File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: A novel model system for the study of experimental guided bone formation in humans

TitleA novel model system for the study of experimental guided bone formation in humans
Authors
Issue Date1996
PublisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CLR
Citation
Clinical Oral Implants Research, 1996, v. 7 n. 1, p. 38-47 How to Cite?
AbstractThe aim of the present experiment was to test a novel model system, designed to obtain human specimens of regenerated and also newly generated jaw bone, for the study of the biological events under a variety of conditions. Following information and disclosure of possible risks associated with a minor oral surgical procedure, 9 systemically healthy subjects (5 men, 4 women, mean age 31.7 years) signed consent forms and volunteered to participate in this study. Hollow test cylinders with an outer diameter of 3.5 mm, an inner diameter of 2.5 mm, and 4 mm in height were used. They were manufactured from commercially pure titanium and exhibited a highly polished inner surface and a titanium plasma sprayed outer rough surface. A mucoperiosteal flap was raised in the retromolar area of the mandible corresponding to standard retained third molar surgery. Following flap reflection a standardized hole was drilled through the cortical bone into the bone marrow using round burs. The congruent test cylinders were firmly placed into the prepared bony bed yielding primary stability. One-and-a-half to 2 mm of the test device were submerged below the level of the surrounding bone, while the remainder surpassed the level of the bone surface. The bone-facing end of the cylinder was left open, while the coronal soft tissue facing end was closed by an ePTFE-membrane. The flap was sutured to obtain primary wound closure. In order to prevent infection, penicillin was prescribed systemically and oral rinses of chlorhexidine were administered. After 2, 7, and 12 weeks one test device including the regenerated tissue was surgically harvested, while after 16, 24 and 36 weeks respectively, 2 devices were harvested and processed for soft or hard tissue histology or histochemistry. The two surgical procedures and the presence of the test cylinders during the time of healing were well tolerated by the volunteers. In all 9 subjects generated tissue could successfully be harvested. The tissue generated after 2 and 7 weeks presented with a cylindrical shape, whereas the specimens harvested at 12 weeks and thereafter resembled the form of an hourglass. Specimens of 12 weeks and less regeneration time were almost entirely comprised of soft tissue, while specimens with regeneration time of 4 months and more were composed of both soft and increasing amounts of mineralized tissue. It is concluded that the presented model system is suitable to study temporal dynamics and tissue physiology of bone regeneration in humans with minimal risk for complications or adverse effects to the volunteers. Copyright © Munksgaard 1996.
Persistent Identifierhttp://hdl.handle.net/10722/153966
ISSN
2015 Impact Factor: 3.464
2015 SCImago Journal Rankings: 1.427
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHämmerle, CHFen_US
dc.contributor.authorSchmid, Jen_US
dc.contributor.authorOlah, AJen_US
dc.contributor.authorLang, NPen_US
dc.date.accessioned2012-08-08T08:22:32Z-
dc.date.available2012-08-08T08:22:32Z-
dc.date.issued1996en_US
dc.identifier.citationClinical Oral Implants Research, 1996, v. 7 n. 1, p. 38-47en_US
dc.identifier.issn0905-7161en_US
dc.identifier.urihttp://hdl.handle.net/10722/153966-
dc.description.abstractThe aim of the present experiment was to test a novel model system, designed to obtain human specimens of regenerated and also newly generated jaw bone, for the study of the biological events under a variety of conditions. Following information and disclosure of possible risks associated with a minor oral surgical procedure, 9 systemically healthy subjects (5 men, 4 women, mean age 31.7 years) signed consent forms and volunteered to participate in this study. Hollow test cylinders with an outer diameter of 3.5 mm, an inner diameter of 2.5 mm, and 4 mm in height were used. They were manufactured from commercially pure titanium and exhibited a highly polished inner surface and a titanium plasma sprayed outer rough surface. A mucoperiosteal flap was raised in the retromolar area of the mandible corresponding to standard retained third molar surgery. Following flap reflection a standardized hole was drilled through the cortical bone into the bone marrow using round burs. The congruent test cylinders were firmly placed into the prepared bony bed yielding primary stability. One-and-a-half to 2 mm of the test device were submerged below the level of the surrounding bone, while the remainder surpassed the level of the bone surface. The bone-facing end of the cylinder was left open, while the coronal soft tissue facing end was closed by an ePTFE-membrane. The flap was sutured to obtain primary wound closure. In order to prevent infection, penicillin was prescribed systemically and oral rinses of chlorhexidine were administered. After 2, 7, and 12 weeks one test device including the regenerated tissue was surgically harvested, while after 16, 24 and 36 weeks respectively, 2 devices were harvested and processed for soft or hard tissue histology or histochemistry. The two surgical procedures and the presence of the test cylinders during the time of healing were well tolerated by the volunteers. In all 9 subjects generated tissue could successfully be harvested. The tissue generated after 2 and 7 weeks presented with a cylindrical shape, whereas the specimens harvested at 12 weeks and thereafter resembled the form of an hourglass. Specimens of 12 weeks and less regeneration time were almost entirely comprised of soft tissue, while specimens with regeneration time of 4 months and more were composed of both soft and increasing amounts of mineralized tissue. It is concluded that the presented model system is suitable to study temporal dynamics and tissue physiology of bone regeneration in humans with minimal risk for complications or adverse effects to the volunteers. Copyright © Munksgaard 1996.en_US
dc.languageengen_US
dc.publisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CLRen_US
dc.relation.ispartofClinical Oral Implants Researchen_US
dc.subject.meshAdulten_US
dc.subject.meshAlveolar Process - Physiologyen_US
dc.subject.meshBone Regeneration - Physiologyen_US
dc.subject.meshDental Research - Methodsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGuided Tissue Regeneration, Periodontalen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMandible - Physiology - Surgeryen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPeriodontium - Physiologyen_US
dc.subject.meshProstheses And Implantsen_US
dc.subject.meshTime Factorsen_US
dc.subject.meshWound Healingen_US
dc.titleA novel model system for the study of experimental guided bone formation in humansen_US
dc.typeArticleen_US
dc.identifier.emailLang, NP:nplang@hkucc.hku.hken_US
dc.identifier.authorityLang, NP=rp00031en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid9002821en_US
dc.identifier.scopuseid_2-s2.0-0030090765en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030090765&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume7en_US
dc.identifier.issue1en_US
dc.identifier.spage38en_US
dc.identifier.epage47en_US
dc.identifier.isiWOS:A1996UD10400005-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridHämmerle, CHF=7005331848en_US
dc.identifier.scopusauthoridSchmid, J=8419181200en_US
dc.identifier.scopusauthoridOlah, AJ=7006654753en_US
dc.identifier.scopusauthoridLang, NP=7201577367en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats