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Conference Paper: Activation of lytic cycle of Epstein-Barr virus by suberoylanilide hydroxamic acid affects apoptosis and tumor growth suppression of nasopharyngeal carcinoma

TitleActivation of lytic cycle of Epstein-Barr virus by suberoylanilide hydroxamic acid affects apoptosis and tumor growth suppression of nasopharyngeal carcinoma
Authors
Issue Date2012
PublisherAmerican Association for Cancer Research.
Citation
The Annual Meeting of the American Association for Cancer Research (AACR 2012), Chicago, IL., 31 March-4 April 2012. How to Cite?
AbstractNasopharyngeal carcinoma (NPC) is strongly associated with Epstein-Barr virus (EBV). We examined the in vitro and in vivo effects of suberoylanilide hydroxamic acid (SAHA), a FDA-approved histone deacetylase inhibitor, on EBV lytic cycle induction in NPC and investigated the cellular consequences. Micromolar concentrations of SAHA potently induced EBV lytic cycle with replication of EBV DNA, expression of immediate early (Zta and Rta), early (BMRF1) and late (gp350) lytic proteins and production of infectious viral particles in ...
DescriptionPoster Session 31 - Inhibitors of Epigenetic and Gene Regulatory Targets: abstract no. 4715
Persistent Identifierhttp://hdl.handle.net/10722/153128

 

DC FieldValueLanguage
dc.contributor.authorChiang, AKSen_US
dc.contributor.authorHui, KFen_US
dc.date.accessioned2012-07-16T09:57:35Z-
dc.date.available2012-07-16T09:57:35Z-
dc.date.issued2012en_US
dc.identifier.citationThe Annual Meeting of the American Association for Cancer Research (AACR 2012), Chicago, IL., 31 March-4 April 2012.en_US
dc.identifier.urihttp://hdl.handle.net/10722/153128-
dc.descriptionPoster Session 31 - Inhibitors of Epigenetic and Gene Regulatory Targets: abstract no. 4715-
dc.description.abstractNasopharyngeal carcinoma (NPC) is strongly associated with Epstein-Barr virus (EBV). We examined the in vitro and in vivo effects of suberoylanilide hydroxamic acid (SAHA), a FDA-approved histone deacetylase inhibitor, on EBV lytic cycle induction in NPC and investigated the cellular consequences. Micromolar concentrations of SAHA potently induced EBV lytic cycle with replication of EBV DNA, expression of immediate early (Zta and Rta), early (BMRF1) and late (gp350) lytic proteins and production of infectious viral particles in ...-
dc.languageengen_US
dc.publisherAmerican Association for Cancer Research.-
dc.relation.ispartofAnnual Meeting of the American Association for Cancer Research, AACR 2012en_US
dc.titleActivation of lytic cycle of Epstein-Barr virus by suberoylanilide hydroxamic acid affects apoptosis and tumor growth suppression of nasopharyngeal carcinomaen_US
dc.typeConference_Paperen_US
dc.identifier.emailChiang, AKS: chiangak@hku.hken_US
dc.identifier.emailHui, KF: kfhui@hku.hken_US
dc.identifier.authorityChiang, AKS=rp00403en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.hkuros200659en_US
dc.publisher.placeUnited States-
dc.description.otherThe Annual Meeting of the American Association for Cancer Research (AACR 2012), Chicago, IL., 31 March-4 April 2012.-

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