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Article: Modulation of the anti-Candida activity of apo-lactoferrin by dietary sucrose and tunicamycin in vitro

TitleModulation of the anti-Candida activity of apo-lactoferrin by dietary sucrose and tunicamycin in vitro
Authors
Issue Date1995
PublisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/archoralbio
Citation
Archives Of Oral Biology, 1995, v. 40 n. 6, p. 581-584 How to Cite?
AbstractThe sensitivity to apo-lactoferrin (apo-LF) of two oral isolates each of Candida albicans and C. krusei preincubated in either sucrose- or tunicamycin-supplemented media was investigated. Known apo-LF-sensitive isolates of both C. albicans and C. krusei demonstrated significantly increased resistance to apo-LF when preincubated in sucrose-supplemented media, but such preincubation had no effect on an apo-LF-resistant isolate of C. albicans, irrespective of the sugar concentration in the medium. Surprisingly, an apo-LF-resistant isolate of C. krusei demonstrated increased susceptibility to apo-LF when preincubated in sucrose. Further, when preincubated with tunicamycin, a chemical that interferes with candidal cell-wall formation, the susceptibility to apo-LF of the resistant isolates increased significantly. These results, when extrapolated in vivo, imply that dietary sucrose may diminish the anticandidal potency of salivary lactoferrin. However, the aberrant behaviour of a single isolate of C. krusei under these circumstances is possibly due to the different cell-wall structure of this yeast and needs to be further investigated.
Persistent Identifierhttp://hdl.handle.net/10722/153931
ISSN
2015 Impact Factor: 1.733
2015 SCImago Journal Rankings: 0.713
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorNikawa, Hen_US
dc.contributor.authorSamaranayake, LPen_US
dc.contributor.authorHamada, Ten_US
dc.date.accessioned2012-08-08T08:22:21Z-
dc.date.available2012-08-08T08:22:21Z-
dc.date.issued1995en_US
dc.identifier.citationArchives Of Oral Biology, 1995, v. 40 n. 6, p. 581-584en_US
dc.identifier.issn0003-9969en_US
dc.identifier.urihttp://hdl.handle.net/10722/153931-
dc.description.abstractThe sensitivity to apo-lactoferrin (apo-LF) of two oral isolates each of Candida albicans and C. krusei preincubated in either sucrose- or tunicamycin-supplemented media was investigated. Known apo-LF-sensitive isolates of both C. albicans and C. krusei demonstrated significantly increased resistance to apo-LF when preincubated in sucrose-supplemented media, but such preincubation had no effect on an apo-LF-resistant isolate of C. albicans, irrespective of the sugar concentration in the medium. Surprisingly, an apo-LF-resistant isolate of C. krusei demonstrated increased susceptibility to apo-LF when preincubated in sucrose. Further, when preincubated with tunicamycin, a chemical that interferes with candidal cell-wall formation, the susceptibility to apo-LF of the resistant isolates increased significantly. These results, when extrapolated in vivo, imply that dietary sucrose may diminish the anticandidal potency of salivary lactoferrin. However, the aberrant behaviour of a single isolate of C. krusei under these circumstances is possibly due to the different cell-wall structure of this yeast and needs to be further investigated.en_US
dc.languageengen_US
dc.publisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/archoralbioen_US
dc.relation.ispartofArchives of Oral Biologyen_US
dc.subject.meshApoproteins - Pharmacologyen_US
dc.subject.meshCandida - Drug Effectsen_US
dc.subject.meshCandida Albicans - Drug Effectsen_US
dc.subject.meshCell Membrane Permeability - Drug Effectsen_US
dc.subject.meshCell Wall - Drug Effectsen_US
dc.subject.meshCulture Mediaen_US
dc.subject.meshDietary Carbohydrates - Pharmacologyen_US
dc.subject.meshDrug Interactionsen_US
dc.subject.meshDrug Resistance, Microbialen_US
dc.subject.meshExtracellular Matrix - Drug Effectsen_US
dc.subject.meshHumansen_US
dc.subject.meshLactoferrin - Pharmacologyen_US
dc.subject.meshSucrose - Pharmacologyen_US
dc.subject.meshTunicamycin - Pharmacologyen_US
dc.titleModulation of the anti-Candida activity of apo-lactoferrin by dietary sucrose and tunicamycin in vitroen_US
dc.typeArticleen_US
dc.identifier.emailSamaranayake, LP:lakshman@hku.hken_US
dc.identifier.authoritySamaranayake, LP=rp00023en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid7677606-
dc.identifier.scopuseid_2-s2.0-0029315235en_US
dc.identifier.hkuros3580-
dc.identifier.hkuros9093-
dc.identifier.volume40en_US
dc.identifier.issue6en_US
dc.identifier.spage581en_US
dc.identifier.epage584en_US
dc.identifier.isiWOS:A1995RE36200019-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridNikawa, H=7006724162en_US
dc.identifier.scopusauthoridSamaranayake, LP=7102761002en_US
dc.identifier.scopusauthoridHamada, T=7401759268en_US

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