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Article: Epigenetic dysregulation in laryngeal squamous cell carcinoma

TitleEpigenetic dysregulation in laryngeal squamous cell carcinoma
Authors
Issue Date2012
PublisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/jo/
Citation
Journal Of Oncology, 2012, v. 2012, article no. 739461 How to Cite?
Abstract
Laryngeal carcinoma is a common head and neck cancer with poor prognosis. Patients with laryngeal carcinoma usually present late leading to the reduced treatment efficacy and high rate of recurrence. Despite the advance in the use of molecular markers for monitoring human cancers in the past decades, there are still no reliable markers for use to screen laryngeal carcinoma and follow the patients after treatment. Epigenetics emerged as an important field in understanding the biology of the human malignancies. Epigenetic alterations refer to the dysregulation of gene, which do not involve the alterations of the DNA sequence. Major epigenetic changes including methylation imbalance, histone modification, and small RNA dysregulation could play a role in the development of human malignancies. Global epigenetic change is now regarded as a molecular signature of cancer. The characteristics and behavior of a cancer could be predicted based on the specific epigenetic pattern. We here provide a review on the understanding of epigenetic dysregulation in laryngeal carcinoma. Further knowledge on the initiation and progression of laryngeal carcinoma at epigenetic level could promote the translation of the knowledge to clinical use. Copyright © 2012 Thian-Sze Wong et al.
Persistent Identifierhttp://hdl.handle.net/10722/152865
ISSN
PubMed Central ID
References

 

DC FieldValueLanguage
dc.contributor.authorWong, TSen_HK
dc.contributor.authorGao, Wen_HK
dc.contributor.authorLi, ZHen_HK
dc.contributor.authorChan, JYWen_HK
dc.contributor.authorHo, WKen_HK
dc.date.accessioned2012-07-16T09:51:01Z-
dc.date.available2012-07-16T09:51:01Z-
dc.date.issued2012en_HK
dc.identifier.citationJournal Of Oncology, 2012, v. 2012, article no. 739461en_HK
dc.identifier.issn1687-8450en_HK
dc.identifier.urihttp://hdl.handle.net/10722/152865-
dc.description.abstractLaryngeal carcinoma is a common head and neck cancer with poor prognosis. Patients with laryngeal carcinoma usually present late leading to the reduced treatment efficacy and high rate of recurrence. Despite the advance in the use of molecular markers for monitoring human cancers in the past decades, there are still no reliable markers for use to screen laryngeal carcinoma and follow the patients after treatment. Epigenetics emerged as an important field in understanding the biology of the human malignancies. Epigenetic alterations refer to the dysregulation of gene, which do not involve the alterations of the DNA sequence. Major epigenetic changes including methylation imbalance, histone modification, and small RNA dysregulation could play a role in the development of human malignancies. Global epigenetic change is now regarded as a molecular signature of cancer. The characteristics and behavior of a cancer could be predicted based on the specific epigenetic pattern. We here provide a review on the understanding of epigenetic dysregulation in laryngeal carcinoma. Further knowledge on the initiation and progression of laryngeal carcinoma at epigenetic level could promote the translation of the knowledge to clinical use. Copyright © 2012 Thian-Sze Wong et al.en_HK
dc.languageengen_US
dc.publisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/jo/en_HK
dc.relation.ispartofJournal of Oncologyen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleEpigenetic dysregulation in laryngeal squamous cell carcinomaen_HK
dc.typeArticleen_HK
dc.identifier.emailChan, JYW: jywchan1@hku.hken_HK
dc.identifier.authorityChan, JYW=rp01314en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1155/2012/739461en_HK
dc.identifier.pmid22645613-
dc.identifier.pmcidPMC3356733-
dc.identifier.scopuseid_2-s2.0-84862282178en_HK
dc.identifier.hkuros200706en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84862282178&selection=ref&src=s&origin=recordpageen_HK
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridWong, TS=55252917500en_HK
dc.identifier.scopusauthoridGao, W=55252457300en_HK
dc.identifier.scopusauthoridLi, ZH=55252953400en_HK
dc.identifier.scopusauthoridChan, JYW=27171772200en_HK
dc.identifier.scopusauthoridHo, WK=7402968844en_HK

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