 months of healing the animals were killed and the jaws histologically evaluated. Six membranes were lost TPS: (1); SLA: (2); M: (2); TPS furc: (1) and 3 membranes exposed TPS: (1); M: (2) and excluded from further evaluation. Owing to the loss of 1 implant and infection of the membranes in the TPS furc group, this implant configuration was discarded from further analysis. For TPS surfaces, bone fill was 2.6 mm (73% of the distance from the bottom of the defect to the shoulder of the implant) sites with (4 GTR) and 0.33 mm (14%) for sites without membrane (2 controls). Re-osseointegration was 0.5 mm (14%) in the test group and 0.3 mm (14%) in the control. For SLA surfaces bone fill was 2.3 mm (83%) for sites with (7 GTR) and 0.41 mm (15%) for sites without membranes (4 controls). Re-osseointegration was 0.6 mm (20%) and 0.3 mm (11%) respectively. Corresponding values for M surfaces were 2.2 mm (62%) with 4 GTR) and 0.82 mm (31%) without membranes. Re-osseointegration was 0.07 mm (2%) and 0.19 mm (7%) respectively. This study has documented that peri-implant infections defects may heal with bone fill provided that the infection is controlled through effective antibacterial therapy. However, true reosseointegration appears to be difficult to achieve. Copyright © Munksgaard 1999.en_US
dc.languageengen_US
dc.publisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CLRen_US
dc.relation.ispartofClinical Oral Implants Researchen_US
dc.subject.meshAlveolar Process - Physiologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnti-Infective Agents - Therapeutic Useen_US
dc.subject.meshBone Regenerationen_US
dc.subject.meshChlorhexidine - Therapeutic Useen_US
dc.subject.meshDental Implants - Adverse Effectsen_US
dc.subject.meshDental Plaque - Complicationsen_US
dc.subject.meshDental Prosthesis Designen_US
dc.subject.meshDogsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGuided Tissue Regeneration, Periodontalen_US
dc.subject.meshMembranes, Artificialen_US
dc.subject.meshMetronidazole - Therapeutic Useen_US
dc.subject.meshOsseointegrationen_US
dc.subject.meshPeriodontitis - Etiology - Therapyen_US
dc.subject.meshPolytetrafluoroethyleneen_US
dc.subject.meshProsthesis-Related Infections - Drug Therapy - Etiologyen_US
dc.subject.meshRetreatmenten_US
dc.subject.meshStatistics, Nonparametricen_US
dc.subject.meshWound Healingen_US
dc.titleAttempts to obtain re-osseointegration following experimental peri-implantitis in dogsen_US
dc.typeArticleen_US
dc.identifier.emailLang, NP:nplang@hkucc.hku.hken_US
dc.identifier.authorityLang, NP=rp00031en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid10219130-
dc.identifier.scopuseid_2-s2.0-0033112622en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033112622&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume10en_US
dc.identifier.issue2en_US
dc.identifier.spage111en_US
dc.identifier.epage119en_US
dc.identifier.isiWOS:000079274100005-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridWetzel, AC=7005517529en_US
dc.identifier.scopusauthoridVlassis, J=6603564958en_US
dc.identifier.scopusauthoridCaffesse, RG=7005708068en_US
dc.identifier.scopusauthoridHämmerle, CHF=7005331848en_US
dc.identifier.scopusauthoridLang, NP=7201577367en_US

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