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Article: Miconazole lacquer in the treatment of denture stomatitis: clinical and microbiological findings in Chinese patients.

TitleMiconazole lacquer in the treatment of denture stomatitis: clinical and microbiological findings in Chinese patients.
Authors
Issue Date1997
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00784/index.htm
Citation
Clinical Oral Investigations, 1997, v. 1 n. 1, p. 47-52 How to Cite?
AbstractOBJECTIVE: To investigate the efficacy of a miconazole lacquer in producing mycological and clinical cure of Candida-associated denture stomatitis in a Chinese cohort and to study the microbiology of the conditions. DESIGN: A cross-sectional study of the clinical and microbiological features of the condition and its response to treatment with the lacquer. SUBJECTS AND METHOD: Twenty-one Chinese adults with palatal erythema; 15 denture wearers matched for age and sex as controls for microbiology. Clinical examination, impression for culture, photograph of palate to monitor response to treatment, and lacquer application on upper denture base on days 0, 7 and 14. Impression and photograph repeated on day 21; impression cultures quantified by image analysis. Palatal impression in controls; dummy impression as control for impression culture procedures. MAIN OUTCOME MEASURES: Severity of lesion, incidence and type of microorganism at presentation and during treatment; qualitative and quantitative assessment of yeast growth; the latter by statistical analysis of pixel units of yeast colonies; correlation of clinical and mycological cure. RESULTS: Out of the 21 lesions (16 Newton's stage I and 5 stage II), 57% had yeasts at presentation, 10% coliforms and 33% no significant growth. Clinical cure in 3 weeks in 71%, mycological cure in 75% in 7 days; clinical and mycological cure coincided only in 43%. Polymicrobial growth of yeasts and coliforms throughout the course in some. CONCLUSIONS: Miconazole lacquer was a viable treatment option for Candida-associated denture stomatitis in this adult, Chinese cohort; microbiology comprised yeasts, mainly C. albicans and coliforms, especially Klebsiella and Enterobacter species; the pathogenic role of the latter is questionable.
Persistent Identifierhttp://hdl.handle.net/10722/153989
ISSN
2015 Impact Factor: 2.207
2015 SCImago Journal Rankings: 0.752

 

DC FieldValueLanguage
dc.contributor.authorDias, APen_US
dc.contributor.authorSamaranayake, LPen_US
dc.contributor.authorLee, MTen_US
dc.date.accessioned2012-08-08T08:22:41Z-
dc.date.available2012-08-08T08:22:41Z-
dc.date.issued1997en_US
dc.identifier.citationClinical Oral Investigations, 1997, v. 1 n. 1, p. 47-52en_US
dc.identifier.issn1432-6981en_US
dc.identifier.urihttp://hdl.handle.net/10722/153989-
dc.description.abstractOBJECTIVE: To investigate the efficacy of a miconazole lacquer in producing mycological and clinical cure of Candida-associated denture stomatitis in a Chinese cohort and to study the microbiology of the conditions. DESIGN: A cross-sectional study of the clinical and microbiological features of the condition and its response to treatment with the lacquer. SUBJECTS AND METHOD: Twenty-one Chinese adults with palatal erythema; 15 denture wearers matched for age and sex as controls for microbiology. Clinical examination, impression for culture, photograph of palate to monitor response to treatment, and lacquer application on upper denture base on days 0, 7 and 14. Impression and photograph repeated on day 21; impression cultures quantified by image analysis. Palatal impression in controls; dummy impression as control for impression culture procedures. MAIN OUTCOME MEASURES: Severity of lesion, incidence and type of microorganism at presentation and during treatment; qualitative and quantitative assessment of yeast growth; the latter by statistical analysis of pixel units of yeast colonies; correlation of clinical and mycological cure. RESULTS: Out of the 21 lesions (16 Newton's stage I and 5 stage II), 57% had yeasts at presentation, 10% coliforms and 33% no significant growth. Clinical cure in 3 weeks in 71%, mycological cure in 75% in 7 days; clinical and mycological cure coincided only in 43%. Polymicrobial growth of yeasts and coliforms throughout the course in some. CONCLUSIONS: Miconazole lacquer was a viable treatment option for Candida-associated denture stomatitis in this adult, Chinese cohort; microbiology comprised yeasts, mainly C. albicans and coliforms, especially Klebsiella and Enterobacter species; the pathogenic role of the latter is questionable.en_US
dc.languageengen_US
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00784/index.htmen_US
dc.relation.ispartofClinical oral investigationsen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshAntifungal Agents - Administration & Dosage - Therapeutic Useen_US
dc.subject.meshCandida - Isolation & Purificationen_US
dc.subject.meshCandidiasis, Oral - Drug Therapy - Microbiologyen_US
dc.subject.meshCross-Sectional Studiesen_US
dc.subject.meshDelayed-Action Preparationsen_US
dc.subject.meshDenture, Complete, Upper - Adverse Effectsen_US
dc.subject.meshDrug Delivery Systemsen_US
dc.subject.meshEnterobacteriaceae - Isolation & Purificationen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshLacqueren_US
dc.subject.meshMaleen_US
dc.subject.meshMiconazole - Administration & Dosage - Therapeutic Useen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshStatistics, Nonparametricen_US
dc.subject.meshStomatitis, Denture - Drug Therapy - Etiology - Microbiologyen_US
dc.titleMiconazole lacquer in the treatment of denture stomatitis: clinical and microbiological findings in Chinese patients.en_US
dc.typeArticleen_US
dc.identifier.emailSamaranayake, LP:lakshman@hku.hken_US
dc.identifier.authoritySamaranayake, LP=rp00023en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s007840050008-
dc.identifier.pmid9552817-
dc.identifier.scopuseid_2-s2.0-0031061453en_US
dc.identifier.hkuros22364-
dc.identifier.volume1en_US
dc.identifier.issue1en_US
dc.identifier.spage47en_US
dc.identifier.epage52en_US
dc.publisher.placeGermanyen_US
dc.identifier.scopusauthoridDias, AP=36898934100en_US
dc.identifier.scopusauthoridSamaranayake, LP=7102761002en_US
dc.identifier.scopusauthoridLee, MT=18836245800en_US

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