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Article: Heritability of hallucinations in adolescent twins

TitleHeritability of hallucinations in adolescent twins
Authors
KeywordsEndophenotype
Environment
Genetics
Model-fitting
Psychopathology
Issue Date2012
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/psychres
Citation
Psychiatry Research, 2012, v. 199 n. 2, p. 98-101 How to Cite?
AbstractHallucinations are common in normal individuals and patients with schizophrenia and other psychotic disorders. Traditionally psycho-social approaches have emphasized the importance of environmental factors that contribute to variation of hallucinations. Using the Launay-Slade Hallucination Scale-Revised (LSHS-R), we investigated genetic and environmental influences on hallucinations in 598 pairs of healthy South Korean adolescent twins. Parameter estimates in the best-fitting model indicated that additive genetic and individual specific environmental factors for the LSHS-R were 33% (95% CI: 23-42%) and 67% (95% CI: 60-77%), respectively. There was no evidence for sex-specific genes for hallucinations. The magnitudes of genetic and environmental influences on hallucinations were similar in males and females. These results have implications in future molecular genetic studies that search for genes for hallucinations.
Persistent Identifierhttp://hdl.handle.net/10722/152819
ISSN
2015 Impact Factor: 2.466
2015 SCImago Journal Rankings: 1.235
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHur, YMen_HK
dc.contributor.authorCherny, SSen_HK
dc.contributor.authorSham, PCen_HK
dc.date.accessioned2012-07-16T09:49:39Z-
dc.date.available2012-07-16T09:49:39Z-
dc.date.issued2012en_HK
dc.identifier.citationPsychiatry Research, 2012, v. 199 n. 2, p. 98-101en_HK
dc.identifier.issn0165-1781en_HK
dc.identifier.urihttp://hdl.handle.net/10722/152819-
dc.description.abstractHallucinations are common in normal individuals and patients with schizophrenia and other psychotic disorders. Traditionally psycho-social approaches have emphasized the importance of environmental factors that contribute to variation of hallucinations. Using the Launay-Slade Hallucination Scale-Revised (LSHS-R), we investigated genetic and environmental influences on hallucinations in 598 pairs of healthy South Korean adolescent twins. Parameter estimates in the best-fitting model indicated that additive genetic and individual specific environmental factors for the LSHS-R were 33% (95% CI: 23-42%) and 67% (95% CI: 60-77%), respectively. There was no evidence for sex-specific genes for hallucinations. The magnitudes of genetic and environmental influences on hallucinations were similar in males and females. These results have implications in future molecular genetic studies that search for genes for hallucinations.en_HK
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/psychresen_HK
dc.relation.ispartofPsychiatry Researchen_HK
dc.subjectEndophenotypeen_HK
dc.subjectEnvironmenten_HK
dc.subjectGeneticsen_HK
dc.subjectModel-fittingen_HK
dc.subjectPsychopathologyen_HK
dc.titleHeritability of hallucinations in adolescent twinsen_HK
dc.typeArticleen_HK
dc.identifier.emailHur, YM: ymhur@mokpo.ac.kren_HK
dc.identifier.emailCherny, SS: cherny@hku.hken_HK
dc.identifier.emailSham, PC: pcsham@hku.hk-
dc.identifier.authorityCherny, SS=rp00232en_HK
dc.identifier.authoritySham, PC=rp00459en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.psychres.2012.04.024en_HK
dc.identifier.pmid22578404-
dc.identifier.scopuseid_2-s2.0-84869167805en_HK
dc.identifier.hkuros200602en_US
dc.identifier.isiWOS:000312510700004-
dc.publisher.placeIrelanden_HK
dc.identifier.scopusauthoridSham, PC=34573429300en_HK
dc.identifier.scopusauthoridCherny, SS=7004670001en_HK
dc.identifier.scopusauthoridHur, YM=7006335989en_HK
dc.identifier.citeulike10661212-

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