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Article: Factors affecting the in vitro adherence of the fungal oral pathogen Candida albicans to epithelial cells of human origin

TitleFactors affecting the in vitro adherence of the fungal oral pathogen Candida albicans to epithelial cells of human origin
Authors
Issue Date1982
PublisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/archoralbio
Citation
Archives Of Oral Biology, 1982, v. 27 n. 10, p. 869-873 How to Cite?
AbstractAn in-vitro technique was used to investigate the effects of oral commensal bacteria, serum, saliva, germ-tube formation and pH on the adherence of two strains of C. albicans to HeLa cells. Streptococcus salivarius and Streptococcus mitior reduced candidal adhesion whereas Streptococcus mutans had no significant effect. A mixed salivary pellicle on HeLa cells significantly enhanced candidal adhesion and a serum layer had no effect. Yeasts pre-incubated in whole saliva for 3 h showed significantly greater adhesion to HeLa and human embryonic kidney epithelial cells than yeasts in phosphate-buffered saline. The adherence of hyphal phase candida was significantly greater than in the blastospore phase. Adhesion varied with the pH of the test medium, maximal adherence was at pH 3 with less under neutral pH conditions. The factors involved in the adhesion of C. albicans to epithelial surfaces are complex and may play a role in the aetiopathology of human mucosal candidoses.
Persistent Identifierhttp://hdl.handle.net/10722/153549
ISSN
2015 Impact Factor: 1.733
2015 SCImago Journal Rankings: 0.713
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSamaranayake, LPen_US
dc.contributor.authorMacfarlane, TWen_US
dc.date.accessioned2012-08-08T08:20:19Z-
dc.date.available2012-08-08T08:20:19Z-
dc.date.issued1982en_US
dc.identifier.citationArchives Of Oral Biology, 1982, v. 27 n. 10, p. 869-873en_US
dc.identifier.issn0003-9969en_US
dc.identifier.urihttp://hdl.handle.net/10722/153549-
dc.description.abstractAn in-vitro technique was used to investigate the effects of oral commensal bacteria, serum, saliva, germ-tube formation and pH on the adherence of two strains of C. albicans to HeLa cells. Streptococcus salivarius and Streptococcus mitior reduced candidal adhesion whereas Streptococcus mutans had no significant effect. A mixed salivary pellicle on HeLa cells significantly enhanced candidal adhesion and a serum layer had no effect. Yeasts pre-incubated in whole saliva for 3 h showed significantly greater adhesion to HeLa and human embryonic kidney epithelial cells than yeasts in phosphate-buffered saline. The adherence of hyphal phase candida was significantly greater than in the blastospore phase. Adhesion varied with the pH of the test medium, maximal adherence was at pH 3 with less under neutral pH conditions. The factors involved in the adhesion of C. albicans to epithelial surfaces are complex and may play a role in the aetiopathology of human mucosal candidoses.en_US
dc.languageengen_US
dc.publisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/archoralbioen_US
dc.relation.ispartofArchives of Oral Biologyen_US
dc.subject.meshAdhesivenessen_US
dc.subject.meshCandida Albicans - Physiologyen_US
dc.subject.meshCells, Cultureden_US
dc.subject.meshDental Pellicleen_US
dc.subject.meshEpitheliumen_US
dc.subject.meshHela Cellsen_US
dc.subject.meshHumansen_US
dc.subject.meshHydrogen-Ion Concentrationen_US
dc.subject.meshSalivaen_US
dc.subject.meshStreptococcus - Physiologyen_US
dc.subject.meshStreptococcus Mutans - Physiologyen_US
dc.titleFactors affecting the in vitro adherence of the fungal oral pathogen Candida albicans to epithelial cells of human originen_US
dc.typeArticleen_US
dc.identifier.emailSamaranayake, LP:lakshman@hku.hken_US
dc.identifier.authoritySamaranayake, LP=rp00023en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid6760838en_US
dc.identifier.scopuseid_2-s2.0-0020402345en_US
dc.identifier.volume27en_US
dc.identifier.issue10en_US
dc.identifier.spage869en_US
dc.identifier.epage873en_US
dc.identifier.isiWOS:A1982PM61100013-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridSamaranayake, LP=7102761002en_US
dc.identifier.scopusauthoridMacFarlane, TW=7005128465en_US

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