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Article: Current management strategy of hypopharyngeal carcinoma

TitleCurrent management strategy of hypopharyngeal carcinoma
Authors
KeywordsCarcinoma of hypopharynx
Chemoradiotherapy
Pharyngectomy
TORS
Issue Date2013
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/anl
Citation
Auris Nasus Larynx, 2013, v. 40 n. 1, p. 2-6 How to Cite?
AbstractOBJECTIVES: Squamous cell carcinoma (SCC) of the hypopharynx represents a distinct clinical entity among other cancers of the head and neck region. Despite recent advances in chemoradiotherapy, surgery remains the preferred therapeutic option for locally advanced disease and salvage for failure after chemo-radiotherapy. In this article, several aspects of surgical and non-surgical approaches in the management of hypopharyngeal cancer are discussed. METHODS: A search in pubmed was made for publications with regard to the management of hypopharyngeal carcinoma. RESULTS: In early-staged hypopharyngeal cancer, the overall and disease-specific survival rates after organ-preserving radiotherapy is comparable to that after surgery. However, for advanced staged disease, the results initial surgery with post-operative adjuvant radiotherapy was superior to chemoradiotherapy alone. The incidence of occult nodal metastasis is found to be more than 20%. Selective neck dissection removing cervical lymph node level II-IV is the procedure of choice for patients with clinically N0 neck. Contralateral nodal clearance may also be considered in tumors involving the medial wall of the pyriform recess, post-crioid region or the posterior wall, and those with ipsilateral palpable nodal metastasis and clinical stage IV disease. Transoral robotic surgery (TORS) has the potential value as the minimally invasive procedure for the management of carcinoma of the hypopharynx. CONCLUSIONS: The treatment strategy for carcinoma of the hypopharynx has been evolving with time. Organ preserving chemoradiotherapy has been the treatment of choice for early stage disease, with surgical resection and reconstruction reserved for advanced and recurrent tumors.
Persistent Identifierhttp://hdl.handle.net/10722/152864
ISSN
2015 Impact Factor: 1.038
2015 SCImago Journal Rankings: 0.688
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChan, JYWen_HK
dc.contributor.authorWei, WIen_HK
dc.date.accessioned2012-07-16T09:51:01Z-
dc.date.available2012-07-16T09:51:01Z-
dc.date.issued2013en_HK
dc.identifier.citationAuris Nasus Larynx, 2013, v. 40 n. 1, p. 2-6en_HK
dc.identifier.issn0385-8146en_HK
dc.identifier.urihttp://hdl.handle.net/10722/152864-
dc.description.abstractOBJECTIVES: Squamous cell carcinoma (SCC) of the hypopharynx represents a distinct clinical entity among other cancers of the head and neck region. Despite recent advances in chemoradiotherapy, surgery remains the preferred therapeutic option for locally advanced disease and salvage for failure after chemo-radiotherapy. In this article, several aspects of surgical and non-surgical approaches in the management of hypopharyngeal cancer are discussed. METHODS: A search in pubmed was made for publications with regard to the management of hypopharyngeal carcinoma. RESULTS: In early-staged hypopharyngeal cancer, the overall and disease-specific survival rates after organ-preserving radiotherapy is comparable to that after surgery. However, for advanced staged disease, the results initial surgery with post-operative adjuvant radiotherapy was superior to chemoradiotherapy alone. The incidence of occult nodal metastasis is found to be more than 20%. Selective neck dissection removing cervical lymph node level II-IV is the procedure of choice for patients with clinically N0 neck. Contralateral nodal clearance may also be considered in tumors involving the medial wall of the pyriform recess, post-crioid region or the posterior wall, and those with ipsilateral palpable nodal metastasis and clinical stage IV disease. Transoral robotic surgery (TORS) has the potential value as the minimally invasive procedure for the management of carcinoma of the hypopharynx. CONCLUSIONS: The treatment strategy for carcinoma of the hypopharynx has been evolving with time. Organ preserving chemoradiotherapy has been the treatment of choice for early stage disease, with surgical resection and reconstruction reserved for advanced and recurrent tumors.en_HK
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/anlen_HK
dc.relation.ispartofAuris Nasus Larynxen_HK
dc.subjectCarcinoma of hypopharynxen_HK
dc.subjectChemoradiotherapyen_HK
dc.subjectPharyngectomyen_HK
dc.subjectTORSen_HK
dc.titleCurrent management strategy of hypopharyngeal carcinomaen_HK
dc.typeArticleen_HK
dc.identifier.emailChan, JYW: jywchan1@hku.hken_HK
dc.identifier.emailWei, WI: hrmswwi@hku.hk-
dc.identifier.authorityChan, JYW=rp01314en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.anl.2011.11.009en_HK
dc.identifier.pmid22709574-
dc.identifier.scopuseid_2-s2.0-84873086722en_HK
dc.identifier.hkuros200704en_US
dc.identifier.isiWOS:000315249700002-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridWei, WI=55251021200en_HK
dc.identifier.scopusauthoridChan, JYW=27171772200en_HK
dc.identifier.citeulike10813160-

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