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Article: One-year follow up of melamine-associated renal stones in Sichuan and Hong Kong

TitleOne-year follow up of melamine-associated renal stones in Sichuan and Hong Kong
Authors
KeywordsCytokines
Interleukin-8
Melamine
Milk
Renal stones
Issue Date2012
PublisherMedcom Limited. The Journal's web site is located at http://www.hkjpaed.org/index.asp
Citation
Hong Kong Journal Of Paediatrics, 2012, v. 17 n. 1, p. 12-23 How to Cite?
AbstractBackground: An outbreak of melamine-associated renal stones occurred in mainland China in 2008, which led to large scale community screening of renal stones in Hong Kong. We hypothesised Hong Kong children screened positive did not suffer from melamine-associated renal stones. Methods: This one-year follow-up study compared the clinical features, renal ultrasound findings, and urinary interleukin 8 (IL-8) and monocyte chemoattractant protein 1 (MCP-1) to urinary creatinine ratios between 44 Sichuan children admitted to hospital for melamine-associated renal stones and 22 Hong Kong children screened positive with renal stones. Results: The mean age (±SD) in months of the Sichuan children (25.7±23.8) was significantly lower than that of Hong Kong children (75.0±42.1, p<0.0001). The melamine concentration in the milk consumed by the Sichuan children was significantly higher than that by Hong Kong children. All 44 Sichuan children and only 15 of the 22 Hong Kong children consumed melaminetainted milk product (MTMP). All except one of the 15 Hong Kong children had their daily melamineintake below the WHO tolerable daily intake of 0.2 mg melamine/Kg body weight. At diagnosis, the median number of stones and the mean largest stone size in the Sichuan children (4, 6.3 mm) were significantly higher than that in Hong Kong children (1, 3.8 mm, p<0.01). By 12 months follow-up, 28% and 48% of the Sichuan and Hong Kong children still had renal stones respectively. Urinary IL-8/creatinine ratio was significantly higher in Sichuan children with stones than other groups at 6 and 9 months followup. By 12 months follow-up, no such difference was observed among any groups. The above findings did not differ significantly whether the comparison with the Sichuan children was with the whole cohort of 22 Hong Kong children or the 15 who had consumed MTMP. In contrast, the 2 groups of Hong Kong children with and without MTMP consumption were similar in their demographics and clinical features. Conclusions: Hong Kong children had significantly different clinical features including MTMP consumption as compared to Sichuan children, suggesting Hong Kong children did not suffer from melamine-associated renal stones.
Persistent Identifierhttp://hdl.handle.net/10722/152791
ISSN
2014 Impact Factor: 0.133
2013 SCImago Journal Rankings: 0.126
References

 

DC FieldValueLanguage
dc.contributor.authorTu, WWen_HK
dc.contributor.authorYang, Hen_HK
dc.contributor.authorLuo, Hen_HK
dc.contributor.authorShi, Hen_HK
dc.contributor.authorWong, WHSen_HK
dc.contributor.authorLau, WWSen_HK
dc.contributor.authorYip, Cen_HK
dc.contributor.authorYuen, SFen_HK
dc.contributor.authorChim, Sen_HK
dc.contributor.authorChan, WKYen_HK
dc.contributor.authorWong, SNen_HK
dc.contributor.authorHo, CSen_HK
dc.contributor.authorFeng, Ten_HK
dc.contributor.authorLam, Ken_HK
dc.contributor.authorLi, Hen_HK
dc.contributor.authorLee, PPWen_HK
dc.contributor.authorMao, Men_HK
dc.contributor.authorLau, YLen_HK
dc.date.accessioned2012-07-16T09:48:36Z-
dc.date.available2012-07-16T09:48:36Z-
dc.date.issued2012en_HK
dc.identifier.citationHong Kong Journal Of Paediatrics, 2012, v. 17 n. 1, p. 12-23en_HK
dc.identifier.issn1013-9923en_HK
dc.identifier.urihttp://hdl.handle.net/10722/152791-
dc.description.abstractBackground: An outbreak of melamine-associated renal stones occurred in mainland China in 2008, which led to large scale community screening of renal stones in Hong Kong. We hypothesised Hong Kong children screened positive did not suffer from melamine-associated renal stones. Methods: This one-year follow-up study compared the clinical features, renal ultrasound findings, and urinary interleukin 8 (IL-8) and monocyte chemoattractant protein 1 (MCP-1) to urinary creatinine ratios between 44 Sichuan children admitted to hospital for melamine-associated renal stones and 22 Hong Kong children screened positive with renal stones. Results: The mean age (±SD) in months of the Sichuan children (25.7±23.8) was significantly lower than that of Hong Kong children (75.0±42.1, p<0.0001). The melamine concentration in the milk consumed by the Sichuan children was significantly higher than that by Hong Kong children. All 44 Sichuan children and only 15 of the 22 Hong Kong children consumed melaminetainted milk product (MTMP). All except one of the 15 Hong Kong children had their daily melamineintake below the WHO tolerable daily intake of 0.2 mg melamine/Kg body weight. At diagnosis, the median number of stones and the mean largest stone size in the Sichuan children (4, 6.3 mm) were significantly higher than that in Hong Kong children (1, 3.8 mm, p<0.01). By 12 months follow-up, 28% and 48% of the Sichuan and Hong Kong children still had renal stones respectively. Urinary IL-8/creatinine ratio was significantly higher in Sichuan children with stones than other groups at 6 and 9 months followup. By 12 months follow-up, no such difference was observed among any groups. The above findings did not differ significantly whether the comparison with the Sichuan children was with the whole cohort of 22 Hong Kong children or the 15 who had consumed MTMP. In contrast, the 2 groups of Hong Kong children with and without MTMP consumption were similar in their demographics and clinical features. Conclusions: Hong Kong children had significantly different clinical features including MTMP consumption as compared to Sichuan children, suggesting Hong Kong children did not suffer from melamine-associated renal stones.en_HK
dc.languageengen_US
dc.publisherMedcom Limited. The Journal's web site is located at http://www.hkjpaed.org/index.aspen_HK
dc.relation.ispartofHong Kong Journal of Paediatricsen_HK
dc.subjectCytokinesen_HK
dc.subjectInterleukin-8en_HK
dc.subjectMelamineen_HK
dc.subjectMilken_HK
dc.subjectRenal stonesen_HK
dc.titleOne-year follow up of melamine-associated renal stones in Sichuan and Hong Kongen_HK
dc.typeArticleen_HK
dc.identifier.emailLau, YL:lauylung@hkucc.hku.hken_HK
dc.identifier.authorityLau, YL=rp00361en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.scopuseid_2-s2.0-84863064236en_HK
dc.identifier.hkuros200724en_US
dc.identifier.hkuros225554-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84863064236&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume17en_HK
dc.identifier.issue1en_HK
dc.identifier.spage12en_HK
dc.identifier.epage23en_HK
dc.publisher.placeHong Kongen_HK
dc.identifier.scopusauthoridTu, WW=55267176800en_HK
dc.identifier.scopusauthoridYang, H=55268872700en_HK
dc.identifier.scopusauthoridLuo, H=55267057600en_HK
dc.identifier.scopusauthoridShi, H=55267056300en_HK
dc.identifier.scopusauthoridWong, WHS=55267818900en_HK
dc.identifier.scopusauthoridLau, WWS=55268320900en_HK
dc.identifier.scopusauthoridYip, C=24484249900en_HK
dc.identifier.scopusauthoridYuen, SF=14044250400en_HK
dc.identifier.scopusauthoridChim, S=6701728225en_HK
dc.identifier.scopusauthoridChan, WKY=55267670600en_HK
dc.identifier.scopusauthoridWong, SN=55267619000en_HK
dc.identifier.scopusauthoridHo, CS=36985962700en_HK
dc.identifier.scopusauthoridFeng, T=55268587600en_HK
dc.identifier.scopusauthoridLam, K=55267031100en_HK
dc.identifier.scopusauthoridLi, H=55267940000en_HK
dc.identifier.scopusauthoridLee, PPW=54782819300en_HK
dc.identifier.scopusauthoridMao, M=55268557300en_HK
dc.identifier.scopusauthoridLau, YL=7201403380en_HK

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