Article: Epigenetic dysregulation in laryngeal squamous cell carcinoma

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Publisher Website: 10.1155/2012/739461
Scopus: eid_2-s2.0-84862282178
PMID: 22645613

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Title	Epigenetic dysregulation in laryngeal squamous cell carcinoma
Authors	Wong, TS Gao, W1 Li, ZH1 Chan, JYW1 Ho, WK1
Issue Date	2012
Publisher	Hindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/jo/
Citation	Journal Of Oncology, 2012, v. 2012, article no. 739461 [How to Cite?] DOI: http://dx.doi.org/10.1155/2012/739461
Abstract	Laryngeal carcinoma is a common head and neck cancer with poor prognosis. Patients with laryngeal carcinoma usually present late leading to the reduced treatment efficacy and high rate of recurrence. Despite the advance in the use of molecular markers for monitoring human cancers in the past decades, there are still no reliable markers for use to screen laryngeal carcinoma and follow the patients after treatment. Epigenetics emerged as an important field in understanding the biology of the human malignancies. Epigenetic alterations refer to the dysregulation of gene, which do not involve the alterations of the DNA sequence. Major epigenetic changes including methylation imbalance, histone modification, and small RNA dysregulation could play a role in the development of human malignancies. Global epigenetic change is now regarded as a molecular signature of cancer. The characteristics and behavior of a cancer could be predicted based on the specific epigenetic pattern. We here provide a review on the understanding of epigenetic dysregulation in laryngeal carcinoma. Further knowledge on the initiation and progression of laryngeal carcinoma at epigenetic level could promote the translation of the knowledge to clinical use. Copyright © 2012 Thian-Sze Wong et al.
ISSN	1687-8450 2011 SCImago Journal Rankings: 0.164
DOI	http://dx.doi.org/10.1155/2012/739461
PubMed Central ID	PMC3356733
References	References in Scopus

DC Field	Value
dc.contributor.author	Wong, TS
dc.contributor.author	Gao, W
dc.contributor.author	Li, ZH
dc.contributor.author	Chan, JYW
dc.contributor.author	Ho, WK
dc.date.accessioned	2012-07-16T09:51:01Z
dc.date.available	2012-07-16T09:51:01Z
dc.date.issued	2012
dc.description.abstract	Laryngeal carcinoma is a common head and neck cancer with poor prognosis. Patients with laryngeal carcinoma usually present late leading to the reduced treatment efficacy and high rate of recurrence. Despite the advance in the use of molecular markers for monitoring human cancers in the past decades, there are still no reliable markers for use to screen laryngeal carcinoma and follow the patients after treatment. Epigenetics emerged as an important field in understanding the biology of the human malignancies. Epigenetic alterations refer to the dysregulation of gene, which do not involve the alterations of the DNA sequence. Major epigenetic changes including methylation imbalance, histone modification, and small RNA dysregulation could play a role in the development of human malignancies. Global epigenetic change is now regarded as a molecular signature of cancer. The characteristics and behavior of a cancer could be predicted based on the specific epigenetic pattern. We here provide a review on the understanding of epigenetic dysregulation in laryngeal carcinoma. Further knowledge on the initiation and progression of laryngeal carcinoma at epigenetic level could promote the translation of the knowledge to clinical use. Copyright © 2012 Thian-Sze Wong et al.
dc.description.nature	published_or_final_version
dc.identifier.citation	Journal Of Oncology, 2012, v. 2012, article no. 739461 [How to Cite?] DOI: http://dx.doi.org/10.1155/2012/739461
dc.identifier.doi	http://dx.doi.org/10.1155/2012/739461
dc.identifier.hkuros	200706
dc.identifier.issn	1687-8450 2011 SCImago Journal Rankings: 0.164
dc.identifier.pmcid	PMC3356733
dc.identifier.pmid	22645613
dc.identifier.scopus	eid_2-s2.0-84862282178
dc.identifier.uri	http://hdl.handle.net/10722/152865
dc.language	eng
dc.publisher	Hindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/jo/
dc.publisher.place	United States
dc.relation.ispartof	Journal of Oncology
dc.relation.references	References in Scopus
dc.rights	Creative Commons: Attribution 3.0 Hong Kong License
dc.title	Epigenetic dysregulation in laryngeal squamous cell carcinoma
dc.type	Article

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Author Affiliations

The University of Hong Kong