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Article: Neutrophil Migration into the Gingival Sulcus Is Associated with Transepithelial Gradients of Interleukin-8 and ICAM-1

TitleNeutrophil Migration into the Gingival Sulcus Is Associated with Transepithelial Gradients of Interleukin-8 and ICAM-1
Authors
Issue Date1998
PublisherAmerican Academy of Periodontology. The Journal's web site is located at http://www.perio.org
Citation
Journal Of Periodontology, 1998, v. 69 n. 10, p. 1139-1147 How to Cite?
AbstractTHE EXPRESSION OF ADHESION MOLECULES and the local production of chemotactic cytokines within the epithelium are considered to be key events in neutrophil (PMN) migration at sites of mucosal infections. In their journey toward the gingival sulcus, PMNs have been shown to selectively migrate through the junctional epithelium. Little, however, is known about the molecular mechanisms involved in this key process aimed at the control of subgingival bacterial plaque. This investigation describes the expression of IL-8 mRNA-positive cells and the establishment of a gradient of inter-cellular adhesion molecule-1 (ICAM-1) receptors within the junctional epithelium of clinically healthy gingiva. Expression of ICAM-1 and IL-8 was topographically associated with the area of PMN migration; i.e., the junctional epithelium. Levels of ICAM-1 expression increased from the basal cells toward the surface of the junctional epithelium and thus toward areas exposed to bacterial challenges. IL-8 mRNA-positive cells were also present at highest density in the most superficial junctional epithelial layers. The combination of the haptotactic stimuli, resulting from the interaction of the PMN's β2 integrin receptors with the gradient of ICAM-1 expression, and the location of IL-8 mRNA-positive cells, consistent with the establishment of a discrete PMN chemotactic source, may play an important physiologic role in efficiently routing PMNs to the gingival sulcus. This process contributes to the maintenance of a local host-parasite equilibrium and to the limitation of PMN-associated tissue damage.
Persistent Identifierhttp://hdl.handle.net/10722/154037
ISSN
2015 Impact Factor: 2.844
2015 SCImago Journal Rankings: 1.070
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTonertti, MSen_US
dc.contributor.authorImboden, MAen_US
dc.contributor.authorLang, NPen_US
dc.date.accessioned2012-08-08T08:22:55Z-
dc.date.available2012-08-08T08:22:55Z-
dc.date.issued1998en_US
dc.identifier.citationJournal Of Periodontology, 1998, v. 69 n. 10, p. 1139-1147en_US
dc.identifier.issn0022-3492en_US
dc.identifier.urihttp://hdl.handle.net/10722/154037-
dc.description.abstractTHE EXPRESSION OF ADHESION MOLECULES and the local production of chemotactic cytokines within the epithelium are considered to be key events in neutrophil (PMN) migration at sites of mucosal infections. In their journey toward the gingival sulcus, PMNs have been shown to selectively migrate through the junctional epithelium. Little, however, is known about the molecular mechanisms involved in this key process aimed at the control of subgingival bacterial plaque. This investigation describes the expression of IL-8 mRNA-positive cells and the establishment of a gradient of inter-cellular adhesion molecule-1 (ICAM-1) receptors within the junctional epithelium of clinically healthy gingiva. Expression of ICAM-1 and IL-8 was topographically associated with the area of PMN migration; i.e., the junctional epithelium. Levels of ICAM-1 expression increased from the basal cells toward the surface of the junctional epithelium and thus toward areas exposed to bacterial challenges. IL-8 mRNA-positive cells were also present at highest density in the most superficial junctional epithelial layers. The combination of the haptotactic stimuli, resulting from the interaction of the PMN's β2 integrin receptors with the gradient of ICAM-1 expression, and the location of IL-8 mRNA-positive cells, consistent with the establishment of a discrete PMN chemotactic source, may play an important physiologic role in efficiently routing PMNs to the gingival sulcus. This process contributes to the maintenance of a local host-parasite equilibrium and to the limitation of PMN-associated tissue damage.en_US
dc.languageengen_US
dc.publisherAmerican Academy of Periodontology. The Journal's web site is located at http://www.perio.orgen_US
dc.relation.ispartofJournal of Periodontologyen_US
dc.subject.meshAntigens, Cd18 - Immunologyen_US
dc.subject.meshCell Movementen_US
dc.subject.meshCells, Cultureden_US
dc.subject.meshChemotaxis, Leukocyteen_US
dc.subject.meshColoring Agents - Diagnostic Useen_US
dc.subject.meshConnective Tissue - Immunology - Pathologyen_US
dc.subject.meshDental Plaque - Microbiology - Prevention & Controlen_US
dc.subject.meshE-Selectin - Analysis - Immunologyen_US
dc.subject.meshEpithelial Attachment - Immunology - Pathologyen_US
dc.subject.meshEpithelium - Immunology - Pathologyen_US
dc.subject.meshGene Expression Regulationen_US
dc.subject.meshGingiva - Immunology - Pathologyen_US
dc.subject.meshHaptens - Immunologyen_US
dc.subject.meshHumansen_US
dc.subject.meshIntercellular Adhesion Molecule-1 - Analysis - Immunologyen_US
dc.subject.meshInterleukin-8 - Analysis - Genetics - Immunologyen_US
dc.subject.meshLeukocyte Counten_US
dc.subject.meshNeutrophils - Immunology - Pathologyen_US
dc.subject.meshRna, Messenger - Geneticsen_US
dc.subject.meshReceptors, Leukocyte-Adhesion - Immunologyen_US
dc.titleNeutrophil Migration into the Gingival Sulcus Is Associated with Transepithelial Gradients of Interleukin-8 and ICAM-1en_US
dc.typeArticleen_US
dc.identifier.emailLang, NP:nplang@hkucc.hku.hken_US
dc.identifier.authorityLang, NP=rp00031en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid9802714-
dc.identifier.scopuseid_2-s2.0-0032175358en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032175358&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume69en_US
dc.identifier.issue10en_US
dc.identifier.spage1139en_US
dc.identifier.epage1147en_US
dc.identifier.isiWOS:000076518000010-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridTonertti, MS=7801559861en_US
dc.identifier.scopusauthoridImboden, MA=9044173700en_US
dc.identifier.scopusauthoridLang, NP=7201577367en_US

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