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Article: Lymphocyte blastogenesis to plaque antigens in human periodontal disease. II. The relationship to clinical parameters

TitleLymphocyte blastogenesis to plaque antigens in human periodontal disease. II. The relationship to clinical parameters
Authors
Issue Date1977
PublisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0022-3484&site=1
Citation
Journal Of Periodontal Research, 1977, v. 12 n. 4, p. 310-317 How to Cite?
AbstractThis study undertook to correlate lymphocyte transformation to human dental plaque antigens with clinical estimates of periodontal disease. 48 patients with periodontal conditions ranging from normal gingivae to severe periodontitis were examined clinically. Oral cleanliness was determined by the Plaque Index System and gingival health was assessed using the criteria of the Gingival Index System. Pocket depth and loss of periodontal attachment from the cementoenamel junction were also measured. Triplicate microcultures of peripheral blood lymphocytes were stimulated with four different concentrations of human plaque antigens. The uptake of 3H-thymidine during blastogenesis was measured by liquid scintillation counting. There was no correlation between the stimulation by most of the isolated plaque antigens or pooled plaque and the periodontal conditions as determined by plaque index, gingival index, pocket depth and loss of attachment. However, there was a significant, although low, correlation between clinical parameters and the stimulation of peripheral blood lymphocytes by B. melaninogenicus and A. viscosus. Stimulation with B. melaninogenicus correlated more highly with pocket depth and loss of attachment, while stimulation with A. viscosus and A. naeslundii correlated more highly with plaque and gingivitis scores. The possible role of these organisms in the pathogenesis of periodontal disease involving cellular immunity was discussed as was the interpretation of data obtained in blastogenesis using peripheral blood lymphocytes and its relevance to the local phenomenon of delayed hypersensitivity.
Persistent Identifierhttp://hdl.handle.net/10722/153516
ISSN
2015 Impact Factor: 2.474
2015 SCImago Journal Rankings: 0.932
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSmith, FNen_US
dc.contributor.authorLang, NPen_US
dc.date.accessioned2012-08-08T08:20:08Z-
dc.date.available2012-08-08T08:20:08Z-
dc.date.issued1977en_US
dc.identifier.citationJournal Of Periodontal Research, 1977, v. 12 n. 4, p. 310-317en_US
dc.identifier.issn0022-3484en_US
dc.identifier.urihttp://hdl.handle.net/10722/153516-
dc.description.abstractThis study undertook to correlate lymphocyte transformation to human dental plaque antigens with clinical estimates of periodontal disease. 48 patients with periodontal conditions ranging from normal gingivae to severe periodontitis were examined clinically. Oral cleanliness was determined by the Plaque Index System and gingival health was assessed using the criteria of the Gingival Index System. Pocket depth and loss of periodontal attachment from the cementoenamel junction were also measured. Triplicate microcultures of peripheral blood lymphocytes were stimulated with four different concentrations of human plaque antigens. The uptake of 3H-thymidine during blastogenesis was measured by liquid scintillation counting. There was no correlation between the stimulation by most of the isolated plaque antigens or pooled plaque and the periodontal conditions as determined by plaque index, gingival index, pocket depth and loss of attachment. However, there was a significant, although low, correlation between clinical parameters and the stimulation of peripheral blood lymphocytes by B. melaninogenicus and A. viscosus. Stimulation with B. melaninogenicus correlated more highly with pocket depth and loss of attachment, while stimulation with A. viscosus and A. naeslundii correlated more highly with plaque and gingivitis scores. The possible role of these organisms in the pathogenesis of periodontal disease involving cellular immunity was discussed as was the interpretation of data obtained in blastogenesis using peripheral blood lymphocytes and its relevance to the local phenomenon of delayed hypersensitivity.en_US
dc.languageengen_US
dc.publisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0022-3484&site=1en_US
dc.relation.ispartofJournal of Periodontal Researchen_US
dc.subject.meshAdulten_US
dc.subject.meshAntigens, Bacterialen_US
dc.subject.meshDental Plaque - Immunologyen_US
dc.subject.meshGingival Pocket - Immunologyen_US
dc.subject.meshGingivitis - Immunologyen_US
dc.subject.meshHumansen_US
dc.subject.meshLymphocyte Activationen_US
dc.subject.meshOral Hygieneen_US
dc.subject.meshPeriodontal Diseases - Immunologyen_US
dc.subject.meshPeriodontitis - Immunologyen_US
dc.subject.meshRegression Analysisen_US
dc.titleLymphocyte blastogenesis to plaque antigens in human periodontal disease. II. The relationship to clinical parametersen_US
dc.typeArticleen_US
dc.identifier.emailLang, NP:nplang@hkucc.hku.hken_US
dc.identifier.authorityLang, NP=rp00031en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid142140en_US
dc.identifier.scopuseid_2-s2.0-0017702321en_US
dc.identifier.volume12en_US
dc.identifier.issue4en_US
dc.identifier.spage310en_US
dc.identifier.epage317en_US
dc.identifier.isiWOS:A1977DK67800010-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridSmith, FN=7402856529en_US
dc.identifier.scopusauthoridLang, NP=7201577367en_US

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