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Article: The effect of a deproteinized bovine bone mineral on bone regeneration around titanium dental implants

TitleThe effect of a deproteinized bovine bone mineral on bone regeneration around titanium dental implants
Authors
Issue Date1998
PublisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CLR
Citation
Clinical Oral Implants Research, 1998, v. 9 n. 3, p. 151-162 How to Cite?
AbstractThe aim of the present experiment was to test the effect of a deproteinized bovine bone mineral (Bio-Oss®) on guided bone regeneration (GBR) in dehiscence defects around implants. The first 2 molars and all premolars were extracted on both sides of the mandibles of 3 monkeys (Macaca fascicularis). Three months later, 2 titanium plasma-coated cylindrical implants were placed in all quadrants of each monkey. During the surgical procedure, standardized dehiscence defects were produced buccally and lingually, mea suring 2.5 mm in width and 3 mm in height. Four different experimental situations were created: 2 sites in each monkey were covered with an ePTFE membrane (M), 2 were filled with the graft material (DBBM), 2 were filled with the graft material and also covered with a membrane (M+DBBM), and 2 control sites were neither grafted nor covered (C). The flaps were sutured to allow for primary healing. Linear measurements of bone height and width were calculated on histological specimens obtained 6 months following surgery. In addition, values for bone density and for surface fraction of graft to new bone contact were measured. Vertical bone growth along the implant surface of 100% (SD 0%) for M+DBBM, 91% (SD 9%) for M, 52% (SD 24%) for DBBM, and 42% (SD 35%) for C was measured. The width of the regenerated bone 1.5 mm above the bottom of the original defect, i.e. at the 50% mark of the vertical extension of the defect, in relation to the width at the bottom of the defect amounted to 97% (SD 2%) for M+DBBM, 85% (SD 9%) for M, 42% (SD 41%) for DBBM, and 23% (SD 31%) for C. Assessment of bone density within the confinement of the regenerated bone resulted in an increase of 30% (SD 11%) for M+DBBM, 45% (SD 20%) for M, 33% (SD 20%) for DBBM, and 22% (SD 23%) for C. The values for graft to new bone contact within this compartment amounted to 80% (SD 15%) for M+DBBM and 89% (SD 14%) for DBBM. In conclusion, BioOss® exhibited osteoconductive properties and hence can be recommended for GBR procedures in dehiscence defects with respect to vertical and horizontal growth of bone. © Munksgaard 1998.
Persistent Identifierhttp://hdl.handle.net/10722/154026
ISSN
2015 Impact Factor: 3.464
2015 SCImago Journal Rankings: 1.427
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHämmerle, CHFen_US
dc.contributor.authorChiantella, GCen_US
dc.contributor.authorKarring, Ten_US
dc.contributor.authorLang, NPen_US
dc.date.accessioned2012-08-08T08:22:52Z-
dc.date.available2012-08-08T08:22:52Z-
dc.date.issued1998en_US
dc.identifier.citationClinical Oral Implants Research, 1998, v. 9 n. 3, p. 151-162en_US
dc.identifier.issn0905-7161en_US
dc.identifier.urihttp://hdl.handle.net/10722/154026-
dc.description.abstractThe aim of the present experiment was to test the effect of a deproteinized bovine bone mineral (Bio-Oss®) on guided bone regeneration (GBR) in dehiscence defects around implants. The first 2 molars and all premolars were extracted on both sides of the mandibles of 3 monkeys (Macaca fascicularis). Three months later, 2 titanium plasma-coated cylindrical implants were placed in all quadrants of each monkey. During the surgical procedure, standardized dehiscence defects were produced buccally and lingually, mea suring 2.5 mm in width and 3 mm in height. Four different experimental situations were created: 2 sites in each monkey were covered with an ePTFE membrane (M), 2 were filled with the graft material (DBBM), 2 were filled with the graft material and also covered with a membrane (M+DBBM), and 2 control sites were neither grafted nor covered (C). The flaps were sutured to allow for primary healing. Linear measurements of bone height and width were calculated on histological specimens obtained 6 months following surgery. In addition, values for bone density and for surface fraction of graft to new bone contact were measured. Vertical bone growth along the implant surface of 100% (SD 0%) for M+DBBM, 91% (SD 9%) for M, 52% (SD 24%) for DBBM, and 42% (SD 35%) for C was measured. The width of the regenerated bone 1.5 mm above the bottom of the original defect, i.e. at the 50% mark of the vertical extension of the defect, in relation to the width at the bottom of the defect amounted to 97% (SD 2%) for M+DBBM, 85% (SD 9%) for M, 42% (SD 41%) for DBBM, and 23% (SD 31%) for C. Assessment of bone density within the confinement of the regenerated bone resulted in an increase of 30% (SD 11%) for M+DBBM, 45% (SD 20%) for M, 33% (SD 20%) for DBBM, and 22% (SD 23%) for C. The values for graft to new bone contact within this compartment amounted to 80% (SD 15%) for M+DBBM and 89% (SD 14%) for DBBM. In conclusion, BioOss® exhibited osteoconductive properties and hence can be recommended for GBR procedures in dehiscence defects with respect to vertical and horizontal growth of bone. © Munksgaard 1998.en_US
dc.languageengen_US
dc.publisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CLRen_US
dc.relation.ispartofClinical Oral Implants Researchen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBone Densityen_US
dc.subject.meshBone Regenerationen_US
dc.subject.meshBone Substitutesen_US
dc.subject.meshBone Transplantation - Methodsen_US
dc.subject.meshCattleen_US
dc.subject.meshDental Implantation, Endosseousen_US
dc.subject.meshDental Implantsen_US
dc.subject.meshGuided Tissue Regeneration, Periodontal - Methodsen_US
dc.subject.meshMacaca Fascicularisen_US
dc.subject.meshMandible - Pathology - Physiology - Surgeryen_US
dc.subject.meshMembranes, Artificialen_US
dc.subject.meshMineralsen_US
dc.subject.meshOsseointegrationen_US
dc.subject.meshPolytetrafluoroethyleneen_US
dc.subject.meshTitaniumen_US
dc.subject.meshTooth Socketen_US
dc.titleThe effect of a deproteinized bovine bone mineral on bone regeneration around titanium dental implantsen_US
dc.typeArticleen_US
dc.identifier.emailLang, NP:nplang@hkucc.hku.hken_US
dc.identifier.authorityLang, NP=rp00031en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid10530129-
dc.identifier.scopuseid_2-s2.0-0032082608en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032082608&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume9en_US
dc.identifier.issue3en_US
dc.identifier.spage151en_US
dc.identifier.epage162en_US
dc.identifier.isiWOS:000074240400002-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridHämmerle, CHF=7005331848en_US
dc.identifier.scopusauthoridChiantella, GC=6602325272en_US
dc.identifier.scopusauthoridKarring, T=35560651200en_US
dc.identifier.scopusauthoridLang, NP=7201577367en_US

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