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Article: Assessment of complement cleavage in gingival fluid during experimental gingivitis in man.

TitleAssessment of complement cleavage in gingival fluid during experimental gingivitis in man.
Authors
Issue Date1989
PublisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CPE
Citation
Journal Of Clinical Periodontology, 1989, v. 16 n. 1, p. 33-37 How to Cite?
AbstractThe cleavage of complement may be an important immunopathologic mechanism in the development of gingival inflammation. Utilizing the experimental gingivitis model, cleavage of C3, C4 and B was assessed in gingival fluid following abstention from oral hygiene. 4 male dental students performed stringent oral hygiene measures until the gingival index approached 0, then refrained from any oral hygiene for 21 days. Gingival fluid, sampled with filter paper strips from the mesial surface of all maxillary premolars at 0, 7, 14, and 21 days, was assayed for C3, C4 and B cleavage by multilayer crossed-immunoelectrophoresis. Clinical indices were assessed following gingival fluid sampling. The subjects, who were plaque-free (PI = 0) at the beginning of the study, showed significant plaque accumulation at day 21 (87% of sites with PI greater than or equal to 2). Approximately 90% of the sites were free from clinical inflammation (GI = 0) at the start, but gingivitis increased with time such that 25% of the sites had GI scores of 2 at day 21. Bleeding on probing to the base of the pocket was not observed at day 0, but was observed at 62% of sites by day 21. Statistical analyses showed that all 3 indices significantly increased with time. The %C3 cleavage increased from a mean of 24% at day 0, to 35%, 45% and then 57% at days 7, 14 and 21, respectively, and both days 14 and 21 demonstrated significantly greater C3 conversion than that seen at day 0. The Spearman rank-order correlation coefficient for %C3 conversion versus time was p = 0.52, significant at the p less than 0.0001 level.(ABSTRACT TRUNCATED AT 250 WORDS)
Persistent Identifierhttp://hdl.handle.net/10722/153676
ISSN
2015 Impact Factor: 3.915
2015 SCImago Journal Rankings: 1.848
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorPatters, MRen_US
dc.contributor.authorNiekrash, CEen_US
dc.contributor.authorLang, NPen_US
dc.date.accessioned2012-08-08T08:20:59Z-
dc.date.available2012-08-08T08:20:59Z-
dc.date.issued1989en_US
dc.identifier.citationJournal Of Clinical Periodontology, 1989, v. 16 n. 1, p. 33-37en_US
dc.identifier.issn0303-6979en_US
dc.identifier.urihttp://hdl.handle.net/10722/153676-
dc.description.abstractThe cleavage of complement may be an important immunopathologic mechanism in the development of gingival inflammation. Utilizing the experimental gingivitis model, cleavage of C3, C4 and B was assessed in gingival fluid following abstention from oral hygiene. 4 male dental students performed stringent oral hygiene measures until the gingival index approached 0, then refrained from any oral hygiene for 21 days. Gingival fluid, sampled with filter paper strips from the mesial surface of all maxillary premolars at 0, 7, 14, and 21 days, was assayed for C3, C4 and B cleavage by multilayer crossed-immunoelectrophoresis. Clinical indices were assessed following gingival fluid sampling. The subjects, who were plaque-free (PI = 0) at the beginning of the study, showed significant plaque accumulation at day 21 (87% of sites with PI greater than or equal to 2). Approximately 90% of the sites were free from clinical inflammation (GI = 0) at the start, but gingivitis increased with time such that 25% of the sites had GI scores of 2 at day 21. Bleeding on probing to the base of the pocket was not observed at day 0, but was observed at 62% of sites by day 21. Statistical analyses showed that all 3 indices significantly increased with time. The %C3 cleavage increased from a mean of 24% at day 0, to 35%, 45% and then 57% at days 7, 14 and 21, respectively, and both days 14 and 21 demonstrated significantly greater C3 conversion than that seen at day 0. The Spearman rank-order correlation coefficient for %C3 conversion versus time was p = 0.52, significant at the p less than 0.0001 level.(ABSTRACT TRUNCATED AT 250 WORDS)en_US
dc.languageengen_US
dc.publisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CPEen_US
dc.relation.ispartofJournal of Clinical Periodontologyen_US
dc.subject.meshComplement Activationen_US
dc.subject.meshComplement C3 - Immunologyen_US
dc.subject.meshComplement C4 - Immunologyen_US
dc.subject.meshComplement Factor B - Immunologyen_US
dc.subject.meshComplement System Proteins - Analysis - Immunologyen_US
dc.subject.meshGingival Crevicular Fluid - Immunologyen_US
dc.subject.meshGingivitis - Immunologyen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunoelectrophoresisen_US
dc.subject.meshLongitudinal Studiesen_US
dc.subject.meshMaleen_US
dc.subject.meshPeriodontal Indexen_US
dc.titleAssessment of complement cleavage in gingival fluid during experimental gingivitis in man.en_US
dc.typeArticleen_US
dc.identifier.emailLang, NP:nplang@hkucc.hku.hken_US
dc.identifier.authorityLang, NP=rp00031en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid2644312-
dc.identifier.scopuseid_2-s2.0-0024528560en_US
dc.identifier.volume16en_US
dc.identifier.issue1en_US
dc.identifier.spage33en_US
dc.identifier.epage37en_US
dc.identifier.isiWOS:A1989R876700006-
dc.publisher.placeDenmarken_US
dc.identifier.scopusauthoridPatters, MR=6701759108en_US
dc.identifier.scopusauthoridNiekrash, CE=6602357617en_US
dc.identifier.scopusauthoridLang, NP=7201577367en_US

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