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Article: Delivery of antifungal agents to the oral cavity

TitleDelivery of antifungal agents to the oral cavity
Authors
Keywords5-Fluorocytosine
Anti-Fungal Drugs
Candida
Candidosis
Imidazole Antibiotics
Polyene Antibiotics
Terbinafine
Triazole Antibiotics
Issue Date1994
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/addr
Citation
Advanced Drug Delivery Reviews, 1994, v. 13 n. 1-2, p. 161-179 How to Cite?
AbstractThere is scant information in the literature on the local delivery of antifungal agents within the mouth. Research, therefore, is warranted to evaluate the optimal vehicle for the delivery of the agents to the oral mucosa. A major difficulty for the successful eradication of fungal infections appears to be the dilution and rapid elimination of the drugs from the oral cavity due to the flushing action of saliva. This problem may partly be circumvented by the discovery of the newer triazoles which appear to be effective for most oral candidoses, with only a single dose administration per day and the drug delivered via the systemic route. Nonetheless, whether such newer drugs, with a wide spectrum of activity and minimal toxicity, should be used routinely for oral candidoses merits consideration as emergence of resistant organisms to the triazoles have been now been reported. Accordingly, topical delivery of antifungals remains the most widely accepted approach, with techniques aimed at prolonging drug inhibitory concentrations in the oral cavity. Since most antifungals do not possess inherent ability to bind to oral mucosa, this goal may best be achieved through improved formulations. | There is scant information in the literature on the local delivery of antifungal agents within the mouth. Research, therefore, is warranted to evaluate the optimal vehicle for the delivery of the agents to the oral mucosa. A major difficulty for the successful eradication of fungal infections appears to be the dilution and rapid elimination of the drugs from the oral cavity due to the flushing action of saliva. This problem may partly be circumvented by the discovery of the newer triazoles which appear to be effective for most oral candidoses, with only a single dose administration per day and the drug delivered via the systemic route. Nonetheless, whether such newer drugs, with a wide spectrum of activity and minimal toxicity, should be used routinely for oral candidoses merits consideration as emergence of resistant organisms to the triazoles have now been reported. Accordingly, topical delivery of antifungals remain the most widely accepted approach, with techniques aimed at prolonging drug inhibitory concentrations in the oral cavity. Since most antifungals do not possess inherent ability to bind to oral mucosa, this goal may best be achieved through improved formulations.
Persistent Identifierhttp://hdl.handle.net/10722/153852
ISSN
2015 Impact Factor: 15.606
2015 SCImago Journal Rankings: 5.200

 

DC FieldValueLanguage
dc.contributor.authorSamaranayake, LPen_US
dc.contributor.authorFerguson, MMen_US
dc.date.accessioned2012-08-08T08:21:54Z-
dc.date.available2012-08-08T08:21:54Z-
dc.date.issued1994en_US
dc.identifier.citationAdvanced Drug Delivery Reviews, 1994, v. 13 n. 1-2, p. 161-179en_US
dc.identifier.issn0169-409Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/153852-
dc.description.abstractThere is scant information in the literature on the local delivery of antifungal agents within the mouth. Research, therefore, is warranted to evaluate the optimal vehicle for the delivery of the agents to the oral mucosa. A major difficulty for the successful eradication of fungal infections appears to be the dilution and rapid elimination of the drugs from the oral cavity due to the flushing action of saliva. This problem may partly be circumvented by the discovery of the newer triazoles which appear to be effective for most oral candidoses, with only a single dose administration per day and the drug delivered via the systemic route. Nonetheless, whether such newer drugs, with a wide spectrum of activity and minimal toxicity, should be used routinely for oral candidoses merits consideration as emergence of resistant organisms to the triazoles have been now been reported. Accordingly, topical delivery of antifungals remains the most widely accepted approach, with techniques aimed at prolonging drug inhibitory concentrations in the oral cavity. Since most antifungals do not possess inherent ability to bind to oral mucosa, this goal may best be achieved through improved formulations. | There is scant information in the literature on the local delivery of antifungal agents within the mouth. Research, therefore, is warranted to evaluate the optimal vehicle for the delivery of the agents to the oral mucosa. A major difficulty for the successful eradication of fungal infections appears to be the dilution and rapid elimination of the drugs from the oral cavity due to the flushing action of saliva. This problem may partly be circumvented by the discovery of the newer triazoles which appear to be effective for most oral candidoses, with only a single dose administration per day and the drug delivered via the systemic route. Nonetheless, whether such newer drugs, with a wide spectrum of activity and minimal toxicity, should be used routinely for oral candidoses merits consideration as emergence of resistant organisms to the triazoles have now been reported. Accordingly, topical delivery of antifungals remain the most widely accepted approach, with techniques aimed at prolonging drug inhibitory concentrations in the oral cavity. Since most antifungals do not possess inherent ability to bind to oral mucosa, this goal may best be achieved through improved formulations.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/addren_US
dc.relation.ispartofAdvanced Drug Delivery Reviewsen_US
dc.subject5-Fluorocytosineen_US
dc.subjectAnti-Fungal Drugsen_US
dc.subjectCandidaen_US
dc.subjectCandidosisen_US
dc.subjectImidazole Antibioticsen_US
dc.subjectPolyene Antibioticsen_US
dc.subjectTerbinafineen_US
dc.subjectTriazole Antibioticsen_US
dc.titleDelivery of antifungal agents to the oral cavityen_US
dc.typeArticleen_US
dc.identifier.emailSamaranayake, LP:lakshman@hku.hken_US
dc.identifier.authoritySamaranayake, LP=rp00023en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.scopuseid_2-s2.0-0027972522en_US
dc.identifier.volume13en_US
dc.identifier.issue1-2en_US
dc.identifier.spage161en_US
dc.identifier.epage179en_US
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridSamaranayake, LP=7102761002en_US
dc.identifier.scopusauthoridFerguson, MM=7402593127en_US

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