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Article: Epigenetic dysregulation in laryngeal squamous cell carcinoma
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TitleEpigenetic dysregulation in laryngeal squamous cell carcinoma
 
AuthorsWong, TS1
Gao, W1
Li, ZH1
Chan, JYW1
Ho, WK1
 
Issue Date2012
 
PublisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/jo/
 
CitationJournal Of Oncology, 2012, v. 2012, article no. 739461 [How to Cite?]
DOI: http://dx.doi.org/10.1155/2012/739461
 
AbstractLaryngeal carcinoma is a common head and neck cancer with poor prognosis. Patients with laryngeal carcinoma usually present late leading to the reduced treatment efficacy and high rate of recurrence. Despite the advance in the use of molecular markers for monitoring human cancers in the past decades, there are still no reliable markers for use to screen laryngeal carcinoma and follow the patients after treatment. Epigenetics emerged as an important field in understanding the biology of the human malignancies. Epigenetic alterations refer to the dysregulation of gene, which do not involve the alterations of the DNA sequence. Major epigenetic changes including methylation imbalance, histone modification, and small RNA dysregulation could play a role in the development of human malignancies. Global epigenetic change is now regarded as a molecular signature of cancer. The characteristics and behavior of a cancer could be predicted based on the specific epigenetic pattern. We here provide a review on the understanding of epigenetic dysregulation in laryngeal carcinoma. Further knowledge on the initiation and progression of laryngeal carcinoma at epigenetic level could promote the translation of the knowledge to clinical use. Copyright © 2012 Thian-Sze Wong et al.
 
ISSN1687-8450
2012 SCImago Journal Rankings: 0.568
 
DOIhttp://dx.doi.org/10.1155/2012/739461
 
PubMed Central IDPMC3356733
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorWong, TS
 
dc.contributor.authorGao, W
 
dc.contributor.authorLi, ZH
 
dc.contributor.authorChan, JYW
 
dc.contributor.authorHo, WK
 
dc.date.accessioned2012-07-16T09:51:01Z
 
dc.date.available2012-07-16T09:51:01Z
 
dc.date.issued2012
 
dc.description.abstractLaryngeal carcinoma is a common head and neck cancer with poor prognosis. Patients with laryngeal carcinoma usually present late leading to the reduced treatment efficacy and high rate of recurrence. Despite the advance in the use of molecular markers for monitoring human cancers in the past decades, there are still no reliable markers for use to screen laryngeal carcinoma and follow the patients after treatment. Epigenetics emerged as an important field in understanding the biology of the human malignancies. Epigenetic alterations refer to the dysregulation of gene, which do not involve the alterations of the DNA sequence. Major epigenetic changes including methylation imbalance, histone modification, and small RNA dysregulation could play a role in the development of human malignancies. Global epigenetic change is now regarded as a molecular signature of cancer. The characteristics and behavior of a cancer could be predicted based on the specific epigenetic pattern. We here provide a review on the understanding of epigenetic dysregulation in laryngeal carcinoma. Further knowledge on the initiation and progression of laryngeal carcinoma at epigenetic level could promote the translation of the knowledge to clinical use. Copyright © 2012 Thian-Sze Wong et al.
 
dc.description.naturepublished_or_final_version
 
dc.identifier.citationJournal Of Oncology, 2012, v. 2012, article no. 739461 [How to Cite?]
DOI: http://dx.doi.org/10.1155/2012/739461
 
dc.identifier.doihttp://dx.doi.org/10.1155/2012/739461
 
dc.identifier.hkuros200706
 
dc.identifier.issn1687-8450
2012 SCImago Journal Rankings: 0.568
 
dc.identifier.pmcidPMC3356733
 
dc.identifier.pmid22645613
 
dc.identifier.scopuseid_2-s2.0-84862282178
 
dc.identifier.urihttp://hdl.handle.net/10722/152865
 
dc.languageeng
 
dc.publisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/jo/
 
dc.publisher.placeUnited States
 
dc.relation.ispartofJournal of Oncology
 
dc.relation.referencesReferences in Scopus
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
 
dc.titleEpigenetic dysregulation in laryngeal squamous cell carcinoma
 
dc.typeArticle
 
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<description.abstract>Laryngeal carcinoma is a common head and neck cancer with poor prognosis. Patients with laryngeal carcinoma usually present late leading to the reduced treatment efficacy and high rate of recurrence. Despite the advance in the use of molecular markers for monitoring human cancers in the past decades, there are still no reliable markers for use to screen laryngeal carcinoma and follow the patients after treatment. Epigenetics emerged as an important field in understanding the biology of the human malignancies. Epigenetic alterations refer to the dysregulation of gene, which do not involve the alterations of the DNA sequence. Major epigenetic changes including methylation imbalance, histone modification, and small RNA dysregulation could play a role in the development of human malignancies. Global epigenetic change is now regarded as a molecular signature of cancer. The characteristics and behavior of a cancer could be predicted based on the specific epigenetic pattern. We here provide a review on the understanding of epigenetic dysregulation in laryngeal carcinoma. Further knowledge on the initiation and progression of laryngeal carcinoma at epigenetic level could promote the translation of the knowledge to clinical use. Copyright &#169; 2012 Thian-Sze Wong et al.</description.abstract>
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Author Affiliations
  1. The University of Hong Kong