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Article: Granulocyte elastase in gingival crevicular fluid: improved monitoring of the site-specific response to treatment in patients with destructive periodontitis.

TitleGranulocyte elastase in gingival crevicular fluid: improved monitoring of the site-specific response to treatment in patients with destructive periodontitis.
Authors
Issue Date1995
PublisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CPE
Citation
Journal Of Clinical Periodontology, 1995, v. 22 n. 3, p. 240-246 How to Cite?
AbstractIn 13 patients with severe destructive periodontitis, the response to periodontal therapy was estimated by granulocyte elastase level in gingival crevicular fluid (GCF). 62 sites were classified according to changes of probing depths (PD) and quantitative bone height (BH%) before and after 5-year regular maintenance treatment: (i) 17 consistently healthy sites with no changes of PD and BH%; (ii) 6 initially healthy sites with deterioration in PD and BH%; (iii) 14 diseased sites with improvement in PD and BH%; (iv) 25 diseased sites with no improvement in PD and BH%. GCF was collected by an intracrevicular washing system. The released elastase in the supernatants (EA-S) and the cell-bound elastase in the pellets (EA-P) were determined with a low molecular weight substrate specific for granulocyte elastase. The ratio of EA-S and EA-P (S/P-ratio) was used as a relative measure of elastase released by the granulocytes present. The sites classified as diseased with no improvement or initially healthy but deteriorating, had significantly higher EA-S, EA-P and S/P-ratios than the consistently healthy sites or diseased but improving sites (p < 0.01). Both EA-S and S/P-ratio showed strongly positive correlations with the current levels of gingival inflammation and periodontal destruction (p < 0.001). The present study suggests that increased elastase level is associated with disease progression, and may be used to monitor the response to longitudinal maintenance therapy.
Persistent Identifierhttp://hdl.handle.net/10722/153922
ISSN
2015 Impact Factor: 3.915
2015 SCImago Journal Rankings: 1.848
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorJin, LJen_US
dc.contributor.authorSöder, POen_US
dc.contributor.authorAsman, Ben_US
dc.contributor.authorBergström, Ken_US
dc.date.accessioned2012-08-08T08:22:18Z-
dc.date.available2012-08-08T08:22:18Z-
dc.date.issued1995en_US
dc.identifier.citationJournal Of Clinical Periodontology, 1995, v. 22 n. 3, p. 240-246en_US
dc.identifier.issn0303-6979en_US
dc.identifier.urihttp://hdl.handle.net/10722/153922-
dc.description.abstractIn 13 patients with severe destructive periodontitis, the response to periodontal therapy was estimated by granulocyte elastase level in gingival crevicular fluid (GCF). 62 sites were classified according to changes of probing depths (PD) and quantitative bone height (BH%) before and after 5-year regular maintenance treatment: (i) 17 consistently healthy sites with no changes of PD and BH%; (ii) 6 initially healthy sites with deterioration in PD and BH%; (iii) 14 diseased sites with improvement in PD and BH%; (iv) 25 diseased sites with no improvement in PD and BH%. GCF was collected by an intracrevicular washing system. The released elastase in the supernatants (EA-S) and the cell-bound elastase in the pellets (EA-P) were determined with a low molecular weight substrate specific for granulocyte elastase. The ratio of EA-S and EA-P (S/P-ratio) was used as a relative measure of elastase released by the granulocytes present. The sites classified as diseased with no improvement or initially healthy but deteriorating, had significantly higher EA-S, EA-P and S/P-ratios than the consistently healthy sites or diseased but improving sites (p < 0.01). Both EA-S and S/P-ratio showed strongly positive correlations with the current levels of gingival inflammation and periodontal destruction (p < 0.001). The present study suggests that increased elastase level is associated with disease progression, and may be used to monitor the response to longitudinal maintenance therapy.en_US
dc.languageengen_US
dc.publisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CPEen_US
dc.relation.ispartofJournal of Clinical Periodontologyen_US
dc.subject.meshAdulten_US
dc.subject.meshAlveolar Bone Loss - Enzymology - Therapyen_US
dc.subject.meshCell-Free System - Enzymologyen_US
dc.subject.meshDisease Progressionen_US
dc.subject.meshFemaleen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshGingival Crevicular Fluid - Enzymologyen_US
dc.subject.meshGingivitis - Enzymology - Therapyen_US
dc.subject.meshGranulocytes - Enzymologyen_US
dc.subject.meshHumansen_US
dc.subject.meshLeukocyte Elastaseen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPancreatic Elastase - Analysisen_US
dc.subject.meshPeriodontal Pocket - Enzymology - Therapyen_US
dc.subject.meshPeriodontitis - Enzymology - Therapyen_US
dc.subject.meshPeriodontium - Enzymologyen_US
dc.titleGranulocyte elastase in gingival crevicular fluid: improved monitoring of the site-specific response to treatment in patients with destructive periodontitis.en_US
dc.typeArticleen_US
dc.identifier.emailJin, LJ:ljjin@hkucc.hku.hken_US
dc.identifier.authorityJin, LJ=rp00028en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid7790531-
dc.identifier.scopuseid_2-s2.0-0029268446en_US
dc.identifier.hkuros3461-
dc.identifier.hkuros13870-
dc.identifier.volume22en_US
dc.identifier.issue3en_US
dc.identifier.spage240en_US
dc.identifier.epage246en_US
dc.identifier.isiWOS:A1995QM99300009-
dc.publisher.placeDenmarken_US
dc.identifier.scopusauthoridJin, LJ=7403328850en_US
dc.identifier.scopusauthoridSöder, PO=7006570984en_US
dc.identifier.scopusauthoridAsman, B=7005314377en_US
dc.identifier.scopusauthoridBergström, K=7102766602en_US

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