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Article: Optimal dosage of chlorhexidine digluconate in chemical plaque control when applied by the oral irrigator

TitleOptimal dosage of chlorhexidine digluconate in chemical plaque control when applied by the oral irrigator
Authors
Issue Date1981
PublisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CPE
Citation
Journal Of Clinical Periodontology, 1981, v. 8 n. 3, p. 189-202 How to Cite?
AbstractChlorhexidine digluconate for chemical plaque control was tested in different concentrations using a fractionated jet oral irrigator. The inhibition of plaque formation and the prevention of gingival inflammation were evaluated in a double-blind study. During a 10-day period of abstinence from any mechanical oral hygiene procedures, the pattern of plaque formation and gingivitis development under the influence of chemical plaque control was analyzed. As a positive control, one group rinsed twice daily with 30 ml of a 0.2% chlorhexidine solution while a group applying 600 ml of a placebo solution served as a negative control. Forty dental students and assistants with plaque-free dentitions and healthy gingival tissues were divided into four groups. After a 10-day period of no oral hygiene, a recovery period of 11 days with perfect oral hygiene was again instituted. This experiment was repeated three times so that a total of 10 concentrations in the irrigator, the control rinsing and the placebo control could be evaluated. Daily application of 600 ml of a 0.001% (6 mg), 0.0033% (20mg), 0.005% (30 mg), 0.01% (60mg), 0.02% (120mg), 0.05% (300mg) and 0.1% (600 mg) and 400 ml of a 0.015% (60 mg), twice 400 ml of a 0.015% (120 mg) and 400 ml of a 0.02% (80 mg) solution of chlorhexidine was tested. At the start of each experimental period (day 0), after 3, 7 and 10 days and 11 days following reassuming oral hygiene procedures, the plaque accumulations were determined using the Plaque Index System (Silness & Loe 1964) and the development of gingivitis was evaluated according to the criteria of the Gingival Index System (Loe & Silness 1963). The results suggested that one daily irrigator application of 400 ml of a 0.02% chlorhexidine solution was the optimal and lowest concentration and dose to be used for complete inhibition of dental plaque.
Persistent Identifierhttp://hdl.handle.net/10722/153537
ISSN
2015 Impact Factor: 3.915
2015 SCImago Journal Rankings: 1.848
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLang, NPen_US
dc.contributor.authorRamseierGrossmann, Ken_US
dc.date.accessioned2012-08-08T08:20:15Z-
dc.date.available2012-08-08T08:20:15Z-
dc.date.issued1981en_US
dc.identifier.citationJournal Of Clinical Periodontology, 1981, v. 8 n. 3, p. 189-202en_US
dc.identifier.issn0303-6979en_US
dc.identifier.urihttp://hdl.handle.net/10722/153537-
dc.description.abstractChlorhexidine digluconate for chemical plaque control was tested in different concentrations using a fractionated jet oral irrigator. The inhibition of plaque formation and the prevention of gingival inflammation were evaluated in a double-blind study. During a 10-day period of abstinence from any mechanical oral hygiene procedures, the pattern of plaque formation and gingivitis development under the influence of chemical plaque control was analyzed. As a positive control, one group rinsed twice daily with 30 ml of a 0.2% chlorhexidine solution while a group applying 600 ml of a placebo solution served as a negative control. Forty dental students and assistants with plaque-free dentitions and healthy gingival tissues were divided into four groups. After a 10-day period of no oral hygiene, a recovery period of 11 days with perfect oral hygiene was again instituted. This experiment was repeated three times so that a total of 10 concentrations in the irrigator, the control rinsing and the placebo control could be evaluated. Daily application of 600 ml of a 0.001% (6 mg), 0.0033% (20mg), 0.005% (30 mg), 0.01% (60mg), 0.02% (120mg), 0.05% (300mg) and 0.1% (600 mg) and 400 ml of a 0.015% (60 mg), twice 400 ml of a 0.015% (120 mg) and 400 ml of a 0.02% (80 mg) solution of chlorhexidine was tested. At the start of each experimental period (day 0), after 3, 7 and 10 days and 11 days following reassuming oral hygiene procedures, the plaque accumulations were determined using the Plaque Index System (Silness & Loe 1964) and the development of gingivitis was evaluated according to the criteria of the Gingival Index System (Loe & Silness 1963). The results suggested that one daily irrigator application of 400 ml of a 0.02% chlorhexidine solution was the optimal and lowest concentration and dose to be used for complete inhibition of dental plaque.en_US
dc.languageengen_US
dc.publisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CPEen_US
dc.relation.ispartofJournal of Clinical Periodontologyen_US
dc.subject.meshAdulten_US
dc.subject.meshChlorhexidine - Administration & Dosage - Analogs & Derivatives - Therapeutic Useen_US
dc.subject.meshDental Devices, Home Careen_US
dc.subject.meshDental Plaque - Analysis - Prevention & Controlen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshDouble-Blind Methoden_US
dc.subject.meshGingivitis - Prevention & Controlen_US
dc.subject.meshHumansen_US
dc.subject.meshMouthwashesen_US
dc.subject.meshPeriodontal Indexen_US
dc.subject.meshTherapeutic Irrigation - Instrumentationen_US
dc.subject.meshTime Factorsen_US
dc.titleOptimal dosage of chlorhexidine digluconate in chemical plaque control when applied by the oral irrigatoren_US
dc.typeArticleen_US
dc.identifier.emailLang, NP:nplang@hkucc.hku.hken_US
dc.identifier.authorityLang, NP=rp00031en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid6947985-
dc.identifier.scopuseid_2-s2.0-0019518338en_US
dc.identifier.volume8en_US
dc.identifier.issue3en_US
dc.identifier.spage189en_US
dc.identifier.epage202en_US
dc.identifier.isiWOS:A1981MF12000004-
dc.publisher.placeDenmarken_US
dc.identifier.scopusauthoridLang, NP=7201577367en_US
dc.identifier.scopusauthoridRamseierGrossmann, K=6505546865en_US

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