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Article: The proteolytic potential of Candida albicans in human saliva supplemented with glucose

TitleThe proteolytic potential of Candida albicans in human saliva supplemented with glucose
Authors
Issue Date1984
PublisherSociety for General Microbiology. The Journal's web site is located at http://jmm.sgmjournals.org
Citation
Journal Of Medical Microbiology, 1984, v. 17 n. 1, p. 13-22 How to Cite?
AbstractThe production of proteases by Candida albicans in batch cultures of human saliva supplemented with glucose was investigated with two clinical strains of Candida and both individual and pooled samples of whole saliva from volunteers. Salivary proteolysis during a 48-h period was estimated by biochemical and isoelectric focusing techniques. Candidal growth in saliva was associated with acid production and salivary proteolysis and there was a highly significant positive correlation between these two activities. Neither candidal growth nor proteolysis was observed in glucose-free control samples and with one strain of Candida cultured in the saliva of one individual. Isotachophoretic analysis of culture liquor showed a significant increase in acetate and pyruvate ions. The oral cavity provides niches that have a low pH and are periodically supplemented with dietary carbohydrates. The acidic proteases of C. albicans may play a role in the pathogenesis of oral candidoses
Persistent Identifierhttp://hdl.handle.net/10722/153561
ISSN
2015 Impact Factor: 2.269
2015 SCImago Journal Rankings: 1.060
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSamaranayake, LPen_US
dc.contributor.authorHughes, Aen_US
dc.contributor.authorMacfarlane, TWen_US
dc.date.accessioned2012-08-08T08:20:22Z-
dc.date.available2012-08-08T08:20:22Z-
dc.date.issued1984en_US
dc.identifier.citationJournal Of Medical Microbiology, 1984, v. 17 n. 1, p. 13-22en_US
dc.identifier.issn0022-2615en_US
dc.identifier.urihttp://hdl.handle.net/10722/153561-
dc.description.abstractThe production of proteases by Candida albicans in batch cultures of human saliva supplemented with glucose was investigated with two clinical strains of Candida and both individual and pooled samples of whole saliva from volunteers. Salivary proteolysis during a 48-h period was estimated by biochemical and isoelectric focusing techniques. Candidal growth in saliva was associated with acid production and salivary proteolysis and there was a highly significant positive correlation between these two activities. Neither candidal growth nor proteolysis was observed in glucose-free control samples and with one strain of Candida cultured in the saliva of one individual. Isotachophoretic analysis of culture liquor showed a significant increase in acetate and pyruvate ions. The oral cavity provides niches that have a low pH and are periodically supplemented with dietary carbohydrates. The acidic proteases of C. albicans may play a role in the pathogenesis of oral candidosesen_US
dc.languageengen_US
dc.publisherSociety for General Microbiology. The Journal's web site is located at http://jmm.sgmjournals.orgen_US
dc.relation.ispartofJournal of Medical Microbiologyen_US
dc.subject.meshAspartic Acid Endopeptidasesen_US
dc.subject.meshCandida Albicans - Enzymology - Growth & Development - Metabolismen_US
dc.subject.meshCarboxylic Acids - Biosynthesisen_US
dc.subject.meshEndopeptidases - Metabolismen_US
dc.subject.meshGlucose - Metabolismen_US
dc.subject.meshHumansen_US
dc.subject.meshHydrogen-Ion Concentrationen_US
dc.subject.meshSaliva - Enzymology - Microbiologyen_US
dc.titleThe proteolytic potential of Candida albicans in human saliva supplemented with glucoseen_US
dc.typeArticleen_US
dc.identifier.emailSamaranayake, LP:lakshman@hku.hken_US
dc.identifier.authoritySamaranayake, LP=rp00023en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid6363704-
dc.identifier.scopuseid_2-s2.0-0021341085en_US
dc.identifier.volume17en_US
dc.identifier.issue1en_US
dc.identifier.spage13en_US
dc.identifier.epage22en_US
dc.identifier.isiWOS:A1984SB48600002-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridSamaranayake, LP=7102761002en_US
dc.identifier.scopusauthoridHughes, A=7401765766en_US
dc.identifier.scopusauthoridMacFarlane, TW=7005128465en_US

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