Article: One-year follow up of melamine-associated renal stones in Sichuan and Hong Kong

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TitleOne-year follow up of melamine-associated renal stones in Sichuan and Hong Kong
AuthorsTu, WW2 3 6
Yang, H4
Luo, H4
Shi, H4
Wong, WHS6
Lau, WWS6
Yip, C9
Yuen, SF8
Chim, S6
Chan, WKY7
Wong, SN5
Ho, CS1
Feng, T2 3
Lam, K6
Li, H2 3
Lee, PPW6
Mao, M4
Lau, YL6
KeywordsCytokines
Interleukin-8
Melamine
Milk
Renal stones
Issue Date2012
PublisherMedcom Limited. The Journal's web site is located at http://www.hkjpaed.org/index.asp
CitationHong Kong Journal Of Paediatrics, 2012, v. 17 n. 1, p. 12-23 [How to Cite?]
AbstractBackground: An outbreak of melamine-associated renal stones occurred in mainland China in 2008, which led to large scale community screening of renal stones in Hong Kong. We hypothesised Hong Kong children screened positive did not suffer from melamine-associated renal stones. Methods: This one-year follow-up study compared the clinical features, renal ultrasound findings, and urinary interleukin 8 (IL-8) and monocyte chemoattractant protein 1 (MCP-1) to urinary creatinine ratios between 44 Sichuan children admitted to hospital for melamine-associated renal stones and 22 Hong Kong children screened positive with renal stones. Results: The mean age (±SD) in months of the Sichuan children (25.7±23.8) was significantly lower than that of Hong Kong children (75.0±42.1, p<0.0001). The melamine concentration in the milk consumed by the Sichuan children was significantly higher than that by Hong Kong children. All 44 Sichuan children and only 15 of the 22 Hong Kong children consumed melaminetainted milk product (MTMP). All except one of the 15 Hong Kong children had their daily melamineintake below the WHO tolerable daily intake of 0.2 mg melamine/Kg body weight. At diagnosis, the median number of stones and the mean largest stone size in the Sichuan children (4, 6.3 mm) were significantly higher than that in Hong Kong children (1, 3.8 mm, p<0.01). By 12 months follow-up, 28% and 48% of the Sichuan and Hong Kong children still had renal stones respectively. Urinary IL-8/creatinine ratio was significantly higher in Sichuan children with stones than other groups at 6 and 9 months followup. By 12 months follow-up, no such difference was observed among any groups. The above findings did not differ significantly whether the comparison with the Sichuan children was with the whole cohort of 22 Hong Kong children or the 15 who had consumed MTMP. In contrast, the 2 groups of Hong Kong children with and without MTMP consumption were similar in their demographics and clinical features. Conclusions: Hong Kong children had significantly different clinical features including MTMP consumption as compared to Sichuan children, suggesting Hong Kong children did not suffer from melamine-associated renal stones.
DescriptionFulltext link: http://www.hkjpaed.org/pdf/2012;17;12-23.pdf
ISSN1013-9923
2011 Impact Factor: 0.027
2011 SCImago Journal Rankings: 0.029
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorTu, WW
dc.contributor.authorYang, H
dc.contributor.authorLuo, H
dc.contributor.authorShi, H
dc.contributor.authorWong, WHS
dc.contributor.authorLau, WWS
dc.contributor.authorYip, C
dc.contributor.authorYuen, SF
dc.contributor.authorChim, S
dc.contributor.authorChan, WKY
dc.contributor.authorWong, SN
dc.contributor.authorHo, CS
dc.contributor.authorFeng, T
dc.contributor.authorLam, K
dc.contributor.authorLi, H
dc.contributor.authorLee, PPW
dc.contributor.authorMao, M
dc.contributor.authorLau, YL
dc.date.accessioned2012-07-16T09:48:36Z
dc.date.available2012-07-16T09:48:36Z
dc.date.issued2012
dc.description.abstractBackground: An outbreak of melamine-associated renal stones occurred in mainland China in 2008, which led to large scale community screening of renal stones in Hong Kong. We hypothesised Hong Kong children screened positive did not suffer from melamine-associated renal stones. Methods: This one-year follow-up study compared the clinical features, renal ultrasound findings, and urinary interleukin 8 (IL-8) and monocyte chemoattractant protein 1 (MCP-1) to urinary creatinine ratios between 44 Sichuan children admitted to hospital for melamine-associated renal stones and 22 Hong Kong children screened positive with renal stones. Results: The mean age (±SD) in months of the Sichuan children (25.7±23.8) was significantly lower than that of Hong Kong children (75.0±42.1, p<0.0001). The melamine concentration in the milk consumed by the Sichuan children was significantly higher than that by Hong Kong children. All 44 Sichuan children and only 15 of the 22 Hong Kong children consumed melaminetainted milk product (MTMP). All except one of the 15 Hong Kong children had their daily melamineintake below the WHO tolerable daily intake of 0.2 mg melamine/Kg body weight. At diagnosis, the median number of stones and the mean largest stone size in the Sichuan children (4, 6.3 mm) were significantly higher than that in Hong Kong children (1, 3.8 mm, p<0.01). By 12 months follow-up, 28% and 48% of the Sichuan and Hong Kong children still had renal stones respectively. Urinary IL-8/creatinine ratio was significantly higher in Sichuan children with stones than other groups at 6 and 9 months followup. By 12 months follow-up, no such difference was observed among any groups. The above findings did not differ significantly whether the comparison with the Sichuan children was with the whole cohort of 22 Hong Kong children or the 15 who had consumed MTMP. In contrast, the 2 groups of Hong Kong children with and without MTMP consumption were similar in their demographics and clinical features. Conclusions: Hong Kong children had significantly different clinical features including MTMP consumption as compared to Sichuan children, suggesting Hong Kong children did not suffer from melamine-associated renal stones.
dc.description.natureLink_to_subscribed_fulltext
dc.descriptionFulltext link: http://www.hkjpaed.org/pdf/2012;17;12-23.pdf
dc.identifier.citationHong Kong Journal Of Paediatrics, 2012, v. 17 n. 1, p. 12-23 [How to Cite?]
dc.identifier.epage23
dc.identifier.hkuros200724
dc.identifier.issn1013-9923
2011 Impact Factor: 0.027
2011 SCImago Journal Rankings: 0.029
dc.identifier.issue1
dc.identifier.scopuseid_2-s2.0-84863064236
dc.identifier.spage12
dc.identifier.urihttp://hdl.handle.net/10722/152791
dc.identifier.volume17
dc.languageeng
dc.publisherMedcom Limited. The Journal's web site is located at http://www.hkjpaed.org/index.asp
dc.publisher.placeHong Kong
dc.relation.ispartofHong Kong Journal of Paediatrics
dc.relation.referencesReferences in Scopus
dc.subjectCytokines
dc.subjectInterleukin-8
dc.subjectMelamine
dc.subjectMilk
dc.subjectRenal stones
dc.titleOne-year follow up of melamine-associated renal stones in Sichuan and Hong Kong
dc.typeArticle
Author Affiliations
  1. Kwong Wah Hospital
  2. The University of Hong Kong Li Ka Shing Faculty of Medicine
  3. European Commission Joint Research Centre
  4. West China Hospital
  5. Tuen Mun Hospital
  6. The University of Hong Kong
  7. Queen Elizabeth Hospital Hong Kong
  8. Pamela Youde Nethersole Eastern Hospital
  9. United Christian Hospital Hong Kong