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Article: On the role of dietary carbohydrates in the pathogenesis of oral candidosis

TitleOn the role of dietary carbohydrates in the pathogenesis of oral candidosis
Authors
Issue Date1985
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journal.asp?ref=0378-1097&site=1
Citation
Fems Microbiology Letters, 1985, v. 27 n. 1, p. 1-5 How to Cite?
AbstractRecent investigations by many workers have elucidated the mechanisms which may explain the clinical observation that an excessive intake of dietary carbohydrates can aggravate oral candidosis. These include the enhancement of growth, multiplication and adherence of Candida species to oral surfaces and the production of excessive quantities of short-chain carboxylic acids as byproducts of sugar metabolism. The resultant acidic milieu, in addition to provoking a mucosal inflammatory reaction, could also activate the highly potent phospholipases and acid proteases of Candida and suppress the growth of normal commensal flora. A unifying hypothesis encompassing the above is proposed to explain the exacerbation of mucosal candidoses observed in environments replete with carbohydrates such as glucose and sucrose.
Persistent Identifierhttp://hdl.handle.net/10722/153574
ISSN
2015 Impact Factor: 1.858
2015 SCImago Journal Rankings: 1.126

 

DC FieldValueLanguage
dc.contributor.authorSamaranayake, LPen_US
dc.contributor.authorMacfarlane, TWen_US
dc.date.accessioned2012-08-08T08:20:26Z-
dc.date.available2012-08-08T08:20:26Z-
dc.date.issued1985en_US
dc.identifier.citationFems Microbiology Letters, 1985, v. 27 n. 1, p. 1-5en_US
dc.identifier.issn0378-1097en_US
dc.identifier.urihttp://hdl.handle.net/10722/153574-
dc.description.abstractRecent investigations by many workers have elucidated the mechanisms which may explain the clinical observation that an excessive intake of dietary carbohydrates can aggravate oral candidosis. These include the enhancement of growth, multiplication and adherence of Candida species to oral surfaces and the production of excessive quantities of short-chain carboxylic acids as byproducts of sugar metabolism. The resultant acidic milieu, in addition to provoking a mucosal inflammatory reaction, could also activate the highly potent phospholipases and acid proteases of Candida and suppress the growth of normal commensal flora. A unifying hypothesis encompassing the above is proposed to explain the exacerbation of mucosal candidoses observed in environments replete with carbohydrates such as glucose and sucrose.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journal.asp?ref=0378-1097&site=1en_US
dc.relation.ispartofFEMS Microbiology Lettersen_US
dc.titleOn the role of dietary carbohydrates in the pathogenesis of oral candidosisen_US
dc.typeArticleen_US
dc.identifier.emailSamaranayake, LP:lakshman@hku.hken_US
dc.identifier.authoritySamaranayake, LP=rp00023en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0378-1097(85)90232-0en_US
dc.identifier.scopuseid_2-s2.0-0022002750en_US
dc.identifier.volume27en_US
dc.identifier.issue1en_US
dc.identifier.spage1en_US
dc.identifier.epage5en_US
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridSamaranayake, LP=7102761002en_US
dc.identifier.scopusauthoridMacFarlane, TW=7005128465en_US

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