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Article: Lymphocyte blastogenesis to plaque antigens in human periodontal disease. I. Populations of varying severity of disease

TitleLymphocyte blastogenesis to plaque antigens in human periodontal disease. I. Populations of varying severity of disease
Authors
Issue Date1977
PublisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0022-3484&site=1
Citation
Journal Of Periodontal Research, 1977, v. 12 n. 4, p. 298-309 How to Cite?
AbstractLymphocyte transformation in response to dental plaque antigens was used to determine the association between cellular immune response and the periodontal status in man. An in vitro system for lymphocyte transformation was used. Triplicate microcultures of peripheral blood lymphocytes were stimulated with four different concentrations of V. alcalescens, B. melaninogenicus, F. nucleatum, A. viscosus, A. naeslundii, S. sanguis and pooled plaque of human origin. Phytohemagglutinin served as a positive and saline as a negative control. The uptake of 3H-thymidine during blastogenesis was measured by liquid scintillation counting. 48 subjects divided into four equal groups of individuals with either normal gingivae, gingivitis, mild to moderate, or advanced periodontitis participated in the study. The subjects were all between 35 and 45 years of age. The peripheral blood lymphocytes of the normal subjects did not generally undergo blastogenesis with any of the organisms. However, when blastogenesis occurred in other groups, the highest stimulation was found in the advanced periodontitis group. B. melaninogenicus stimulated blastogenesis only in the advanced group. A. viscosus and A. naeslundii stimulated lymphocytes to various degrees in all except the normal group. All the other antigens did not show any differences in stimulations between any of the groups.
Persistent Identifierhttp://hdl.handle.net/10722/153517
ISSN
2015 Impact Factor: 2.474
2015 SCImago Journal Rankings: 0.932
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLang, NPen_US
dc.contributor.authorSmith, FNen_US
dc.date.accessioned2012-08-08T08:20:09Z-
dc.date.available2012-08-08T08:20:09Z-
dc.date.issued1977en_US
dc.identifier.citationJournal Of Periodontal Research, 1977, v. 12 n. 4, p. 298-309en_US
dc.identifier.issn0022-3484en_US
dc.identifier.urihttp://hdl.handle.net/10722/153517-
dc.description.abstractLymphocyte transformation in response to dental plaque antigens was used to determine the association between cellular immune response and the periodontal status in man. An in vitro system for lymphocyte transformation was used. Triplicate microcultures of peripheral blood lymphocytes were stimulated with four different concentrations of V. alcalescens, B. melaninogenicus, F. nucleatum, A. viscosus, A. naeslundii, S. sanguis and pooled plaque of human origin. Phytohemagglutinin served as a positive and saline as a negative control. The uptake of 3H-thymidine during blastogenesis was measured by liquid scintillation counting. 48 subjects divided into four equal groups of individuals with either normal gingivae, gingivitis, mild to moderate, or advanced periodontitis participated in the study. The subjects were all between 35 and 45 years of age. The peripheral blood lymphocytes of the normal subjects did not generally undergo blastogenesis with any of the organisms. However, when blastogenesis occurred in other groups, the highest stimulation was found in the advanced periodontitis group. B. melaninogenicus stimulated blastogenesis only in the advanced group. A. viscosus and A. naeslundii stimulated lymphocytes to various degrees in all except the normal group. All the other antigens did not show any differences in stimulations between any of the groups.en_US
dc.languageengen_US
dc.publisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0022-3484&site=1en_US
dc.relation.ispartofJournal of Periodontal Researchen_US
dc.subject.meshAdulten_US
dc.subject.meshAntigens, Bacterial - Isolation & Purificationen_US
dc.subject.meshCells, Cultureden_US
dc.subject.meshDental Plaque - Immunologyen_US
dc.subject.meshGingivitis - Immunologyen_US
dc.subject.meshHumansen_US
dc.subject.meshLymphocyte Activationen_US
dc.subject.meshMethodsen_US
dc.subject.meshPeriodontal Diseases - Immunologyen_US
dc.subject.meshPeriodontitis - Immunologyen_US
dc.titleLymphocyte blastogenesis to plaque antigens in human periodontal disease. I. Populations of varying severity of diseaseen_US
dc.typeArticleen_US
dc.identifier.emailLang, NP:nplang@hkucc.hku.hken_US
dc.identifier.authorityLang, NP=rp00031en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid142139-
dc.identifier.scopuseid_2-s2.0-0017737101en_US
dc.identifier.volume12en_US
dc.identifier.issue4en_US
dc.identifier.spage298en_US
dc.identifier.epage309en_US
dc.identifier.isiWOS:A1977DK67800009-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLang, NP=7201577367en_US
dc.identifier.scopusauthoridSmith, FN=7402856529en_US

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