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Conference Paper: Prediction of surgical outcome using plasma Epstein-Barr Virus DNA and 18F-FDG PET-CT scan in recurrent nasopharyngeal carcinoma

TitlePrediction of surgical outcome using plasma Epstein-Barr Virus DNA and 18F-FDG PET-CT scan in recurrent nasopharyngeal carcinoma
Authors
KeywordsMedical sciences
Otorhinolaryngology
Issue Date2012
PublisherSpringer Verlag.
Citation
The 5th European Conference On Head & Neck Oncology (ECHNO 2012), Poznan, Poland, 19-21 April 2012. In European Archives of Oto-Rhino-Laryngology, 2012, v. 269 n. 4, p. 1325, abstract no. OP20 How to Cite?
AbstractBACKGROUND: To determine the role of plasma Epstein–Barr Virus (pEBV)-DNA and PET-CT scan in predicting the outcome of nasopharyngectomy and cervical lymphadenectomy for recurrent nasopharyngeal carcinoma (NPC). METHODS: Between 2007 and 2009, we recruited patients who had local or regional recurrent NPC after radiotherapy. Relationship between pre-operative pEBV-DNA level, SUVmax and surgical outcome was analyzed. RESULTS: Forty-two patients had local tumor recurrence. Their median pEBV-DNA level and SUVmax were 348 copies and 4.7, respectively. Both values were significantly lower than those with palliative nasopharyngectomy. Twenty-two patients had regional failure. Their mean pEBV DNA level and tumor SUVmax were 626 copies and 7.6, respectively. The metastatic lymph nodes with extra-capsular spread had significantly higher mean SUVmax. CONCLUSIONS: Pre-operative pEBV-DNA and PET-CT predict a surgical outcome of nasopharyngectomy for recurrent NPC. Similarly, PET-CT scan predicts the presence of extra-capsular spread of metastatic lymph nodes. These patients may warrant further postoperative adjuvant therapy.
DescriptionThis journal issue entitled: Abstracts for the 5th European Conference on Head and Neck Oncology 18–21 April 2012 in Poznan, Poland
Oral presentations: OP20
Persistent Identifierhttp://hdl.handle.net/10722/153145
ISSN
2015 Impact Factor: 1.627
2015 SCImago Journal Rankings: 0.755

 

DC FieldValueLanguage
dc.contributor.authorChan, JYWen_US
dc.contributor.authorWei, WI-
dc.date.accessioned2012-07-16T09:58:06Z-
dc.date.available2012-07-16T09:58:06Z-
dc.date.issued2012en_US
dc.identifier.citationThe 5th European Conference On Head & Neck Oncology (ECHNO 2012), Poznan, Poland, 19-21 April 2012. In European Archives of Oto-Rhino-Laryngology, 2012, v. 269 n. 4, p. 1325, abstract no. OP20en_US
dc.identifier.issn0937-4477-
dc.identifier.urihttp://hdl.handle.net/10722/153145-
dc.descriptionThis journal issue entitled: Abstracts for the 5th European Conference on Head and Neck Oncology 18–21 April 2012 in Poznan, Poland-
dc.descriptionOral presentations: OP20-
dc.description.abstractBACKGROUND: To determine the role of plasma Epstein–Barr Virus (pEBV)-DNA and PET-CT scan in predicting the outcome of nasopharyngectomy and cervical lymphadenectomy for recurrent nasopharyngeal carcinoma (NPC). METHODS: Between 2007 and 2009, we recruited patients who had local or regional recurrent NPC after radiotherapy. Relationship between pre-operative pEBV-DNA level, SUVmax and surgical outcome was analyzed. RESULTS: Forty-two patients had local tumor recurrence. Their median pEBV-DNA level and SUVmax were 348 copies and 4.7, respectively. Both values were significantly lower than those with palliative nasopharyngectomy. Twenty-two patients had regional failure. Their mean pEBV DNA level and tumor SUVmax were 626 copies and 7.6, respectively. The metastatic lymph nodes with extra-capsular spread had significantly higher mean SUVmax. CONCLUSIONS: Pre-operative pEBV-DNA and PET-CT predict a surgical outcome of nasopharyngectomy for recurrent NPC. Similarly, PET-CT scan predicts the presence of extra-capsular spread of metastatic lymph nodes. These patients may warrant further postoperative adjuvant therapy.-
dc.languageengen_US
dc.publisherSpringer Verlag.-
dc.relation.ispartofEuropean Archives of Oto-Rhino-Laryngologyen_US
dc.rightsThe original publication is available at www.springerlink.com-
dc.subjectMedical sciences-
dc.subjectOtorhinolaryngology-
dc.titlePrediction of surgical outcome using plasma Epstein-Barr Virus DNA and 18F-FDG PET-CT scan in recurrent nasopharyngeal carcinomaen_US
dc.typeConference_Paperen_US
dc.identifier.emailChan, JYW: jywchan1@hku.hken_US
dc.identifier.emailWei, WI: hrmswwi@hku.hk-
dc.identifier.authorityChan, JYW=rp01314en_US
dc.identifier.hkuros200772en_US
dc.identifier.volume269-
dc.identifier.issue4-
dc.identifier.spage1325-
dc.identifier.epage1325-
dc.publisher.placeGermany-

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