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Article: The adhesion of the yeast Candida albicans to epithelial cells of human origin in vitro

TitleThe adhesion of the yeast Candida albicans to epithelial cells of human origin in vitro
Authors
Issue Date1981
PublisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/archoralbio
Citation
Archives Of Oral Biology, 1981, v. 26 n. 10, p. 815-820 How to Cite?
AbstractMonolayers of HeLa cells were incubated with Candida suspensions and the number of adherent yeasts per unit area of epithelial cells counted microscopically. Adhesion was proportional to the incubation time and the yeast concentration in the suspension. Preincubation of Candida with sucrose facilitated their adhesion, there being a linear enhancement with increasing sucrose concentrations. The sucrose-facilitated adhesion disappeared when the yeasts were killed prior to incubation in a sucrose-containing medium, suggesting that an extracellular metabolic product could be responsible. On comparison of the adhesion of yeasts to viable and non-viable HeLa cells, greater adhesion to non-viable cells was observed. This experimental system can be used to study parameters influencing candidal adhesion to epithelial surfaces.
Persistent Identifierhttp://hdl.handle.net/10722/153542
ISSN
2015 Impact Factor: 1.733
2015 SCImago Journal Rankings: 0.713
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSamaranayake, LPen_US
dc.contributor.authorMacfarlane, TWen_US
dc.date.accessioned2012-08-08T08:20:16Z-
dc.date.available2012-08-08T08:20:16Z-
dc.date.issued1981en_US
dc.identifier.citationArchives Of Oral Biology, 1981, v. 26 n. 10, p. 815-820en_US
dc.identifier.issn0003-9969en_US
dc.identifier.urihttp://hdl.handle.net/10722/153542-
dc.description.abstractMonolayers of HeLa cells were incubated with Candida suspensions and the number of adherent yeasts per unit area of epithelial cells counted microscopically. Adhesion was proportional to the incubation time and the yeast concentration in the suspension. Preincubation of Candida with sucrose facilitated their adhesion, there being a linear enhancement with increasing sucrose concentrations. The sucrose-facilitated adhesion disappeared when the yeasts were killed prior to incubation in a sucrose-containing medium, suggesting that an extracellular metabolic product could be responsible. On comparison of the adhesion of yeasts to viable and non-viable HeLa cells, greater adhesion to non-viable cells was observed. This experimental system can be used to study parameters influencing candidal adhesion to epithelial surfaces.en_US
dc.languageengen_US
dc.publisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/archoralbioen_US
dc.relation.ispartofArchives of Oral Biologyen_US
dc.subject.meshAdhesivenessen_US
dc.subject.meshCandida Albicans - Drug Effects - Physiologyen_US
dc.subject.meshCell Lineen_US
dc.subject.meshCell Survival - Drug Effectsen_US
dc.subject.meshEpithelial Cellsen_US
dc.subject.meshEpithelium - Drug Effectsen_US
dc.subject.meshFormaldehyde - Pharmacologyen_US
dc.subject.meshHela Cellsen_US
dc.subject.meshHumansen_US
dc.subject.meshSucrose - Pharmacologyen_US
dc.titleThe adhesion of the yeast Candida albicans to epithelial cells of human origin in vitroen_US
dc.typeArticleen_US
dc.identifier.emailSamaranayake, LP:lakshman@hku.hken_US
dc.identifier.authoritySamaranayake, LP=rp00023en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid7036964-
dc.identifier.scopuseid_2-s2.0-0019783156-
dc.identifier.volume26en_US
dc.identifier.issue10en_US
dc.identifier.spage815en_US
dc.identifier.epage820en_US
dc.identifier.isiWOS:A1981MP81100008-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridSamaranayake, LP=7102761002en_US
dc.identifier.scopusauthoridMacFarlane, TW=7005128465en_US

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