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Article: Temporal dynamics of healing in rabbit cranial defects using guided bone regeneration

TitleTemporal dynamics of healing in rabbit cranial defects using guided bone regeneration
Authors
Issue Date1995
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/joms
Citation
Journal Of Oral And Maxillofacial Surgery, 1995, v. 53 n. 2, p. 167-174 How to Cite?
AbstractPurpose: The objective of this study was to histologically evaluate the early stages of bone regeneration using rabbit calvaria defects in conjunction with guided tissue regeneration. Materials: A semilunar cutaneous-periosteal flap was raised on the forehead of four rabbits exposing the top of the skull. A standardized transosseous skull defect (≥ 15 mm in diameter) was made in the area of the right parietal bone with a rotating round bur. Care was taken not to damage the underlying dura. A flat expanded polytetrafluoroethylene (ePTFE) membrane was placed to cover the defect. The membrane was tightly adapted, extending at least 4 mm onto intact bone, and the flap was sutured. One, 2, 3, and 5 weeks later, the specimens were removed and processed using standard, undecalcified, hard-tissue histologic techniques. Contact radiographs were also taken. Results: Bone growth increased with time, starting at the borders of the defect. At 1 week, trabeculae of woven bone grew into the highly vascularized loose connective tissue occupying the defect. Two weeks postsurgery, isolated islands of new bone were detected in this connective tissue. Subsequently, neighboring small islands merged to form large islands. In later stages, the primary trabeculae of woven bone were reinforced by layers of regularly deposited lamellar bone. Conclusion: Rabbit calvaria defects treated by guided tissue regeneration heal by ingrowth of woven bone from the defect margins and by formation of bony islands within the defect area. Bone healing showed the histophysiological characteristics of intramembranous bone.
Persistent Identifierhttp://hdl.handle.net/10722/153910
ISSN
2015 Impact Factor: 1.631
2015 SCImago Journal Rankings: 0.824
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHammerle, CHFen_US
dc.contributor.authorSchmid, Jen_US
dc.contributor.authorLang, NPen_US
dc.contributor.authorOlah, AJen_US
dc.date.accessioned2012-08-08T08:22:14Z-
dc.date.available2012-08-08T08:22:14Z-
dc.date.issued1995en_US
dc.identifier.citationJournal Of Oral And Maxillofacial Surgery, 1995, v. 53 n. 2, p. 167-174en_US
dc.identifier.issn0278-2391en_US
dc.identifier.urihttp://hdl.handle.net/10722/153910-
dc.description.abstractPurpose: The objective of this study was to histologically evaluate the early stages of bone regeneration using rabbit calvaria defects in conjunction with guided tissue regeneration. Materials: A semilunar cutaneous-periosteal flap was raised on the forehead of four rabbits exposing the top of the skull. A standardized transosseous skull defect (≥ 15 mm in diameter) was made in the area of the right parietal bone with a rotating round bur. Care was taken not to damage the underlying dura. A flat expanded polytetrafluoroethylene (ePTFE) membrane was placed to cover the defect. The membrane was tightly adapted, extending at least 4 mm onto intact bone, and the flap was sutured. One, 2, 3, and 5 weeks later, the specimens were removed and processed using standard, undecalcified, hard-tissue histologic techniques. Contact radiographs were also taken. Results: Bone growth increased with time, starting at the borders of the defect. At 1 week, trabeculae of woven bone grew into the highly vascularized loose connective tissue occupying the defect. Two weeks postsurgery, isolated islands of new bone were detected in this connective tissue. Subsequently, neighboring small islands merged to form large islands. In later stages, the primary trabeculae of woven bone were reinforced by layers of regularly deposited lamellar bone. Conclusion: Rabbit calvaria defects treated by guided tissue regeneration heal by ingrowth of woven bone from the defect margins and by formation of bony islands within the defect area. Bone healing showed the histophysiological characteristics of intramembranous bone.en_US
dc.languageengen_US
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/jomsen_US
dc.relation.ispartofJournal of Oral and Maxillofacial Surgeryen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBone Regeneration - Physiologyen_US
dc.subject.meshGuided Tissue Regenerationen_US
dc.subject.meshOsteogenesis - Physiologyen_US
dc.subject.meshParietal Boneen_US
dc.subject.meshPeriosteum - Physiologyen_US
dc.subject.meshPolytetrafluoroethyleneen_US
dc.subject.meshRabbitsen_US
dc.subject.meshSurgical Flapsen_US
dc.subject.meshTime Factorsen_US
dc.subject.meshWound Healing - Physiologyen_US
dc.titleTemporal dynamics of healing in rabbit cranial defects using guided bone regenerationen_US
dc.typeArticleen_US
dc.identifier.emailLang, NP:nplang@hkucc.hku.hken_US
dc.identifier.authorityLang, NP=rp00031en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid7830183-
dc.identifier.scopuseid_2-s2.0-0028816511en_US
dc.identifier.volume53en_US
dc.identifier.issue2en_US
dc.identifier.spage167en_US
dc.identifier.epage174en_US
dc.identifier.isiWOS:A1995QE90000017-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridHammerle, CHF=7005331848en_US
dc.identifier.scopusauthoridSchmid, J=8419181200en_US
dc.identifier.scopusauthoridLang, NP=7201577367en_US
dc.identifier.scopusauthoridOlah, AJ=7006654753en_US

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