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Article: Central auditory nervous system dysfunction in infants with non-syndromic cleft lip and/or palate

TitleCentral auditory nervous system dysfunction in infants with non-syndromic cleft lip and/or palate
Authors
KeywordsAuditory evoked potentials
Auditory pathway
Cleft lip and palate
Event related potential
Hearing impairment
Issue Date2012
PublisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ijporl
Citation
International Journal Of Pediatric Otorhinolaryngology, 2012, v. 76 n. 1, p. 82-89 How to Cite?
AbstractObjective: Peripheral hearing loss has been commonly reported in children with non-syndromic cleft lip and/or palate (NSCLP) but few studies have provided information about central auditory nervous system (CANS) functioning for this group. The main objective of this study was to explore CANS functioning in infants with NSCLP through analysis of auditory evoked potentials (AEPs). Methods: AEPs including auditory brainstem response (ABR), middle latency response (MLR), and mismatch negativity (MMN) recordings were conducted in 34 infants of Chinese ethnicity with NSCLP and an equivalent number of normal controls. Results: There was no significant difference in ABR (all measurements, including wave I, III, V latencies, I-V inter-wave latency, and wave V amplitude), or MLR (recordable components, Na, Pa latencies, and Na-Pa amplitude) findings between the two groups. However, infants with NSCLP had a significantly smaller MMN response than their normal controls, using MMN strength as the measurement. Conclusions: Significant abnormal auditory evoked potential findings at the cortical level suggest that infants with NSCLP may be at risk of central auditory discrimination dysfunction. Further effort is needed to determine auditory processing abilities in infants with NSCLP. © 2011 Elsevier Ireland Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/152853
ISSN
2015 Impact Factor: 1.125
2015 SCImago Journal Rankings: 0.649
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYang, FFen_HK
dc.contributor.authorMcPherson, Ben_HK
dc.contributor.authorShu, Hen_HK
dc.contributor.authorXiao, Yen_HK
dc.date.accessioned2012-07-16T09:50:31Z-
dc.date.available2012-07-16T09:50:31Z-
dc.date.issued2012en_HK
dc.identifier.citationInternational Journal Of Pediatric Otorhinolaryngology, 2012, v. 76 n. 1, p. 82-89en_HK
dc.identifier.issn0165-5876en_HK
dc.identifier.urihttp://hdl.handle.net/10722/152853-
dc.description.abstractObjective: Peripheral hearing loss has been commonly reported in children with non-syndromic cleft lip and/or palate (NSCLP) but few studies have provided information about central auditory nervous system (CANS) functioning for this group. The main objective of this study was to explore CANS functioning in infants with NSCLP through analysis of auditory evoked potentials (AEPs). Methods: AEPs including auditory brainstem response (ABR), middle latency response (MLR), and mismatch negativity (MMN) recordings were conducted in 34 infants of Chinese ethnicity with NSCLP and an equivalent number of normal controls. Results: There was no significant difference in ABR (all measurements, including wave I, III, V latencies, I-V inter-wave latency, and wave V amplitude), or MLR (recordable components, Na, Pa latencies, and Na-Pa amplitude) findings between the two groups. However, infants with NSCLP had a significantly smaller MMN response than their normal controls, using MMN strength as the measurement. Conclusions: Significant abnormal auditory evoked potential findings at the cortical level suggest that infants with NSCLP may be at risk of central auditory discrimination dysfunction. Further effort is needed to determine auditory processing abilities in infants with NSCLP. © 2011 Elsevier Ireland Ltd.en_HK
dc.languageengen_US
dc.publisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ijporlen_HK
dc.relation.ispartofInternational Journal of Pediatric Otorhinolaryngologyen_HK
dc.subjectAuditory evoked potentialsen_HK
dc.subjectAuditory pathwayen_HK
dc.subjectCleft lip and palateen_HK
dc.subjectEvent related potentialen_HK
dc.subjectHearing impairmenten_HK
dc.subject.meshAge Distribution-
dc.subject.meshAuditory Diseases, Central - diagnosis - epidemiology - etiology-
dc.subject.meshCleft Lip - diagnosis - epidemiology-
dc.subject.meshEvoked Potentials, Auditory, Brain Stem - physiology-
dc.subject.meshHearing Loss, Sensorineural - diagnosis - epidemiology-
dc.titleCentral auditory nervous system dysfunction in infants with non-syndromic cleft lip and/or palateen_HK
dc.typeArticleen_HK
dc.identifier.emailMcPherson, B: dbmcpher@hkucc.hku.hken_HK
dc.identifier.authorityMcPherson, B=rp00937en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ijporl.2011.10.005en_HK
dc.identifier.pmid22079239-
dc.identifier.scopuseid_2-s2.0-84855532384en_HK
dc.identifier.hkuros201905en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84855532384&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume76en_HK
dc.identifier.issue1en_HK
dc.identifier.spage82en_HK
dc.identifier.epage89en_HK
dc.identifier.eissn1872-8464-
dc.identifier.isiWOS:000301008000018-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridYang, FF=54384481800en_HK
dc.identifier.scopusauthoridMcPherson, B=7006800770en_HK
dc.identifier.scopusauthoridShu, H=54384241800en_HK
dc.identifier.scopusauthoridXiao, Y=54384641500en_HK
dc.identifier.citeulike10030531-

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