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Article: The relationship between the cell length, adhesion to acrylic and relative cell surface hydrophobicity of Candida parapsilosis

TitleThe relationship between the cell length, adhesion to acrylic and relative cell surface hydrophobicity of Candida parapsilosis
Authors
Issue Date1998
PublisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/13693786.asp
Citation
Medical Mycology, 1998, v. 36 n. 6, p. 373-378 How to Cite?
AbstractCandida parapsilosis is an emerging opportunistic pathogen which causes systemic and superficial infections in immunocompromised hosts. Successful colonization and subsequent infection of the host by a microorganism depends upon its ability to adhere to host surfaces, and its relative cell surface hydrophobicity (CSH) is a contributory physical force involved in the process. During a comprehensive study of a battery of C. parapsilosis isolates, we noted wide variations in their cell size. Hence we examined the relationship between the cell length, in vitro adhesion to acrylic surfaces and relative CSH of 24 isolates of C. parapsilosis from superficial and systemic sources. A strong positive correlation was observed between the cell length and adhesion of Candida to acrylic surfaces (r = 0.56; P = 0.004) as well as the cell length and the relative CSH, as measured by a hydrocarbon assay method (r = 0.72, P = 0.0001). Further, the cell length of both the superficial and systemic isolates correlated well with their CSH (r = 0.63, P = 0.01; r = 0.63, P = 0.03 for superficial and systemic isolates, respectively). These data provide a tantalizing glimpse of the structural and functional dynamics of the candidal cell surface.
Persistent Identifierhttp://hdl.handle.net/10722/154017
ISSN
2015 Impact Factor: 2.644
2015 SCImago Journal Rankings: 1.055
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorPanagoda, GJen_US
dc.contributor.authorSamaranayake, LPen_US
dc.date.accessioned2012-08-08T08:22:49Z-
dc.date.available2012-08-08T08:22:49Z-
dc.date.issued1998en_US
dc.identifier.citationMedical Mycology, 1998, v. 36 n. 6, p. 373-378en_US
dc.identifier.issn1369-3786en_US
dc.identifier.urihttp://hdl.handle.net/10722/154017-
dc.description.abstractCandida parapsilosis is an emerging opportunistic pathogen which causes systemic and superficial infections in immunocompromised hosts. Successful colonization and subsequent infection of the host by a microorganism depends upon its ability to adhere to host surfaces, and its relative cell surface hydrophobicity (CSH) is a contributory physical force involved in the process. During a comprehensive study of a battery of C. parapsilosis isolates, we noted wide variations in their cell size. Hence we examined the relationship between the cell length, in vitro adhesion to acrylic surfaces and relative CSH of 24 isolates of C. parapsilosis from superficial and systemic sources. A strong positive correlation was observed between the cell length and adhesion of Candida to acrylic surfaces (r = 0.56; P = 0.004) as well as the cell length and the relative CSH, as measured by a hydrocarbon assay method (r = 0.72, P = 0.0001). Further, the cell length of both the superficial and systemic isolates correlated well with their CSH (r = 0.63, P = 0.01; r = 0.63, P = 0.03 for superficial and systemic isolates, respectively). These data provide a tantalizing glimpse of the structural and functional dynamics of the candidal cell surface.en_US
dc.languageengen_US
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/13693786.aspen_US
dc.relation.ispartofMedical Mycologyen_US
dc.subject.meshAcrylic Resinsen_US
dc.subject.meshCandida - Cytology - Isolation & Purification - Physiologyen_US
dc.subject.meshCandidiasis - Microbiologyen_US
dc.subject.meshCell Adhesionen_US
dc.subject.meshDenturesen_US
dc.subject.meshDermatomycoses - Microbiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshMicroscopy, Electron, Scanningen_US
dc.subject.meshMouth - Microbiologyen_US
dc.subject.meshSepsis - Microbiologyen_US
dc.subject.meshSurface Propertiesen_US
dc.titleThe relationship between the cell length, adhesion to acrylic and relative cell surface hydrophobicity of Candida parapsilosisen_US
dc.typeArticleen_US
dc.identifier.emailSamaranayake, LP:lakshman@hku.hken_US
dc.identifier.authoritySamaranayake, LP=rp00023en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1080/02681219880000591-
dc.identifier.pmid10206746-
dc.identifier.scopuseid_2-s2.0-0031745544en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031745544&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume36en_US
dc.identifier.issue6en_US
dc.identifier.spage373en_US
dc.identifier.epage378en_US
dc.identifier.isiWOS:000077858400003-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridPanagoda, GJ=6507149433en_US
dc.identifier.scopusauthoridSamaranayake, LP=7102761002en_US

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