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Conference Paper: A randomised clinical trial comparing thesublingual and buccal routes of administration ofmisoprostol after mifepristone for medicaltermination of pregnancy of up to 63 days ofgestation
Title | A randomised clinical trial comparing thesublingual and buccal routes of administration ofmisoprostol after mifepristone for medicaltermination of pregnancy of up to 63 days ofgestation |
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Authors | |
Issue Date | 2012 |
Publisher | Wiley-Blackwell Publishing Ltd.. The Journal's web site is located at http://www.bjog.org/ |
Citation | The RCOG 10th International Scientific Congress, Kuching, Sarawak, Malaysia, 5-8 June 2012. In BJOG, 2012, v. 119 suppl. s1, p. 139 How to Cite? |
Abstract | Objective: Buccal misoprostol 800 mcg and sublingual 800 mcgshow high efficacy when used with 200 mg mifepristone for earlypregnancy termination but with different profiles of side effects.This is the first double-blind randomized trial comparing thesetwo routes for termination of early pregnancies up to 63 daysgestation.Methods: Eligible women (n = 90) who requested legaltermination of pregnancy up to 63 days gestation wererandomized to two groups and given 200 mg of oral mifepristonefollowed 48 h later by either 800 mcg of sublingual (n = 45) orbuccal (n = 45) misoprostol.Results: Similar proportion of women experienced fever insublingual and buccal groups (37.8% vs. 22.2%, P = 0.107). Theincidence of chills was significantly higher in the sublingual group(55.6% vs. 91.1%, P = 0.0001). Complete termination ofpregnancy occurred in 95.4% (95% CI: 84.9–99.5) of women inthe buccal group and 97.8% (95% CI: 88.2–99.9) in the sublingualgroup. Conclusions: When combined with mifepristone for terminationof pregnancy up to 63 days, sublingual administration ofmisoprostol is associated with more chills but not other sideeffects when compared with buccal administration. |
Persistent Identifier | http://hdl.handle.net/10722/153218 |
ISSN | 2023 Impact Factor: 4.7 2023 SCImago Journal Rankings: 1.858 |
DC Field | Value | Language |
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dc.contributor.author | Chai, J | - |
dc.contributor.author | Ho, PC | - |
dc.date.accessioned | 2012-07-16T10:00:21Z | - |
dc.date.available | 2012-07-16T10:00:21Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | The RCOG 10th International Scientific Congress, Kuching, Sarawak, Malaysia, 5-8 June 2012. In BJOG, 2012, v. 119 suppl. s1, p. 139 | - |
dc.identifier.issn | 1470-0328 | - |
dc.identifier.uri | http://hdl.handle.net/10722/153218 | - |
dc.description.abstract | Objective: Buccal misoprostol 800 mcg and sublingual 800 mcgshow high efficacy when used with 200 mg mifepristone for earlypregnancy termination but with different profiles of side effects.This is the first double-blind randomized trial comparing thesetwo routes for termination of early pregnancies up to 63 daysgestation.Methods: Eligible women (n = 90) who requested legaltermination of pregnancy up to 63 days gestation wererandomized to two groups and given 200 mg of oral mifepristonefollowed 48 h later by either 800 mcg of sublingual (n = 45) orbuccal (n = 45) misoprostol.Results: Similar proportion of women experienced fever insublingual and buccal groups (37.8% vs. 22.2%, P = 0.107). Theincidence of chills was significantly higher in the sublingual group(55.6% vs. 91.1%, P = 0.0001). Complete termination ofpregnancy occurred in 95.4% (95% CI: 84.9–99.5) of women inthe buccal group and 97.8% (95% CI: 88.2–99.9) in the sublingualgroup. Conclusions: When combined with mifepristone for terminationof pregnancy up to 63 days, sublingual administration ofmisoprostol is associated with more chills but not other sideeffects when compared with buccal administration. | - |
dc.language | eng | - |
dc.publisher | Wiley-Blackwell Publishing Ltd.. The Journal's web site is located at http://www.bjog.org/ | - |
dc.relation.ispartof | BJOG: an international journal of obstetrics and gynaecology | - |
dc.title | A randomised clinical trial comparing thesublingual and buccal routes of administration ofmisoprostol after mifepristone for medicaltermination of pregnancy of up to 63 days ofgestation | - |
dc.type | Conference_Paper | - |
dc.identifier.email | Chai, J: jchai@hkucc.hku.hk | - |
dc.identifier.email | Ho, PC: pcho@hku.hk | - |
dc.identifier.authority | Chai, J=rp00241 | - |
dc.identifier.authority | Ho, PC=rp00325 | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1111/j.1471-0528.2012.03378.x | - |
dc.identifier.hkuros | 200623 | - |
dc.identifier.volume | 119 | - |
dc.identifier.issue | suppl. s1 | - |
dc.identifier.spage | 139 | - |
dc.identifier.epage | 139 | - |
dc.publisher.place | United Kingdom | - |
dc.identifier.issnl | 1470-0328 | - |