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Article: Vascular endothelial growth pattern during demineralized bone matrix induced osteogenesis

TitleVascular endothelial growth pattern during demineralized bone matrix induced osteogenesis
Authors
KeywordsAngiogenesis
Bone induction
CD31-antigen
Demineralized bone matrix
Factor-VIII
Ultrastructure
Issue Date1997
PublisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/03008207.asp
Citation
Connective Tissue Research, 1997, v. 36 n. 4, p. 337-345 How to Cite?
AbstractThe purpose of the current study was to determine the timely ingrowth of blood vessels associated with demineralized bone matrix (DMB) induced osteogenesis. Critical-size (10 x 5mm), full thickness bony defects in rabbit parietal bone were implanted with DBM. Histological and ultrastructural changes were examined 1, 2, 3, 4, 5, 6, 7 and 14 days later. Neovascularization was assessed by immunohistochemical staining for factor VIII antigen (marker for vascular endothelium) and also confirmed by staining using pan-endothelial antibody (CD31) (a marker for endothelium). Immunohistochemical evaluation revealed a positive staining for CD31 and Factor VIII expressed by endothelial cells by day 3 post grafting. By day 4, small blood vessels were first seen budding from host bed towards the grafted DBM. Ultrastructural identification of cells in the early stages of healing revealed the presence of macrophages. The monocyte-derived macrophage appears to play a central role in the repair process using DBM. Results of this study demonstrated a rapid vascularization during the DBM induced osteogenesis. This rapid vascularization is vital to the healing and bone induction ability of the DBM.
Persistent Identifierhttp://hdl.handle.net/10722/154014
ISSN
2015 Impact Factor: 1.411
2015 SCImago Journal Rankings: 0.622
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorRabie, ABMen_HK
dc.date.accessioned2012-08-08T08:22:49Z-
dc.date.available2012-08-08T08:22:49Z-
dc.date.issued1997en_HK
dc.identifier.citationConnective Tissue Research, 1997, v. 36 n. 4, p. 337-345en_HK
dc.identifier.issn0300-8207en_HK
dc.identifier.urihttp://hdl.handle.net/10722/154014-
dc.description.abstractThe purpose of the current study was to determine the timely ingrowth of blood vessels associated with demineralized bone matrix (DMB) induced osteogenesis. Critical-size (10 x 5mm), full thickness bony defects in rabbit parietal bone were implanted with DBM. Histological and ultrastructural changes were examined 1, 2, 3, 4, 5, 6, 7 and 14 days later. Neovascularization was assessed by immunohistochemical staining for factor VIII antigen (marker for vascular endothelium) and also confirmed by staining using pan-endothelial antibody (CD31) (a marker for endothelium). Immunohistochemical evaluation revealed a positive staining for CD31 and Factor VIII expressed by endothelial cells by day 3 post grafting. By day 4, small blood vessels were first seen budding from host bed towards the grafted DBM. Ultrastructural identification of cells in the early stages of healing revealed the presence of macrophages. The monocyte-derived macrophage appears to play a central role in the repair process using DBM. Results of this study demonstrated a rapid vascularization during the DBM induced osteogenesis. This rapid vascularization is vital to the healing and bone induction ability of the DBM.en_HK
dc.languageengen_US
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/03008207.aspen_HK
dc.relation.ispartofConnective Tissue Researchen_HK
dc.subjectAngiogenesisen_HK
dc.subjectBone inductionen_HK
dc.subjectCD31-antigenen_HK
dc.subjectDemineralized bone matrixen_HK
dc.subjectFactor-VIIIen_HK
dc.subjectUltrastructureen_HK
dc.subject.meshAnimalsen_US
dc.subject.meshAntigens, Cd31 - Analysis - Physiologyen_US
dc.subject.meshBone Matrix - Physiologyen_US
dc.subject.meshEndothelium, Vascular - Cytology - Growth & Developmenten_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshImplants, Experimentalen_US
dc.subject.meshMacrophages - Physiology - Ultrastructureen_US
dc.subject.meshOsteogenesis - Drug Effectsen_US
dc.subject.meshParietal Bone - Blood Supply - Cytology - Drug Effectsen_US
dc.subject.meshRabbitsen_US
dc.titleVascular endothelial growth pattern during demineralized bone matrix induced osteogenesisen_HK
dc.typeArticleen_HK
dc.identifier.emailRabie, ABM: rabie@hku.hken_HK
dc.identifier.authorityRabie, ABM=rp00029en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid9610891-
dc.identifier.scopuseid_2-s2.0-0031421525en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031421525&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume36en_HK
dc.identifier.issue4en_HK
dc.identifier.spage337en_HK
dc.identifier.epage345en_HK
dc.identifier.isiWOS:000073087300005-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridRabie, ABM=7007172734en_HK

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