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Article: One-year follow up of melamine-associated renal stones in Sichuan and Hong Kong
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TitleOne-year follow up of melamine-associated renal stones in Sichuan and Hong Kong
 
AuthorsTu, WW3 4 2
Yang, H3
Luo, H3
Shi, H3
Wong, WHS4
Lau, WWS4
Yip, C8
Yuen, SF7
Chim, S4
Chan, WKY6
Wong, SN5
Ho, CS1
Feng, T2 3
Lam, K4
Li, H2 3
Lee, PPW4
Mao, M3
Lau, YL4
 
KeywordsCytokines
Interleukin-8
Melamine
Milk
Renal stones
 
Issue Date2012
 
PublisherMedcom Limited. The Journal's web site is located at http://www.hkjpaed.org/index.asp
 
CitationHong Kong Journal Of Paediatrics, 2012, v. 17 n. 1, p. 12-23 [How to Cite?]
 
AbstractBackground: An outbreak of melamine-associated renal stones occurred in mainland China in 2008, which led to large scale community screening of renal stones in Hong Kong. We hypothesised Hong Kong children screened positive did not suffer from melamine-associated renal stones. Methods: This one-year follow-up study compared the clinical features, renal ultrasound findings, and urinary interleukin 8 (IL-8) and monocyte chemoattractant protein 1 (MCP-1) to urinary creatinine ratios between 44 Sichuan children admitted to hospital for melamine-associated renal stones and 22 Hong Kong children screened positive with renal stones. Results: The mean age (±SD) in months of the Sichuan children (25.7±23.8) was significantly lower than that of Hong Kong children (75.0±42.1, p<0.0001). The melamine concentration in the milk consumed by the Sichuan children was significantly higher than that by Hong Kong children. All 44 Sichuan children and only 15 of the 22 Hong Kong children consumed melaminetainted milk product (MTMP). All except one of the 15 Hong Kong children had their daily melamineintake below the WHO tolerable daily intake of 0.2 mg melamine/Kg body weight. At diagnosis, the median number of stones and the mean largest stone size in the Sichuan children (4, 6.3 mm) were significantly higher than that in Hong Kong children (1, 3.8 mm, p<0.01). By 12 months follow-up, 28% and 48% of the Sichuan and Hong Kong children still had renal stones respectively. Urinary IL-8/creatinine ratio was significantly higher in Sichuan children with stones than other groups at 6 and 9 months followup. By 12 months follow-up, no such difference was observed among any groups. The above findings did not differ significantly whether the comparison with the Sichuan children was with the whole cohort of 22 Hong Kong children or the 15 who had consumed MTMP. In contrast, the 2 groups of Hong Kong children with and without MTMP consumption were similar in their demographics and clinical features. Conclusions: Hong Kong children had significantly different clinical features including MTMP consumption as compared to Sichuan children, suggesting Hong Kong children did not suffer from melamine-associated renal stones.
 
DescriptionFulltext link: http://www.hkjpaed.org/pdf/2012;17;12-23.pdf
 
ISSN1013-9923
2013 Impact Factor: 0.106
2013 SCImago Journal Rankings: 0.126
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorTu, WW
 
dc.contributor.authorYang, H
 
dc.contributor.authorLuo, H
 
dc.contributor.authorShi, H
 
dc.contributor.authorWong, WHS
 
dc.contributor.authorLau, WWS
 
dc.contributor.authorYip, C
 
dc.contributor.authorYuen, SF
 
dc.contributor.authorChim, S
 
dc.contributor.authorChan, WKY
 
dc.contributor.authorWong, SN
 
dc.contributor.authorHo, CS
 
dc.contributor.authorFeng, T
 
dc.contributor.authorLam, K
 
dc.contributor.authorLi, H
 
dc.contributor.authorLee, PPW
 
dc.contributor.authorMao, M
 
dc.contributor.authorLau, YL
 
dc.date.accessioned2012-07-16T09:48:36Z
 
dc.date.available2012-07-16T09:48:36Z
 
dc.date.issued2012
 
dc.description.abstractBackground: An outbreak of melamine-associated renal stones occurred in mainland China in 2008, which led to large scale community screening of renal stones in Hong Kong. We hypothesised Hong Kong children screened positive did not suffer from melamine-associated renal stones. Methods: This one-year follow-up study compared the clinical features, renal ultrasound findings, and urinary interleukin 8 (IL-8) and monocyte chemoattractant protein 1 (MCP-1) to urinary creatinine ratios between 44 Sichuan children admitted to hospital for melamine-associated renal stones and 22 Hong Kong children screened positive with renal stones. Results: The mean age (±SD) in months of the Sichuan children (25.7±23.8) was significantly lower than that of Hong Kong children (75.0±42.1, p<0.0001). The melamine concentration in the milk consumed by the Sichuan children was significantly higher than that by Hong Kong children. All 44 Sichuan children and only 15 of the 22 Hong Kong children consumed melaminetainted milk product (MTMP). All except one of the 15 Hong Kong children had their daily melamineintake below the WHO tolerable daily intake of 0.2 mg melamine/Kg body weight. At diagnosis, the median number of stones and the mean largest stone size in the Sichuan children (4, 6.3 mm) were significantly higher than that in Hong Kong children (1, 3.8 mm, p<0.01). By 12 months follow-up, 28% and 48% of the Sichuan and Hong Kong children still had renal stones respectively. Urinary IL-8/creatinine ratio was significantly higher in Sichuan children with stones than other groups at 6 and 9 months followup. By 12 months follow-up, no such difference was observed among any groups. The above findings did not differ significantly whether the comparison with the Sichuan children was with the whole cohort of 22 Hong Kong children or the 15 who had consumed MTMP. In contrast, the 2 groups of Hong Kong children with and without MTMP consumption were similar in their demographics and clinical features. Conclusions: Hong Kong children had significantly different clinical features including MTMP consumption as compared to Sichuan children, suggesting Hong Kong children did not suffer from melamine-associated renal stones.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.descriptionFulltext link: http://www.hkjpaed.org/pdf/2012;17;12-23.pdf
 
dc.identifier.citationHong Kong Journal Of Paediatrics, 2012, v. 17 n. 1, p. 12-23 [How to Cite?]
 
dc.identifier.epage23
 
dc.identifier.hkuros200724
 
dc.identifier.hkuros225554
 
dc.identifier.issn1013-9923
2013 Impact Factor: 0.106
2013 SCImago Journal Rankings: 0.126
 
dc.identifier.issue1
 
dc.identifier.scopuseid_2-s2.0-84863064236
 
dc.identifier.spage12
 
dc.identifier.urihttp://hdl.handle.net/10722/152791
 
dc.identifier.volume17
 
dc.languageeng
 
dc.publisherMedcom Limited. The Journal's web site is located at http://www.hkjpaed.org/index.asp
 
dc.publisher.placeHong Kong
 
dc.relation.ispartofHong Kong Journal of Paediatrics
 
dc.relation.referencesReferences in Scopus
 
dc.subjectCytokines
 
dc.subjectInterleukin-8
 
dc.subjectMelamine
 
dc.subjectMilk
 
dc.subjectRenal stones
 
dc.titleOne-year follow up of melamine-associated renal stones in Sichuan and Hong Kong
 
dc.typeArticle
 
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<description.abstract>Background: An outbreak of melamine-associated renal stones occurred in mainland China in 2008, which led to large scale community screening of renal stones in Hong Kong. We hypothesised Hong Kong children screened positive did not suffer from melamine-associated renal stones. Methods: This one-year follow-up study compared the clinical features, renal ultrasound findings, and urinary interleukin 8 (IL-8) and monocyte chemoattractant protein 1 (MCP-1) to urinary creatinine ratios between 44 Sichuan children admitted to hospital for melamine-associated renal stones and 22 Hong Kong children screened positive with renal stones. Results: The mean age (&#177;SD) in months of the Sichuan children (25.7&#177;23.8) was significantly lower than that of Hong Kong children (75.0&#177;42.1, p&lt;0.0001). The melamine concentration in the milk consumed by the Sichuan children was significantly higher than that by Hong Kong children. All 44 Sichuan children and only 15 of the 22 Hong Kong children consumed melaminetainted milk product (MTMP). All except one of the 15 Hong Kong children had their daily melamineintake below the WHO tolerable daily intake of 0.2 mg melamine/Kg body weight. At diagnosis, the median number of stones and the mean largest stone size in the Sichuan children (4, 6.3 mm) were significantly higher than that in Hong Kong children (1, 3.8 mm, p&lt;0.01). By 12 months follow-up, 28% and 48% of the Sichuan and Hong Kong children still had renal stones respectively. Urinary IL-8/creatinine ratio was significantly higher in Sichuan children with stones than other groups at 6 and 9 months followup. By 12 months follow-up, no such difference was observed among any groups. The above findings did not differ significantly whether the comparison with the Sichuan children was with the whole cohort of 22 Hong Kong children or the 15 who had consumed MTMP. In contrast, the 2 groups of Hong Kong children with and without MTMP consumption were similar in their demographics and clinical features. Conclusions: Hong Kong children had significantly different clinical features including MTMP consumption as compared to Sichuan children, suggesting Hong Kong children did not suffer from melamine-associated renal stones.</description.abstract>
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Author Affiliations
  1. Kwong Wah Hospital
  2. The University of Hong Kong Li Ka Shing Faculty of Medicine
  3. West China Hospital
  4. The University of Hong Kong
  5. Tuen Mun Hospital
  6. Queen Elizabeth Hospital Hong Kong
  7. Pamela Youde Nethersole Eastern Hospital
  8. United Christian Hospital Hong Kong