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Article: Compartmentalization of inflammatory cell phenotypes in normal gingiva and peri-implant keratinized mucosa.

TitleCompartmentalization of inflammatory cell phenotypes in normal gingiva and peri-implant keratinized mucosa.
Authors
Issue Date1995
PublisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CPE
Citation
Journal Of Clinical Periodontology, 1995, v. 22 n. 10, p. 735-742 How to Cite?
AbstractThe interpretation of studies aimed at understanding the pathophysiology of periodontal breakdown has been hampered by an insufficient understanding of the physiology of host responses in clinically healthy gingiva. This investigation was aimed at the evaluation of the in situ phenotype and topographic distribution of the inflammatory cells in clinically normal gingiva and peri-implant keratinized mucosa (PIKM). Soft tissue biopsies were obtained from clinically healthy gingiva or PIKM in 14 patients. Acetone fixed, cryostat sections were stained with a panel of monoclonal antibodies with a three stage avidin-biotin immunoperoxidase technique. Numbers of positive cells/mm2 were determined with a calibrated image analysis system. The major findings of the study were: (i) the presence of significantly higher densities of phenotypically characterized mononuclear cells in the ICT than in the JE in both gingiva and PIKM; (ii) the absence of a significant difference in PMN densities between JE and ICT in both gingiva and PIKM; (iii) the absence of statistically significant differences in densities of phenotypically characterized leukocytes associated with gingiva and PIKM; (iv) the presence of regional differences in the relative proportions of immunocompetent cells in both the gingiva and PIKM. It is concluded that inflammatory cells are selectively distributed in gingiva and PIKM. Unique functional compartments could be identified. The observed compartmentalization requires selective regulatory mechanisms.
Persistent Identifierhttp://hdl.handle.net/10722/153945
ISSN
2015 Impact Factor: 3.915
2015 SCImago Journal Rankings: 1.848
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTonetti, MSen_US
dc.contributor.authorImboden, Men_US
dc.contributor.authorGerber, Len_US
dc.contributor.authorLang, NPen_US
dc.date.accessioned2012-08-08T08:22:26Z-
dc.date.available2012-08-08T08:22:26Z-
dc.date.issued1995en_US
dc.identifier.citationJournal Of Clinical Periodontology, 1995, v. 22 n. 10, p. 735-742en_US
dc.identifier.issn0303-6979en_US
dc.identifier.urihttp://hdl.handle.net/10722/153945-
dc.description.abstractThe interpretation of studies aimed at understanding the pathophysiology of periodontal breakdown has been hampered by an insufficient understanding of the physiology of host responses in clinically healthy gingiva. This investigation was aimed at the evaluation of the in situ phenotype and topographic distribution of the inflammatory cells in clinically normal gingiva and peri-implant keratinized mucosa (PIKM). Soft tissue biopsies were obtained from clinically healthy gingiva or PIKM in 14 patients. Acetone fixed, cryostat sections were stained with a panel of monoclonal antibodies with a three stage avidin-biotin immunoperoxidase technique. Numbers of positive cells/mm2 were determined with a calibrated image analysis system. The major findings of the study were: (i) the presence of significantly higher densities of phenotypically characterized mononuclear cells in the ICT than in the JE in both gingiva and PIKM; (ii) the absence of a significant difference in PMN densities between JE and ICT in both gingiva and PIKM; (iii) the absence of statistically significant differences in densities of phenotypically characterized leukocytes associated with gingiva and PIKM; (iv) the presence of regional differences in the relative proportions of immunocompetent cells in both the gingiva and PIKM. It is concluded that inflammatory cells are selectively distributed in gingiva and PIKM. Unique functional compartments could be identified. The observed compartmentalization requires selective regulatory mechanisms.en_US
dc.languageengen_US
dc.publisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CPEen_US
dc.relation.ispartofJournal of clinical periodontologyen_US
dc.subject.meshB-Lymphocytes - Cytologyen_US
dc.subject.meshBiopsyen_US
dc.subject.meshCd4-Cd8 Ratioen_US
dc.subject.meshCd4-Positive T-Lymphocytes - Cytologyen_US
dc.subject.meshCd8-Positive T-Lymphocytes - Cytologyen_US
dc.subject.meshConnective Tissue Cellsen_US
dc.subject.meshDental Implantsen_US
dc.subject.meshEpithelial Cellsen_US
dc.subject.meshGingiva - Cytologyen_US
dc.subject.meshHumansen_US
dc.subject.meshImage Processing, Computer-Assisteden_US
dc.subject.meshImmunoenzyme Techniquesen_US
dc.subject.meshImmunologic Memoryen_US
dc.subject.meshImmunophenotypingen_US
dc.subject.meshKeratinsen_US
dc.subject.meshLeukocyte Counten_US
dc.subject.meshLeukocytes, Mononuclear - Cytologyen_US
dc.subject.meshLymphocyte Counten_US
dc.subject.meshMacrophages - Cytologyen_US
dc.subject.meshMonocytes - Cytologyen_US
dc.subject.meshMouth Mucosa - Cytologyen_US
dc.subject.meshNeutrophils - Cytologyen_US
dc.subject.meshPhenotypeen_US
dc.subject.meshT-Lymphocyte Subsets - Cytologyen_US
dc.subject.meshT-Lymphocytes - Cytologyen_US
dc.titleCompartmentalization of inflammatory cell phenotypes in normal gingiva and peri-implant keratinized mucosa.en_US
dc.typeArticleen_US
dc.identifier.emailLang, NP:nplang@hkucc.hku.hken_US
dc.identifier.authorityLang, NP=rp00031en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid8682919en_US
dc.identifier.scopuseid_2-s2.0-0029384733en_US
dc.identifier.volume22en_US
dc.identifier.issue10en_US
dc.identifier.spage735en_US
dc.identifier.epage742en_US
dc.identifier.isiWOS:A1995RX42900002-
dc.publisher.placeDenmarken_US
dc.identifier.scopusauthoridTonetti, MS=35602248900en_US
dc.identifier.scopusauthoridImboden, M=9044173700en_US
dc.identifier.scopusauthoridGerber, L=7103016821en_US
dc.identifier.scopusauthoridLang, NP=7201577367en_US

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