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Article: The effect of antifungal agents on the in vitro susceptibility of Candida albicans to apo-lactoferrin

TitleThe effect of antifungal agents on the in vitro susceptibility of Candida albicans to apo-lactoferrin
Authors
Issue Date1994
PublisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/archoralbio
Citation
Archives Of Oral Biology, 1994, v. 39 n. 10, p. 921-923 How to Cite?
AbstractThe effect of subminimal inhibitory concentrations (MICs) of nystatin, amphotericin B, clotrimazole, miconazole and 5-fluorocytosine on the in vitro susceptibility of Candida albicans to physiological concentrations of apo-lactoferrin was investigated. Pre-exposure of C. albicans in 1:4 and 1:16 MICs of the antifungals resulted in an increased resistance to apo-lactoferrin-mediated cell death. Preincubation of Candida in tunicamycin (an agent that inhibits the synthesis of yeast cell-wall mannoproteins) and subsequent exposure to apo-lactoferrin enhanced the antifungal activity, whilst addition of ergosterol (a yeast cell-wall component) to the assay suspension had no significant effect. These results taken together indicate that apo-lactoferrin, an important component of saliva, interacts with cell-membrane constituents of C. albicans such as mannoproteins, and may modulate the effect of topical antifungal agents commonly prescribed for oral candidoses.
Persistent Identifierhttp://hdl.handle.net/10722/153901
ISSN
2015 Impact Factor: 1.733
2015 SCImago Journal Rankings: 0.713
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorNikawa, Hen_US
dc.contributor.authorSamaranayake, LPen_US
dc.contributor.authorTenovuo, Jen_US
dc.contributor.authorHamada, Ten_US
dc.date.accessioned2012-08-08T08:22:11Z-
dc.date.available2012-08-08T08:22:11Z-
dc.date.issued1994en_US
dc.identifier.citationArchives Of Oral Biology, 1994, v. 39 n. 10, p. 921-923en_US
dc.identifier.issn0003-9969en_US
dc.identifier.urihttp://hdl.handle.net/10722/153901-
dc.description.abstractThe effect of subminimal inhibitory concentrations (MICs) of nystatin, amphotericin B, clotrimazole, miconazole and 5-fluorocytosine on the in vitro susceptibility of Candida albicans to physiological concentrations of apo-lactoferrin was investigated. Pre-exposure of C. albicans in 1:4 and 1:16 MICs of the antifungals resulted in an increased resistance to apo-lactoferrin-mediated cell death. Preincubation of Candida in tunicamycin (an agent that inhibits the synthesis of yeast cell-wall mannoproteins) and subsequent exposure to apo-lactoferrin enhanced the antifungal activity, whilst addition of ergosterol (a yeast cell-wall component) to the assay suspension had no significant effect. These results taken together indicate that apo-lactoferrin, an important component of saliva, interacts with cell-membrane constituents of C. albicans such as mannoproteins, and may modulate the effect of topical antifungal agents commonly prescribed for oral candidoses.en_US
dc.languageengen_US
dc.publisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/archoralbioen_US
dc.relation.ispartofArchives of Oral Biologyen_US
dc.subject.meshAmphotericin B - Pharmacologyen_US
dc.subject.meshAntifungal Agents - Pharmacologyen_US
dc.subject.meshApoproteins - Pharmacologyen_US
dc.subject.meshCandida Albicans - Drug Effectsen_US
dc.subject.meshCell Death - Drug Effectsen_US
dc.subject.meshCell Wall - Chemistryen_US
dc.subject.meshClotrimazole - Pharmacologyen_US
dc.subject.meshDrug Resistance, Microbialen_US
dc.subject.meshErgosterol - Pharmacologyen_US
dc.subject.meshFlucytosine - Pharmacologyen_US
dc.subject.meshLactoferrin - Pharmacologyen_US
dc.subject.meshMembrane Glycoproteins - Antagonists & Inhibitorsen_US
dc.subject.meshMiconazole - Pharmacologyen_US
dc.subject.meshNystatin - Pharmacologyen_US
dc.subject.meshTunicamycin - Pharmacologyen_US
dc.titleThe effect of antifungal agents on the in vitro susceptibility of Candida albicans to apo-lactoferrinen_US
dc.typeArticleen_US
dc.identifier.emailSamaranayake, LP:lakshman@hku.hken_US
dc.identifier.authoritySamaranayake, LP=rp00023en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0003-9969(94)90026-4en_US
dc.identifier.pmid7741664en_US
dc.identifier.scopuseid_2-s2.0-0028527855en_US
dc.identifier.hkuros3543-
dc.identifier.volume39en_US
dc.identifier.issue10en_US
dc.identifier.spage921en_US
dc.identifier.epage923en_US
dc.identifier.isiWOS:A1994PQ16800015-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridNikawa, H=7006724162en_US
dc.identifier.scopusauthoridSamaranayake, LP=7102761002en_US
dc.identifier.scopusauthoridTenovuo, J=7005439975en_US
dc.identifier.scopusauthoridHamada, T=7401759268en_US

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