File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Effect of the NSAID flurbiprofen on remodelling after periodontal surgery

TitleEffect of the NSAID flurbiprofen on remodelling after periodontal surgery
Authors
Issue Date1997
PublisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0022-3484&site=1
Citation
Journal Of Periodontal Research, 1997, v. 32 n. 7, p. 575-582 How to Cite?
AbstractThe aim of the present experiment was to assess the effect of the administration of the NSAID flurbiprofen (Froben®) on tissue healing after periodontal surgery. Sites from patients with the same treatment modality (modified Widman flap) but receiving a placebo drug and sites within each patient not exposed to surgery served as controls. Nineteen patients suffering from moderate to severe periodontal disease were recruited and they signed informed consent forms. These patients required periodontal surgery as assessed at the periodontal re-evaluation. The sites chosen for the study were all diagnosed with PPD ≥ 5 mm and were bleeding on probing. During the healing phase 10 patients received 50 mg Froben® 3 times per day for 30 d whereas 9 patients received a placebo drug. Two sites with PPD ≥ 5 mm after initial therapy and bleeding on probing served as surgical sites, whereas 2 similar sites were not exposed to surgery. The study design was set up double-blind. The radiographic examination consisted of 2-4 standardized vertical bitewings obtained at the periodontal re-evaluation (BL) at 1, 3 and 6 months postsurgically for digital subtraction and computer assisted densitometric image analysis (CADIA). The regions of interest analysed were mesial or distal crestal sites. Minimal remodelling activity was observed radiographically after periodontal surgery in both patient groups. There were no statistically significant differences between the four groups of sites regarding the mean changes in density when analysing the pairs of radiographs 0-1, 0-3, 0-6 months. A frequency analysis was performed to list the number of sites with different ranges of density change. No differences in the distributions of the numbers of sites were observed when comparing the 4 site groups (Kolmogorov-Smirnov, p> 0.05). A significant reduction of the probing pocket depth and a significant amount of clinical attachment gain was noted at the surgically treated sites irrespective of whether the patients had used flurbiprofen or placebo. Whereas the pathways leading to bone resorption in periodontally diseased sites have been shown, in other studies, to be influenced by NSAID, the results of the present study could not justify general administration of Froben® for the purpose of reduction of bone resorption after periodontal surgical procedures in patients with adult periodontitis. © Munksgaard, 1997.
Persistent Identifierhttp://hdl.handle.net/10722/154004
ISSN
2015 Impact Factor: 2.474
2015 SCImago Journal Rankings: 0.932
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorBrägger, Uen_US
dc.contributor.authorMühle, Ten_US
dc.contributor.authorFourmousis, Ien_US
dc.contributor.authorLang, NPen_US
dc.contributor.authorMombelli, Aen_US
dc.date.accessioned2012-08-08T08:22:46Z-
dc.date.available2012-08-08T08:22:46Z-
dc.date.issued1997en_US
dc.identifier.citationJournal Of Periodontal Research, 1997, v. 32 n. 7, p. 575-582en_US
dc.identifier.issn0022-3484en_US
dc.identifier.urihttp://hdl.handle.net/10722/154004-
dc.description.abstractThe aim of the present experiment was to assess the effect of the administration of the NSAID flurbiprofen (Froben®) on tissue healing after periodontal surgery. Sites from patients with the same treatment modality (modified Widman flap) but receiving a placebo drug and sites within each patient not exposed to surgery served as controls. Nineteen patients suffering from moderate to severe periodontal disease were recruited and they signed informed consent forms. These patients required periodontal surgery as assessed at the periodontal re-evaluation. The sites chosen for the study were all diagnosed with PPD ≥ 5 mm and were bleeding on probing. During the healing phase 10 patients received 50 mg Froben® 3 times per day for 30 d whereas 9 patients received a placebo drug. Two sites with PPD ≥ 5 mm after initial therapy and bleeding on probing served as surgical sites, whereas 2 similar sites were not exposed to surgery. The study design was set up double-blind. The radiographic examination consisted of 2-4 standardized vertical bitewings obtained at the periodontal re-evaluation (BL) at 1, 3 and 6 months postsurgically for digital subtraction and computer assisted densitometric image analysis (CADIA). The regions of interest analysed were mesial or distal crestal sites. Minimal remodelling activity was observed radiographically after periodontal surgery in both patient groups. There were no statistically significant differences between the four groups of sites regarding the mean changes in density when analysing the pairs of radiographs 0-1, 0-3, 0-6 months. A frequency analysis was performed to list the number of sites with different ranges of density change. No differences in the distributions of the numbers of sites were observed when comparing the 4 site groups (Kolmogorov-Smirnov, p> 0.05). A significant reduction of the probing pocket depth and a significant amount of clinical attachment gain was noted at the surgically treated sites irrespective of whether the patients had used flurbiprofen or placebo. Whereas the pathways leading to bone resorption in periodontally diseased sites have been shown, in other studies, to be influenced by NSAID, the results of the present study could not justify general administration of Froben® for the purpose of reduction of bone resorption after periodontal surgical procedures in patients with adult periodontitis. © Munksgaard, 1997.en_US
dc.languageengen_US
dc.publisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0022-3484&site=1en_US
dc.relation.ispartofJournal of Periodontal Researchen_US
dc.subject.meshAbsorptiometry, Photonen_US
dc.subject.meshAdulten_US
dc.subject.meshAlveolar Bone Loss - Radiography - Surgeryen_US
dc.subject.meshAlveolar Process - Drug Effects - Radiographyen_US
dc.subject.meshAnti-Inflammatory Agents, Non-Steroidal - Administration & Dosage - Therapeutic Useen_US
dc.subject.meshBone Remodeling - Drug Effectsen_US
dc.subject.meshDouble-Blind Methoden_US
dc.subject.meshFlurbiprofen - Administration & Dosage - Therapeutic Useen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshGingival Hemorrhage - Surgeryen_US
dc.subject.meshHumansen_US
dc.subject.meshImage Processing, Computer-Assisteden_US
dc.subject.meshPeriodontal Attachment Loss - Radiography - Surgeryen_US
dc.subject.meshPeriodontal Pocket - Radiography - Surgeryen_US
dc.subject.meshPeriodontitis - Radiography - Surgeryen_US
dc.subject.meshPeriodontium - Drug Effects - Radiographyen_US
dc.subject.meshPlacebosen_US
dc.subject.meshRadiography, Bitewingen_US
dc.subject.meshSubtraction Techniqueen_US
dc.subject.meshSurgical Flapsen_US
dc.subject.meshWound Healingen_US
dc.titleEffect of the NSAID flurbiprofen on remodelling after periodontal surgeryen_US
dc.typeArticleen_US
dc.identifier.emailLang, NP:nplang@hkucc.hku.hken_US
dc.identifier.authorityLang, NP=rp00031en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid9401929-
dc.identifier.scopuseid_2-s2.0-0031243480en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031243480&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume32en_US
dc.identifier.issue7en_US
dc.identifier.spage575en_US
dc.identifier.epage582en_US
dc.identifier.isiWOS:A1997YD32700003-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridBrägger, U=7005538598en_US
dc.identifier.scopusauthoridMühle, T=6506132829en_US
dc.identifier.scopusauthoridFourmousis, I=6602718088en_US
dc.identifier.scopusauthoridLang, NP=7201577367en_US
dc.identifier.scopusauthoridMombelli, A=7006180872en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats