File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Generalizability of the Added Benefits of Guided Tissue Regeneration in the Treatment of Deep Intrabony Defects. Evaluation in a Multi-Center Randomized Controlled Clinical Trial

TitleGeneralizability of the Added Benefits of Guided Tissue Regeneration in the Treatment of Deep Intrabony Defects. Evaluation in a Multi-Center Randomized Controlled Clinical Trial
Authors
Issue Date1998
PublisherAmerican Academy of Periodontology. The Journal's web site is located at http://www.perio.org
Citation
Journal Of Periodontology, 1998, v. 69 n. 11, p. 1183-1192 How to Cite?
AbstractBackground: Several studies have shown that GTR therapy of intrabony defects results in significantly better outcomes than access flap alone. Most of the available data, however, have been produced in highly controlled research environments by a small group of investigators. Generalizability of results to different clinicians and different subject populations has not been evaluated so far. Methods: This parallel group study involved 143 patients recruited in a practicebased research network of 11 offices in 7 countries. It was designed to evaluate: 1) the applicability of the documented added benefits of GTR in the treatment of intrabony defects to different populations, and 2) the generalizability of the expected results to different clinicians. GTR was compared to access flap alone. Defects, one in each patient, were accessed with a previously described papilla preservation flap in both the test and control group. In addition, GTR sites received application of a bioabsorbable poly-D,L-lactide-co-glycolide membrane. A stringent plaque control regimen was enforced in all patients during the 1-year observation period. Outcomes included gains in clinical attachment (CAL) and reductions in probing depth. Results: Observed gains in CAL were 2.18 ± 1.46 mm for access flap and 3.04 ± 1.64 mm for the GTR-treated group. The treatment-associated difference was statistically significant (P = 0.03) after correcting for both center effect and defect anatomy. Among the various centers, a 1.73 mm difference in CAL gain was observed. This is a clinically relevant amount, which underlines the significance of center variability in the outcome of periodontal surgical procedures. A frequency distribution analysis of the obtained CAL gains indicated that GTR treatment of deep intrabony defects decreased, with respect to the access flap control, the probability of obtaining only a modest attachment gain at 1 year. Conversely, CAL gains of 4 mm or more were.
Persistent Identifierhttp://hdl.handle.net/10722/154042
ISSN
2015 Impact Factor: 2.844
2015 SCImago Journal Rankings: 1.070
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTonetti, MSen_US
dc.contributor.authorCortellini, Pen_US
dc.contributor.authorSuvan, JEen_US
dc.contributor.authorAdriaens, Pen_US
dc.contributor.authorBaldi, Cen_US
dc.contributor.authorDubravec, Den_US
dc.contributor.authorFonzar, Aen_US
dc.contributor.authorFourmousis, Ien_US
dc.contributor.authorMagnani, Cen_US
dc.contributor.authorMullerCampanile, Ven_US
dc.contributor.authorPatroni, Sen_US
dc.contributor.authorSanz, Men_US
dc.contributor.authorVangsted, Ten_US
dc.contributor.authorZabalegui, Ien_US
dc.contributor.authorPrato, GPen_US
dc.contributor.authorLang, NPen_US
dc.date.accessioned2012-08-08T08:22:58Z-
dc.date.available2012-08-08T08:22:58Z-
dc.date.issued1998en_US
dc.identifier.citationJournal Of Periodontology, 1998, v. 69 n. 11, p. 1183-1192en_US
dc.identifier.issn0022-3492en_US
dc.identifier.urihttp://hdl.handle.net/10722/154042-
dc.description.abstractBackground: Several studies have shown that GTR therapy of intrabony defects results in significantly better outcomes than access flap alone. Most of the available data, however, have been produced in highly controlled research environments by a small group of investigators. Generalizability of results to different clinicians and different subject populations has not been evaluated so far. Methods: This parallel group study involved 143 patients recruited in a practicebased research network of 11 offices in 7 countries. It was designed to evaluate: 1) the applicability of the documented added benefits of GTR in the treatment of intrabony defects to different populations, and 2) the generalizability of the expected results to different clinicians. GTR was compared to access flap alone. Defects, one in each patient, were accessed with a previously described papilla preservation flap in both the test and control group. In addition, GTR sites received application of a bioabsorbable poly-D,L-lactide-co-glycolide membrane. A stringent plaque control regimen was enforced in all patients during the 1-year observation period. Outcomes included gains in clinical attachment (CAL) and reductions in probing depth. Results: Observed gains in CAL were 2.18 ± 1.46 mm for access flap and 3.04 ± 1.64 mm for the GTR-treated group. The treatment-associated difference was statistically significant (P = 0.03) after correcting for both center effect and defect anatomy. Among the various centers, a 1.73 mm difference in CAL gain was observed. This is a clinically relevant amount, which underlines the significance of center variability in the outcome of periodontal surgical procedures. A frequency distribution analysis of the obtained CAL gains indicated that GTR treatment of deep intrabony defects decreased, with respect to the access flap control, the probability of obtaining only a modest attachment gain at 1 year. Conversely, CAL gains of 4 mm or more were.en_US
dc.languageengen_US
dc.publisherAmerican Academy of Periodontology. The Journal's web site is located at http://www.perio.orgen_US
dc.relation.ispartofJournal of Periodontologyen_US
dc.subject.meshAbsorbable Implantsen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshAlveolar Bone Loss - Surgeryen_US
dc.subject.meshBiocompatible Materials - Therapeutic Useen_US
dc.subject.meshFemaleen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshGuided Tissue Regeneration, Periodontalen_US
dc.subject.meshHumansen_US
dc.subject.meshLactic Acid - Therapeutic Useen_US
dc.subject.meshMaleen_US
dc.subject.meshMembranes, Artificialen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshOutcome Assessment (Health Care)en_US
dc.subject.meshPeriodontal Attachment Loss - Surgeryen_US
dc.subject.meshPeriodontal Pocket - Surgeryen_US
dc.subject.meshPolyglycolic Acid - Therapeutic Useen_US
dc.subject.meshPolymers - Therapeutic Useen_US
dc.subject.meshReproducibility Of Resultsen_US
dc.subject.meshSurgical Flapsen_US
dc.titleGeneralizability of the Added Benefits of Guided Tissue Regeneration in the Treatment of Deep Intrabony Defects. Evaluation in a Multi-Center Randomized Controlled Clinical Trialen_US
dc.typeArticleen_US
dc.identifier.emailLang, NP:nplang@hkucc.hku.hken_US
dc.identifier.authorityLang, NP=rp00031en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid9848527-
dc.identifier.scopuseid_2-s2.0-0032200616en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032200616&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume69en_US
dc.identifier.issue11en_US
dc.identifier.spage1183en_US
dc.identifier.epage1192en_US
dc.identifier.isiWOS:000077280200001-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridTonetti, MS=35602248900en_US
dc.identifier.scopusauthoridCortellini, P=7004422576en_US
dc.identifier.scopusauthoridSuvan, JE=19637686000en_US
dc.identifier.scopusauthoridAdriaens, P=7007006026en_US
dc.identifier.scopusauthoridBaldi, C=7003429150en_US
dc.identifier.scopusauthoridDubravec, D=36963026500en_US
dc.identifier.scopusauthoridFonzar, A=6506961336en_US
dc.identifier.scopusauthoridFourmousis, I=6602718088en_US
dc.identifier.scopusauthoridMagnani, C=7005391103en_US
dc.identifier.scopusauthoridMullerCampanile, V=9635646300en_US
dc.identifier.scopusauthoridPatroni, S=6506502007en_US
dc.identifier.scopusauthoridSanz, M=7201640876en_US
dc.identifier.scopusauthoridVangsted, T=6508378968en_US
dc.identifier.scopusauthoridZabalegui, I=6603283943en_US
dc.identifier.scopusauthoridPrato, GP=7006360589en_US
dc.identifier.scopusauthoridLang, NP=7201577367en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats