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Article: Anti-cancer effects of curcumin on head and neck cancers

TitleAnti-cancer effects of curcumin on head and neck cancers
Authors
KeywordsChemotherapeutic agent
Curcumin
Epigenetics regulation
Head and neck cancer
Matrix Metalloproteinases
Issue Date2012
PublisherBentham Science Publishers Ltd. The Journal's web site is located at http://www.bentham.org/cmcaca
Citation
Anti-Cancer Agents in Medicinal Chemistry, 2012, v. 12 n. 9, p. 1110-1116 How to Cite?
AbstractHead and neck cancer is the sixth large type of cancer in the world. The treatment regimens for head and neck cancer encompass surgery, radiotherapy and chemotherapy. However, all current treatment regimens for head and neck cancer have adverse effects. Therefore, continuing investigations have been undertaken to seek less toxic therapies to reduce treatment morbidity for head and neck cancer. Substantial evidence has demonstrated that curcumin inhibited proliferation, migration, invasion and metastasis and induced apoptosis via modulating multiple signaling pathways in head and neck cancer. Curcumin also suppressed the growth of xenograft derived from head and neck cancer in vivo in animal models. This review summarizes the evidence demonstrating potential use of curcumin as a single chemotherapeutic agent or in combination with other chemotherapeutic agents and radiation to minimize their toxicity in head and neck cancer. Although curcumin has been shown to be safe at doses of 8 g/d in both phase I and phase II clinical trials, its bioavailability is poor. Overcoming the poor bioavailability of curcumin in the near future would facilitate its clinical use.
Persistent Identifierhttp://hdl.handle.net/10722/152867
ISSN
2015 Impact Factor: 2.722
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorGao, Wen_US
dc.contributor.authorChan, JYWen_US
dc.contributor.authorWei, WIen_US
dc.contributor.authorWong, TSen_US
dc.date.accessioned2012-07-16T09:51:02Z-
dc.date.available2012-07-16T09:51:02Z-
dc.date.issued2012en_US
dc.identifier.citationAnti-Cancer Agents in Medicinal Chemistry, 2012, v. 12 n. 9, p. 1110-1116en_US
dc.identifier.issn1871-5206-
dc.identifier.urihttp://hdl.handle.net/10722/152867-
dc.description.abstractHead and neck cancer is the sixth large type of cancer in the world. The treatment regimens for head and neck cancer encompass surgery, radiotherapy and chemotherapy. However, all current treatment regimens for head and neck cancer have adverse effects. Therefore, continuing investigations have been undertaken to seek less toxic therapies to reduce treatment morbidity for head and neck cancer. Substantial evidence has demonstrated that curcumin inhibited proliferation, migration, invasion and metastasis and induced apoptosis via modulating multiple signaling pathways in head and neck cancer. Curcumin also suppressed the growth of xenograft derived from head and neck cancer in vivo in animal models. This review summarizes the evidence demonstrating potential use of curcumin as a single chemotherapeutic agent or in combination with other chemotherapeutic agents and radiation to minimize their toxicity in head and neck cancer. Although curcumin has been shown to be safe at doses of 8 g/d in both phase I and phase II clinical trials, its bioavailability is poor. Overcoming the poor bioavailability of curcumin in the near future would facilitate its clinical use.-
dc.languageengen_US
dc.publisherBentham Science Publishers Ltd. The Journal's web site is located at http://www.bentham.org/cmcaca-
dc.relation.ispartofAnti-Cancer Agents in Medicinal Chemistryen_US
dc.subjectChemotherapeutic agent-
dc.subjectCurcumin-
dc.subjectEpigenetics regulation-
dc.subjectHead and neck cancer-
dc.subjectMatrix Metalloproteinases-
dc.titleAnti-cancer effects of curcumin on head and neck cancersen_US
dc.typeArticleen_US
dc.identifier.emailGao, W: weigao@graduate.hku.hken_US
dc.identifier.emailChan, JYW: jywchan1@hku.hken_US
dc.identifier.emailWei, WI: hrmswwi@hku.hken_US
dc.identifier.emailWong, TS: wongtsa@hkucc.hku.hken_US
dc.identifier.authorityChan, YW=rp01314en_US
dc.identifier.authorityWei, WI=rp00323en_US
dc.identifier.authorityWong, STS=rp00478en_US
dc.identifier.doi10.2174/187152012803529736-
dc.identifier.pmid22583425-
dc.identifier.scopuseid_2-s2.0-84872224518-
dc.identifier.hkuros200710en_US
dc.identifier.volume12-
dc.identifier.issue9-
dc.identifier.spage1110-
dc.identifier.epage1116-
dc.identifier.isiWOS:000310055000010-
dc.publisher.placeNetherlands-

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